Volatile organic compounds as new biomarkers for colorectal cancer: a review

2016 ◽  
Vol 18 (7) ◽  
pp. 654-663 ◽  
Author(s):  
M. Di Lena ◽  
F. Porcelli ◽  
D. F. Altomare
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic ◽  
New Biomarkers

scholarly journals Are Volatile Organic Compounds Accurate Markers in the Assessment of Colorectal Cancer and Inflammatory Bowel Diseases? A Review

Cancers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 2361
Author(s):  
Filippo Vernia ◽  
Marco Valvano ◽  
Stefano Fabiani ◽  
Gianpiero Stefanelli ◽  
Salvatore Longo ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Inflammatory Bowel Diseases ◽  
Screening Programs ◽  
Inflammatory Status ◽  
Incidence And Mortality ◽  
Volatile Organic ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the Western world. Early detection decreases incidence and mortality. Screening programs based on fecal occult blood testing help identify patients requiring endoscopic examination, but accuracy is far from optimal. Among the alternative strategies, volatile organic compounds (VOCs) represent novel potentially useful biomarkers of colorectal cancer. They also represent a promising tool for the screening of both intestinal inflammation and related CRC. The review is focused on the diagnostic potential of VOCs in sporadic CRC and in inflammatory bowel diseases (IBD), which increase the risk of CRC, analyzing future clinical applications. Despite limitations related to inadequate strength of evidence, differing analytical platforms identify different VOCs, and this unconventional approach for diagnosing colorectal cancer is promising. Some VOC profiles, besides identifying inflammation, seem disease-specific in inflammatory bowel diseases. Thus, breath, urine, and fecal VOCs provide a new and promising clinical approach to differential diagnosis, evaluation of the inflammatory status, and possibly the assessment of treatment efficacy in IBD. Conversely, specific VOC patterns correlating inflammatory bowel disease and cancer risk are still lacking, and studies focused on this issue are strongly encouraged. No prospective studies have assessed the risk of CRC development by using VOCs in samples collected before the onset of disease, both in the general population and in patients with IBD.

scholarly journals Global Plasma Profiling for Colorectal Cancer-Associated Volatile Organic Compounds: a Proof-of-Principle Study

2019 ◽  
Vol 57 (5) ◽  
pp. 385-396 ◽  
Author(s):  
Seongho Kim ◽  
Xinmin Yin ◽  
Md Aminul Islam Prodhan ◽  
Xiang Zhang ◽  
Zichun Zhong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic ◽  
Proof Of Principle

Effects of Curative Colorectal Cancer Surgery on Exhaled Volatile Organic Compounds and Potential Implications in Clinical Follow-up

2015 ◽  
Vol 262 (5) ◽  
pp. 862-867 ◽  
Author(s):  
Donato F. Altomare ◽  
Maria Di Lena ◽  
Francesca Porcelli ◽  
Elisabetta Travaglio ◽  
Francesco Longobardi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Cancer Surgery ◽  
Colorectal Cancer Surgery ◽  
Volatile Organic

Urinary volatile organic compounds and faecal microbiome profiles in colorectal cancer

2019 ◽  
Vol 21 (11) ◽  
pp. 1259-1269 ◽  
Author(s):  
M. McFarlane ◽  
A. Millard ◽  
H. Hall ◽  
R. Savage ◽  
C. Constantinidou ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic ◽  
Faecal Microbiome

scholarly journals Exhaled volatile organic compounds identify patients with colorectal cancer

2012 ◽  
Vol 100 (1) ◽  
pp. 144-150 ◽  
Author(s):  
D. F. Altomare ◽  
M. Di Lena ◽  
F. Porcelli ◽  
L. Trizio ◽  
E. Travaglio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Volatile Organic Compounds ◽  
Organic Compounds ◽  
Volatile Organic
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