Physiological and methodological aspects of rate of force development assessment in human skeletal muscle

2017 ◽  
Vol 38 (5) ◽  
pp. 743-762 ◽  
Author(s):  
David Rodríguez-Rosell ◽  
Fernando Pareja-Blanco ◽  
Per Aagaard ◽  
Juan José González-Badillo
1998 ◽  
Vol 260 (2) ◽  
pp. 218-222 ◽  
Author(s):  
M.Stig Djurhuus ◽  
Niels A.H. Klitgaard ◽  
Claus Tveskov ◽  
Klavs Madsen ◽  
Bernadette Guldager ◽  
...  

1991 ◽  
Vol 11 (1) ◽  
pp. 41-49 ◽  
Author(s):  
O. Eiken ◽  
C. J. Sundberg ◽  
M. Esbjörnsson ◽  
A. Nygren ◽  
L. Kaijser

Biomechanisms ◽  
2008 ◽  
Vol 19 (0) ◽  
pp. 11-22
Author(s):  
Toshiaki ODA ◽  
Ryutaro HIMENO ◽  
Hiroaki KANEHISA ◽  
Tetsuo FUKUNAGA ◽  
Yasuo KAWAKAMI

2016 ◽  
Vol 310 (3) ◽  
pp. G163-G170 ◽  
Author(s):  
John McDaniel ◽  
Gangarao Davuluri ◽  
Elizabeth Ann Hill ◽  
Michelle Moyer ◽  
Ashok Runkana ◽  
...  

The mechanism of the nearly universal decreased muscle strength in cirrhosis is not known. We evaluated whether hyperammonemia in cirrhosis causes contractile dysfunction independent of reduced skeletal muscle mass. Maximum grip strength and muscle fatigue response were determined in cirrhotic patients and controls. Blood and muscle ammonia concentrations and grip strength normalized to lean body mass were measured in the portacaval anastomosis (PCA) and sham-operated pair-fed control rats ( n = 5 each). Ex vivo contractile studies in the soleus muscle from a separate group of Sprague-Dawley rats ( n = 7) were performed. Skeletal muscle force of contraction, rate of force development, and rate of relaxation were measured. Muscles were also subjected to a series of pulse trains at a range of stimulation frequencies from 20 to 110 Hz. Cirrhotic patients had lower maximum grip strength and greater muscle fatigue than control subjects. PCA rats had a 52.7 ± 13% lower normalized grip strength compared with control rats, and grip strength correlated with the blood and muscle ammonia concentrations ( r2 = 0.82). In ex vivo muscle preparations following a single pulse, the maximal force, rate of force development, and rate of relaxation were 12.1 ± 3.5 g vs. 6.2 ± 2.1 g; 398.2 ± 100.4 g/s vs. 163.8 ± 97.4 g/s; −101.2 ± 22.2 g/s vs. −33.6 ± 22.3 g/s in ammonia-treated compared with control muscle preparation, respectively ( P < 0.001 for all comparisons). Tetanic force, rate of force development, and rate of relaxation were depressed across a range of stimulation from 20 to 110 Hz. These data provide the first direct evidence that hyperammonemia impairs skeletal muscle strength and increased muscle fatigue and identifies a potential therapeutic target in cirrhotic patients.


2018 ◽  
Author(s):  
S Höckele ◽  
P Huypens ◽  
C Hoffmann ◽  
T Jeske ◽  
M Hastreiter ◽  
...  

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 159-OR
Author(s):  
THEODORE P. CIARALDI ◽  
SUNDER MUDALIAR ◽  
LIWU LI ◽  
ROSARIO SCALIA ◽  
XIAO JIAN SUN ◽  
...  

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1891-P
Author(s):  
THERESIA SARABHAI ◽  
CHRYSI KOLIAKI ◽  
SABINE KAHL ◽  
DOMINIK PESTA ◽  
LUCIA MASTROTOTARO ◽  
...  

Diabetes ◽  
1997 ◽  
Vol 46 (12) ◽  
pp. 1965-1969 ◽  
Author(s):  
S. Lund ◽  
G. D. Holman ◽  
J. R. Zierath ◽  
J. Rincon ◽  
L. A. Nolte ◽  
...  

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