Does neoadjuvant therapy increase the incidence of anastomotic leakage after anterior resection for mid and low rectal cancer? A systematic review and meta-analysis

2017 ◽  
Vol 19 (1) ◽  
pp. 16-26 ◽  
Author(s):  
M.-H. Hu ◽  
R.-K. Huang ◽  
R.-S. Zhao ◽  
K.-L. Yang ◽  
H. Wang
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Neoadjuvant Therapy ◽  
Anastomotic Leakage ◽  
Anterior Resection ◽  
Meta Analysis ◽  
Low Rectal Cancer

scholarly journals Rise and fall of total mesorectal excision with lateral pelvic lymphadenectomy for rectal cancer: an updated systematic review and meta-analysis of 11,366 patients

2021 ◽  
Author(s):  
Gabriele Anania ◽  
Richard Justin Davies ◽  
Alberto Arezzo ◽  
Francesco Bagolini ◽  
Vito D’Andrea ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Total Mesorectal Excision ◽  
Neoadjuvant Therapy ◽  
Functional Outcomes ◽  
Meta Analysis ◽  
Neoadjuvant Chemoradiotherapy ◽  
Disease Free Survival ◽  
Mesorectal Excision ◽  
Timeline Analysis

Abstract The role of lateral lymph node dissection (LLND) during total mesorectal excision (TME) for rectal cancer is still controversial. Many reviews were published on prophylactic LLND in rectal cancer surgery, some biased by heterogeneity of overall associated treatments. The aim of this systematic review and meta-analysis is to perform a timeline analysis of different treatments associated to prophylactic LLND vs no-LLND during TME for rectal cancer. Methods A literature search was performed in PubMed, SCOPUS and WOS for publications up to 1 September 2020. We considered RCTs and CCTs comparing oncologic and functional outcomes of TME with or without LLND in patients with rectal cancer. Results Thirty-four included articles and 29 studies enrolled 11,606 patients. No difference in 5-year local recurrence (in every subgroup analysis including preoperative neoadjuvant chemoradiotherapy), 5-year distant and overall recurrence, 5-year overall survival and 5-year disease-free survival was found between LLND group and non LLND group. The analysis of post-operative functional outcomes reported hindered quality of life (urinary, evacuatory and sexual dysfunction) in LLND patients when compared to non LLND. Conclusion Our publication does not demonstrate that TME with LLND has any oncological advantage when compared to TME alone, showing that with the advent of neoadjuvant therapy, the advantage of LLND is lost. In this review, the most important bias is the heterogeneous characteristics of patients, cancer staging, different neoadjuvant therapy, different radiotherapy techniques and fractionation used in different studies. Higher rate of functional post-operative complications does not support routinely use of LLND.

Effect of Left Colonic Artery Preservation on Anastomotic Leakage in Laparoscopic Anterior Resection for Middle and Low Rectal Cancer

2013 ◽  
Vol 37 (12) ◽  
pp. 2935-2943 ◽  
Author(s):  
Takao Hinoi ◽  
Masazumi Okajima ◽  
Manabu Shimomura ◽  
Hiroyuki Egi ◽  
Hideki Ohdan ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Anastomotic Leakage ◽  
Anterior Resection ◽  
Low Rectal Cancer ◽  
Laparoscopic Anterior Resection

Endoscopic repair of anastomotic leakage after low anterior resection for rectal cancer: A systematic review

2020 ◽  
Vol 13 (2) ◽  
pp. 141-146
Author(s):  
Angeliki Chorti ◽  
George Stavrou ◽  
Veronica Stelmach ◽  
Georgia Tsaousi ◽  
Antonios Michalopoulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Rectal Cancer ◽  
Anastomotic Leakage ◽  
Anterior Resection ◽  
Low Anterior Resection ◽  
Endoscopic Repair
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