Extended versus segmental colectomy for mid‐transverse colon cancers: an unsolved question

2021 ◽  
Author(s):  
Maurizio Zizzo ◽  
Magda Zanelli ◽  
Francesca Sanguedolce ◽  
Carolina Castro Ruiz ◽  
Andrea Morini ◽  
...  
Keyword(s):  
Transverse Colon ◽  
Colon Cancers ◽  
Segmental Colectomy

Dedifferentiated Liposarcoma of the Transverse Colon

2021 ◽  
pp. 000313482110545
Author(s):  
Katie Fitzgerald ◽  
Eliza M. Slama ◽  
Irina Bernescu
Keyword(s):  
Transverse Colon ◽  
Soft Tissue Sarcomas ◽  
Surgical Excision ◽  
Dedifferentiated Liposarcoma ◽  
High Grade ◽  
Nodal Involvement ◽  
Segmental Colectomy ◽  
Aggressive Tumor ◽  
Disease Free

While liposarcoma is one of the most common soft tissue sarcomas, it is rarely seen within the gastrointestinal tract, and even less frequently seen within the colon. Dedifferentiated liposarcoma is a subtype of liposarcoma, which along with the pleomorphic subtype is considered a high-grade, aggressive tumor; both possess the ability to metastasize and are associated with decreased survival. Despite complete resection, recurrence is common. While surgical excision is the cornerstone of treatment for liposarcoma of the colon, there is no consensus on adjuvant therapies. We present the case of a 66-year-old woman who presented with abdominal pain with rectal bleeding and was found on colonoscopy to have a high-grade dedifferentiated liposarcoma of the transverse colon. She underwent robotic segmental colectomy. Due to absence of nodal involvement or distal metastasis, adjuvant therapy was not administered. On 1-year follow-up, the patient remains disease free.

Are transverse colon cancers suitable for laparoscopic resection?

2006 ◽  
Vol 21 (3) ◽  
pp. 396-399 ◽  
Author(s):  
Christopher M. Schlachta ◽  
Joseph Mamazza ◽  
Eric C. Poulin
Keyword(s):  
Transverse Colon ◽  
Laparoscopic Resection ◽  
Colon Cancers

Prognostic Factors for Survival in Transverse Colon Cancers

2021 ◽  
Author(s):  
Ahmet Küçükarda ◽  
Ali Gökyer ◽  
Sezin Sayın ◽  
İvo Gökmen ◽  
Erkan Özcan ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Transverse Colon ◽  
Colon Cancers

scholarly journals Unexplained anemia: A case report of metachronous adenocarcinoma arising in the transverse colon following right hemicolectomy for a primary cecal carcinoma

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Asim Malik ◽  
Asad Ur-Rahman ◽  
Syed Muhammad Hammad Ali
Keyword(s):  
Colorectal Cancer ◽  
Gastrointestinal Bleeding ◽  
Transverse Colon ◽  
Right Hemicolectomy ◽  
Field Cancerization ◽  
Primary Adenocarcinoma ◽  
Second Primary ◽  
Primary Colorectal Cancer ◽  
Colon Cancers ◽  
Colorectal Cancer Resection

Metachronous colonic carcinomas arise from months to years after the resection of the first or index primary colorectal cancer. They are not a result of tumor recurrence or metastasis and likely arise as a result of the field cancerization effect. This report presents the case of a 63-year-old male patient without family history of a colorectal cancer but had an index primary adenocarcinoma of the cecum (stage IIIC) five years ago that was treated with surgical resection and adjuvant radiotherapy and chemotherapy. He presented with fatigue and anemia of 6-month duration secondary to recurrent melena, and the specific cause of which remained obscure despite intensive diagnostic workup. Recurrence of a malignancy at the previous anastomosis site was ruled out. The patient continued to have recurrent and intermittent gastrointestinal bleeding until a nuclear red blood cell scan detected a bleeding spot in the epigastric region, which actually turned out to be a second primary carcinoma (stage I) arising from an adenoma in the transverse colon. The patient underwent a left colectomy with ileosigmoid anastomosis formation. During a two-month postoperative follow-up, the patient did not experience any episode of melena or anemia. Even though metachronous colon cancers rarely present with a recurrent and intermittent gastrointestinal bleeding with melena, an aggressive workup must be aimed at ruling out a second independent malignancy in patients who are in remission after an index primary colorectal cancer resection through hemicolectomy. Any neoteric lesion found on colonoscopy in such cases should be dealt with a higher degree of suspicion. Therefore, the need for surveillance colonoscopy as recommended by the National Comprehensive Cancer Network guidelines is imperative and should be practiced in resource-limited countries.

scholarly journals Benefit from anti-EGFRs in RAS and BRAF wild-type metastatic transverse colon cancer: a clinical and molecular proof of concept study

ESMO Open ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. e000489 ◽  
Author(s):  
Chiara Cremolini ◽  
Matteo Benelli ◽  
Elisa Fontana ◽  
Filippo Pagani ◽  
Daniele Rossini ◽  
...  
Keyword(s):  
Transverse Colon ◽  
Cancer Biology ◽  
Primary Tumour ◽  
Growth Factor Receptor ◽  
Progression Free Survival ◽  
Disease Stabilisation ◽  
Transverse Colon Cancer ◽  
Wild Type ◽  
Colon Cancers ◽  
Tcga Dataset

ObjectivePrimary tumour location is regarded as a reliable surrogate of colorectal cancer biology. Sensitivity to anti-EGFRs (Epidermal Growth Factor Receptor) of metastatic transverse colon cancers (mTCCs) has usually been assumed similar to right-sided tumours; however, evidence about the clinical behaviour of mTCC is limited. Thus, to verify sensitivity of mTCC to anti-EGFRs we conducted the present study.MethodsPatients with RAS/BRAF wild-type microsatellite stable (MSS) mTCC receiving anti-EGFR monotherapy, or in combination with irinotecan if clearly irinotecan-refractory, were included. Hypothesising an overall response rate (ORR) of 35%, 11 patients, of whom at least 3 were responders, were necessary to be able to reject the null hypothesis of an ORR of 5%, with α and β errors of 0.05 and 0.20. PRESSING panel and consensus molecular subtypes (CMS) were assessed on tumour samples, whereas in-silico data were obtained from TCGA dataset.ResultsAmong nine eligible patients, four and three achieved response and disease stabilisation (ORR 44%). At a median follow-up of 23.1 months, median progression-free survival and overall survival were 7.3 (95% CI 3.9 to NA) and 15.0 months (95% CI 10.0 to NA), respectively. A MET amplification and an ERBB4 S303F substitution were detected in patients with rapid disease progression, while others had PRESSING panel-negative tumours with CMS2 or CMS4 subtypes.ConclusionsRAS/BRAF wild-type MSS mTCCs may be sensitive to anti-EGFRs, as confirmed by molecular analyses.

scholarly journals Segmental resection of splenic flexure colon cancers provides an adequate lymph node harvest and is a safe operative approach – an analysis of the ACS-NSQIP database

2022 ◽  
Author(s):  
Allison J. Pang ◽  
Daniel Marinescu ◽  
Nancy Morin ◽  
Carol-Ann Vasilevsky ◽  
Marylise Boutros
Keyword(s):  
Lymph Node ◽  
Splenic Flexure ◽  
Operative Time ◽  
Segmental Resection ◽  
Operative Morbidity ◽  
Left Hemicolectomy ◽  
Lymph Node Harvest ◽  
Colon Cancers ◽  
Segmental Colectomy ◽  
Splenic Flexure Cancer

Abstract Introduction Fewer than 10% of colon cancers are found at the splenic flexure. A standard surgical approach to these cancers has not been defined. The goal of this study was to compare lymph node harvest and post-operative morbidity between segmental resection and formal left hemicolectomy for splenic flexure colon cancers. Method Patients diagnosed with a splenic flexure cancer were identified from the 2012–2018 ACS-NSQIP colectomy-targeted database. Patients were categorized based on type of surgical resection – left hemicolectomy with colorectal anastomosis or segmental colectomy with colocolonic anastomosis. Demographic, clinicopathologic, and post-operative outcomes were compared between groups. Factors independently associated with lymph node harvest, operative time, and post-operative morbidity were investigated by linear and binomial logistic regression models. Results A total of 3,049 patients underwent colectomy for a splenic flexure cancer. Of these, 83.6% had a segmental colectomy and 73% were performed by a minimally invasive approach. T- and N-stage did not differ between segmental and left hemicolectomy groups (p = 0.703 and p = 0.429, respectively). Inadequate nodal harvest (< 12 nodes) was infrequent and similar between the two procedures (7.4% vs. 9.1%, p = 0.13). Operative time was significantly shorter for segmental colectomy (213 ± 83.5 min vs. 193 ± 84.1 min, p < 0.0001) and major morbidity was similar between the two surgical techniques (8.4% vs. 8.9%, p = 0.75). After accounting for demographic, clinicopathologic, and operative factors, binomial logistic regression showed that type of procedure was not significantly associated with LN harvest (OR 0.80, 95%CI 0.54–1.17) or major morbidity (OR 1.17, 95%CI 0.36–3.81). However, on linear regression, segmental splenic flexure resection was associated with shorter operative time (estimate 20.29, 95%CI 12.61–27.97, p < 0.0001). Conclusion Splenic flexure resection for colon cancer is associated with an adequate lymph node harvest. Compared to a formal left hemicolectomy, a segmental resection also has a shorter operative time with equivalent post-operative morbidity.

Tuberculosis of the Transverse Colon

1959 ◽  
Vol 36 (5) ◽  
pp. 698-701 ◽  
Author(s):  
Allan R. Aronson ◽  
Louis R. Slattery
Keyword(s):  
Transverse Colon
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