scholarly journals Early detection and follow‐up of colorectal neoplasia based on faecal volatile organic compounds

2020 ◽  
Vol 22 (9) ◽  
pp. 1119-1129 ◽  
Author(s):  
S. Bosch ◽  
R. Bot ◽  
A. Wicaksono ◽  
E. Savelkoul ◽  
R. Hulst ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Early Detection ◽  
Organic Compounds ◽  
Colorectal Neoplasia ◽  
Volatile Organic

scholarly journals Breath Analysis for Early Detection of Malignant Pleural Mesothelioma: Volatile Organic Compounds (VOCs) Determination and Possible Biochemical Pathways

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1262 ◽  
Author(s):  
Alessia Di Gilio ◽  
Annamaria Catino ◽  
Angela Lombardi ◽  
Jolanda Palmisani ◽  
Laura Facchini ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Early Detection ◽  
Organic Compounds ◽  
Malignant Pleural Mesothelioma ◽  
Breath Analysis ◽  
Machine Learning Algorithms ◽  
Diagnostic Methods ◽  
Pleural Mesothelioma ◽  
Healthy Controls ◽  
Volatile Organic

Malignant pleural mesothelioma (MPM) is a rare neoplasm, mainly caused by asbestos exposure, with a high mortality rate. The management of patients with MPM is controversial due to a long latency period between exposure and diagnosis and because of non-specific symptoms generally appearing at advanced stage of the disease. Breath analysis, aimed at the identification of diagnostic Volatile Organic Compounds (VOCs) pattern in exhaled breath, is believed to improve early detection of MPM. Therefore, in this study, breath samples from 14 MPM patients and 20 healthy controls (HC) were collected and analyzed by Thermal Desorption-Gas Chromatography-Mass Spectrometry (TD-GC/MS). Nonparametric test allowed to identify the most weighting variables to discriminate between MPM and HC breath samples and multivariate statistics were applied. Considering that MPM is an aggressive neoplasm leading to a late diagnosis and thus the recruitment of patients is very difficult, a promising data mining approach was developed and validated in order to discriminate between MPM patients and healthy controls, even if no large population data are available. Three different machine learning algorithms were applied to perform the classification task with a leave-one-out cross-validation approach, leading to remarkable results (Area Under Curve AUC = 93%). Ten VOCs, such as ketones, alkanes and methylate derivates, as well as hydrocarbons, were able to discriminate between MPM patients and healthy controls and for each compound which resulted diagnostic for MPM, the metabolic pathway was studied in order to identify the link between VOC and the neoplasm. Moreover, five breath samples from asymptomatic asbestos-exposed persons (AEx) were exploratively analyzed, processed and tested by the validated statistical method as blinded samples in order to evaluate the performance for the early recognition of patients affected by MPM among asbestos-exposed persons. Good agreement was found between the information obtained by gold-standard diagnostic methods such as computed tomography CT and model output.

Early Detection of Necrotizing Enterocolitis by Fecal Volatile Organic Compounds Analysis

2015 ◽  
Vol 167 (3) ◽  
pp. 562-567.e1 ◽  
Author(s):  
Tim G.J. de Meij ◽  
Marc P.C. van der Schee ◽  
Daan J.C. Berkhout ◽  
Mirjam E. van de Velde ◽  
Anna E. Jansen ◽  
...  
Keyword(s):  
Volatile Organic Compounds ◽  
Early Detection ◽  
Organic Compounds ◽  
Necrotizing Enterocolitis ◽  
Volatile Organic

Effects of Curative Colorectal Cancer Surgery on Exhaled Volatile Organic Compounds and Potential Implications in Clinical Follow-up

2015 ◽  
Vol 262 (5) ◽  
pp. 862-867 ◽  
Author(s):  
Donato F. Altomare ◽  
Maria Di Lena ◽  
Francesca Porcelli ◽  
Elisabetta Travaglio ◽  
Francesco Longobardi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Volatile Organic

scholarly journals Advances in the Early Detection of Lung Cancer using Analysis of Volatile Organic Compounds: From Imaging to Sensors

2014 ◽  
Vol 15 (11) ◽  
pp. 4377-4384 ◽  
Author(s):  
Wang Li ◽  
Hong-Ying Liu ◽  
Zi-Ru Jia ◽  
Pan-Pan Qiao ◽  
Xi-Tian Pi ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Volatile Organic Compounds ◽  
Early Detection ◽  
Organic Compounds ◽  
Volatile Organic

scholarly journals A Synergism Between Dimethyl Trisulfide And Methyl Thiolacetate In Attracting Carrion-Frequenting Beetles Demonstrated By Use Of A Chemically-Supplemented Minimal Trap

2020 ◽  
Author(s):  
Stephen T. Trumbo ◽  
John A. Dicapua
Keyword(s):  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Community Assembly ◽  
Ecological Succession ◽  
Dimethyl Trisulfide ◽  
Complex Component ◽  
Volatile Organic ◽  
Final Approach ◽  
Volatile Cues

AbstractMicrobially-derived volatile organic compounds recruit insects to carrion, shaping community assembly and ecological succession. The importance of individual volatiles and interactions between volatiles are difficult to assess in the field because of (1) the myriad compounds from decomposing animals, and (2) the likelihood that complex component blends are important for the final approach to carrion. On the assumption that searching insects may use simpler volatile cues to orient at a distance, we employed a chemically-supplemented minimal trap that uses test chemicals to attract from a distance and a minimal carrion bait to induce trap entry. Traps supplemented with dimethyl trisulfide (DMTS) attracted more individuals than controls, while traps supplemented only with methyl thiolacetate (MeSAc) did not. Traps supplemented with both chemicals, however, attracted statistically greater numbers of adult silphids (Necrophila americana and Oiceoptoma noveboracense), and the histerid Euspilotus assimilis than the combined totals of DMTS-only and MeSAc-only traps, demonstrating a synergism. The attraction of Necrophila americana larvae to traps left in the field for less than 24 h suggests that this species sometimes moves between carrion sources; a follow-up experiment in the laboratory demonstrated that larvae have the ability to feed on non-carrion insects and to survive without food while moving between carcasses. The use of such species for forensic applications requires caution.

Fecal volatile organic compounds for early detection of colorectal cancer: where are we now?

2018 ◽  
Vol 145 (1) ◽  
pp. 223-234 ◽  
Author(s):  
Sofie Bosch ◽  
Daniel J. Berkhout ◽  
Ilhame Ben Larbi ◽  
Tim G. de Meij ◽  
Nanne K. de Boer
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Early Detection ◽  
Organic Compounds ◽  
Volatile Organic
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