New insight of functional molecular imaging into the atheroma biology: 18F-NaF and 18F-FDG in symptomatic and asymptomatic carotid plaques after recent CVA. Preliminary results

2015 ◽  
Vol 36 (6) ◽  
pp. 499-503 ◽  
Author(s):  
R. Quirce ◽  
I. Martínez-Rodríguez ◽  
I. Banzo ◽  
J. Jiménez-Bonilla ◽  
N. Martínez-Amador ◽  
...  
Diagnostics ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1355
Author(s):  
Adrien Holzgreve ◽  
Matthias P. Fabritius ◽  
Thomas Knösel ◽  
Lena M. Mittlmeier ◽  
Johannes Rübenthaler ◽  
...  

Benign so-called “brown tumors” secondary to hyperparathyroidism are a rare diagnostic pitfall due to their impressively malignant-like character in various imaging modalities. We present the case of a 65-year-old male patient with multiple unclear osteolytic lesions on prior imaging suspicious for metastatic malignant disease. Eventually, findings of 18F-FDG PET/CT staging and 99mTc-MIBI scintigraphy resulted in revision of the initially suspected malignant diagnosis. This case illustrates how molecular imaging findings non-invasively corroborate the correct diagnosis of osteitis fibrosa cystica generalisata with the formation of multiple benign brown tumors.


2013 ◽  
Vol 13 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Simone Maurea ◽  
Giovanni Fiumara ◽  
Teresa Pellegrino ◽  
Emilia Zampella ◽  
Roberta Assante ◽  
...  

1993 ◽  
Vol 80 (10) ◽  
pp. 1274-1277 ◽  
Author(s):  
G. Geroulakos ◽  
G. Ramaswami ◽  
A. Nicolaides ◽  
K. James ◽  
N. Labropoulos ◽  
...  

2008 ◽  
Vol 35 (7) ◽  
pp. 1316-1322 ◽  
Author(s):  
Laura L. Travaini ◽  
Giuseppe Trifirò ◽  
Laura Ravasi ◽  
Lorenzo Monfardini ◽  
Paolo Della Vigna ◽  
...  

Vascular ◽  
2021 ◽  
pp. 170853812110609
Author(s):  
Guyue Liu ◽  
Qing Xu ◽  
Min Sun ◽  
Rong Xiao

Aims Hypertension is a major risk factor for coronary, cerebrovascular, and the greatest cause of stroke. Half of stroke events are the result of cerebrovascular atherosclerosis, including carotid plaques. It is of major importance to detect which plaques are vulnerable, even though not yet ruptured. Due to the particularity of the Tibetan population, this study evaluated the elasticity of asymptomatic carotid plaques in Tibetan hypertension patients using shear wave elastography (SWE) and explored associated risk factors. Methods A total of 91 Tibetan patients were divided into normotension, grade 1-2, and grade 3 hypertension groups based on the level of blood pressure. All subjects underwent common duplex ultrasonic examination and SWE evaluation for carotid plaques. Elasticity of carotid plaque was assessed by Young’s modulus. Results The final analysis included 126 plaques as representative plaques according to Total Plaque Risk Score. The mean and maximum Young’s modulus in the grade 3 hypertension group were smaller, and more plaques with irregularity surface compared with the other two groups ( p < 0.05). Multivariate regression analysis showed drinking butter tea (β = −0.220, p = 0.009; β = −0.240, p = 0.004, respectively) was the independent factor associated with mean and maximum Young’s modulus. Conclusions SWE is feasible for measurement of Young’s modulus of carotid plaques. Plaques in the grade 3 hypertension group were more likely to become vulnerable ones. In hypertension Tibetan patients, drinking butter tea was an independent factor associated with mean and maximum Young’s modulus of asymptomatic carotid plaque.


2013 ◽  
Vol 57 (3) ◽  
pp. 609-618.e1 ◽  
Author(s):  
Stavros K. Kakkos ◽  
Maura B. Griffin ◽  
Andrew N. Nicolaides ◽  
Efthyvoulos Kyriacou ◽  
Michael M. Sabetai ◽  
...  

2006 ◽  
Vol 19 (1) ◽  
pp. 205873920601900 ◽  
Author(s):  
R. Sessa ◽  
M. DI Pietro ◽  
G. Schiavoni ◽  
M. Galdiero ◽  
P. Cipriani ◽  
...  

We evaluated, in 415 patients with asymptomatic carotid atherosclerosis: (i) the prevalence of C. pneumoniae DNA in atherosclerotic carotid plaques and peripheral blood mononuclear cells (PBMC); (ii) the distribution of C. pneumoniae in atherosclerotic carotid plaques and PBMC from the same patients; (iii) the correlation between circulating anti-chlamydial antibodies and the presence of C. pneumoniae DNA. Overall, 160 atherosclerotic carotid plaques and 174 PBMC specimens from patients with asymptomatic carotid atherosclerosis were examined by ompA nested touchdown PCR for presence of C. pneumoniae. In addition, C. pneumoniae DNA was detected in 81 specimens of atherosclerotic carotid plaque and PBMC obtained from the same patients. C. pneumoniae DNA was found in 36.9% of atherosclerotic carotid plaques and in 40.2% of PBMC specimens examined (P=NS). With regard to 81 patients, C. pneumoniae DNA was detected in 27.2% of atherosclerotic carotid plaques and in 44.4% of PBMC specimens (P=0.05). In 18 patients, the presence of C. pneumoniae DNA in PBMC specimens and atherosclerotic carotid plaques coincided (P=0.005). No statistically significant association was found between anti-C pneumoniae antibodies (IgG and IgA) and positive PCR results. In conclusion, our results suggest that the detection of C. pneumoniae DNA in PBMC specimens seems to be a first-choice method to identify the patients at risk for endovascular chlamydial infection.


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