Conventional treatment after myocardial infarction in routine clinical practice results in regression of left common carotid intima-media thickness

2013 ◽  
Vol 34 (4) ◽  
pp. 322-326
Author(s):  
Tomas Jogestrand ◽  
Stefan Agewall ◽  
Thomas Gustafsson ◽  
Loghman Henareh
Keyword(s):  
Myocardial Infarction ◽  
Clinical Practice ◽  
Conventional Treatment ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Routine Clinical Practice ◽  
Media Thickness

scholarly journals Sitagliptin on Carotid Intima-Media Thickness in Type 2 Diabetes Mellitus Patients and Anemia: A Subgroup Analysis of the PROLOGUE Study

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Zhengri Lu ◽  
Genshan Ma ◽  
Lijuan Chen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Treatment Group ◽  
Conventional Treatment ◽  
Randomized Clinical Trials ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

Introduction. Randomized clinical trials have not shown an additional clinical benefit of sitagliptin treatment over conventional treatment alone. However, studies of sitagliptin treatment have not examined the relationship between anemia and treatment group outcomes. Methods. The PROLOGUE study is a prospective clinical trial of 442 participants with type 2 diabetes mellitus (T2DM) randomized to sitagliptin treatment or conventional treatment which showed no treatment differences [Estimated mean (± standard error) common carotid intima-media thickness (CIMT) was 0.827±0.007 mm and 0.837±0.007 mm, respectively, with a mean difference of -0.009 mm (97.2% CI −0.028 to 0.011, p=0.309) at 24 mo of follow-up]. This is a post hoc subanalysis using data obtained from the PROLOGUE study; the study population was divided into anemic groups (n=94) and nonanemic group (n=343) based on hemoglobin level. And we analyzed for the changes in each CIMT parameter from baseline to 24 months in subgroups. Results. The treatment group difference in baseline-adjusted mean common carotid artery- (CCA-) IMT at 24 months was −0.003 mm (95% CI −0.022 to 0.015, p=0.718) in the nonanemic subgroup and −0.007 mm (95% CI −0.043 to 0.030, p=0.724) in the anemic subgroup. Although there were no significant differences in the other CIMT parameters between the treatment groups in the anemic subgroup, the changes in mean and max ICA-IMT at 24 months in the nonanemic subgroup were significantly lower in the sitagliptin group than the conventional group [−0.104 mm (95% CI −0.182 to −0.026), p=0.009 and −0.142 mm (−0.252 to −0.033), p=0.011, respectively]. Conclusion. These data suggest that nonanemia may indicate a potentially large subgroup of those with T2DM patients that sitagliptin therapy has a better antiatherosclerotic effect than conventional therapy. Further research is needed to confirm these preliminary observations.

scholarly journals Common Carotid Intima-Media Thickness and Risk of Acute Myocardial Infarction

Stroke ◽  
2005 ◽  
Vol 36 (4) ◽  
pp. 762-767 ◽  
Author(s):  
Michiel L. Bots ◽  
Diederick E. Grobbee ◽  
Albert Hofman ◽  
Jacqueline C.M. Witteman
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals The Relationship Between Aspirin Resistance and Carotid Imaging in Young Patients With ST-Segment Elevated Myocardial Infarction: A Cross-Sectional Study

2018 ◽  
Vol 24 (8) ◽  
pp. 1358-1364
Author(s):  
Mustafa Umut Somuncu ◽  
Ali Riza Demir ◽  
Huseyin Karakurt ◽  
Nail Guven Serbest ◽  
Belma Kalayci ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
High Risk ◽  
Carotid Plaque ◽  
Young Patients ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Aspirin Resistance ◽  
Cross Sectional ◽  
Media Thickness ◽  
St Segment

The presence of carotid atherosclerosis accompanied by coronary artery disease is associated with poor prognosis. A subset of patients who take aspirin continue to have recurrent cardiovascular events, which may be due to aspirin resistance (AR). Also, carotid plaques may cause turbulent flow which in turn may lead to platelet activation and poor antiplatelet response. In our study, we aimed to show the prevalence of AR and its relationship between high-risk carotid images in young patients with ST-segment elevated myocardial infarction (STEMI). In our study, we included 112 patients younger than 45 years with STEMI. Aspirin response test was evaluated 1 hour after aspirin intake using multiplate platelet function analyzer, and carotid ultrasonography has been performed to determine carotid intima–media thickness (CIMT) and the presence of carotid plaque. We identified 30.3% AR in young patients with STEMI. Carotid intima–media thickness ( P = .002), carotid plaque ( P = .012), and high-risk carotid image ( P = .015) values are significantly high in patients who have AR. Independent of other risk factors, the presence of carotid plaque and being in the high-risk carotid group were associated with 3.7 times and 3.2 times increased odds for AR, respectively. In young patients with STEMI, physicians should be careful about AR, especially in patients who have carotid plaque and thicker CIMT.

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