Airborne contact dermatitis apparently acquired as a result of using pericarp juice from an Indian marking nut as a home remedy to treat patchy hair loss

Ghanshyam Verma; G.R. Tegta; Ranu Rattan; Reena Sharma; Amar Singh

doi:10.1111/cod.13275

Airborne contact dermatitis apparently acquired as a result of using pericarp juice from an Indian marking nut as a home remedy to treat patchy hair loss

Contact Dermatitis ◽

10.1111/cod.13275 ◽

2019 ◽

Vol 81 (3) ◽

pp. 211-213

Author(s):

Ghanshyam Verma ◽

G.R. Tegta ◽

Ranu Rattan ◽

Reena Sharma ◽

Amar Singh

Keyword(s):

Contact Dermatitis ◽

Hair Loss ◽

Home Remedy

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Risks of work with cytotoxic drugs

Infusion & Chemotherapy ◽

10.32902/2663-0338-2020-3.2-19-20 ◽

2020 ◽

pp. 19-20

Author(s):

A.S. Bosnak

Keyword(s):

Abdominal Pain ◽

Contact Dermatitis ◽

Pregnant Women ◽

Hair Loss ◽

Cytotoxic Drugs ◽

The Other ◽

Target Cells ◽

Fetal Malformations ◽

Biological Liquids ◽

Waste Handling

Background. Cytotoxic drugs (CTD) are widely used in medicine for the treatment of tumors and other diseases. According to the definition, CTD are the drugs, which are toxic for cells, that is, interrupt their replication or growth. Effects of CTD are not targeted, that’s why when they get into the organism, they can harm not only target cells, but any other cells, and not only the patient, but also the other people who contact with them, especially, the healthcare workers (HCW). Objective. To define the risks of work with CTD. Materials and methods. Analysis of the literature data on this topic. Results and discussion. In case of breaking the safety rules, HCW may contact CTD. They can be exposed via skin contact, inhalation of aerosols or swallowing of the particles of CTD, via needle injuries. Actions and procedures, which can be accompanied by the contact of HCW with CTD, include drug preparation and administration, handling of drug containers and waste materials, handling the biological liquids of CTD-treated patient, cleaning of the spills or items, polluted by biological liquids. Exposure to CTD can result in the abdominal pain, hair loss, vomiting, liver injury, nasal sores, contact dermatitis and allergic reactions, miscarriages and fetal malformations (in pregnant women), changes in total blood analysis, mutations appearance. It is not proven that long occupational exposure to CTD leads to cancer, despite it is known that the majority of CTD have genotoxic, cancerogenic and mutagenic effects. Tactics of risk minimization in work with CTD includes definition of risk groups (pregnant women, newbies), assessment of the potential harms of used drugs, written fixation and often reassessment of risk estimation, HCW education. The latter must include methods of CTD preparation, peculiarities of CTD usage and waste handling, correct usage of individual protective equipment (IPE) etc. CTD must be prepared exclusively by the HCW, who underwent the adequate training, and in the specialized settings (HEPA-filtered exhaust systems, negative pressure rooms, absorbing surface covers). IPE must include vinyl or nitrile gloves, waterproof long-sleeved robe or overall with elastic cuffs, goggles or face shield, respirator, shoe covers. Potentially polluted by CTD waste must be collected into the polypropylene or polyethylene bags with the appropriate labeling. Conclusions. 1. CTD may harm not only target cells, but also the other cells, and not only patients, but all the other exposed people. 2. CTD exposure may lead to the abdominal pain, hair loss, vomiting, contact dermatitis, miscarriages and fetal malformations, etc. 3. There is a spectrum of protective measures to protect HCW from CTD exposure (IPE, equipment of specialized working places for CTD solutions’ preparation, correct waste handling).

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Severe Hair Loss of the Scalp due to a Hair Dye Containing Para phenylenediamine

ISRN Dermatology ◽

10.5402/2011/947284 ◽

2011 ◽

Vol 2011 ◽

pp. 1-2 ◽

Cited By ~ 13

Author(s):

Waka Ishida ◽

Teruhiko Makino ◽

Tadamichi Shimizu

Keyword(s):

Contact Dermatitis ◽

Allergic Contact Dermatitis ◽

Patch Test ◽

Hair Loss ◽

Skin Lesions ◽

Hair Dyes ◽

Hair Dye ◽

Systemic Corticosteroids ◽

Allergic Contact

We report the case of a 41-year-old female showing severe hair loss approximately 90% after the use of a hair dye. These symptoms developed six days after the use of a hair dye containing PPD. A patch test showed a (++) reaction at 48 h to 1% PPD in petrolatum, whereas all metals and white petrolatum were negative. She was therefore diagnosed with contact dermatitis due to PPD, resulting in hair loss. The skin lesions gradually improved after starting treatment with the systemic corticosteroids. The possibility that allergic contact dermatitis from hair dyes may be responsible for telogen effluvium should always be considered in a patient with increased hair loss.

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