Dorsal hand skin hyperpigmentation following oral olanzapine (Zyprexa) use

2018 ◽  
Vol 79 (4) ◽  
pp. 254-255 ◽  
Author(s):  
John H. Cary ◽  
Becky S. Li ◽  
Howard I. Maibach
Keyword(s):  
Skin Hyperpigmentation ◽  
Dorsal Hand ◽  
Oral Olanzapine

Island Radial Artery Fasciotendinous Flap for Dorsal Hand Reconstruction

2001 ◽  
Vol 47 (1) ◽  
pp. 83-85 ◽  
Author(s):  
R. Adani ◽  
L. Tarallo ◽  
I. Marcoccio
Keyword(s):  
Radial Artery ◽  
Hand Reconstruction ◽  
Dorsal Hand

scholarly journals Molecular and Biochemical Basis of Minocycline-Induced Hyperpigmentation—The Study on Normal Human Melanocytes Exposed to UVA and UVB Radiation

2021 ◽  
Vol 22 (7) ◽  
pp. 3755
Author(s):  
Jakub Rok ◽  
Zuzanna Rzepka ◽  
Justyna Kowalska ◽  
Klaudia Banach ◽  
Artur Beberok ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Therapeutic Potential ◽  
Melanin Synthesis ◽  
Uvb Radiation ◽  
Biochemical Basis ◽  
Skin Hyperpigmentation ◽  
Human Melanocytes ◽  
Anti Cancer ◽  
Normal Human

Minocycline is a drug which induces skin hyperpigmentation. Its frequency reaches up to 50% of treated patients. The adverse effect diminishes the great therapeutic potential of minocycline, including antibacterial, neuroprotective, anti-inflammatory and anti-cancer actions. It is supposed that an elevated melanin level and drug accumulation in melanin-containing cells are related to skin hyperpigmentation. This study aimed to evaluate molecular and biochemical mechanism of minocycline-induced hyperpigmentation in human normal melanocytes, as well as the contribution of UV radiation to this side effect. The experiments involved the evaluation of cyto- and phototoxic potential of the drug using cell imaging with light and confocal microscopes as well as biochemical and molecular analysis of melanogenesis. We showed that minocycline induced melanin synthesis in epidermal melanocytes. The action was intensified by UV irradiation, especially with the UVB spectrum. Minocycline stimulated the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase (TYR) gene. Higher levels of melanin and increased activity of tyrosinase were also observed in treated cells. Moreover, minocycline triggered the supranuclear accumulation of tyrosinase, similar to UV radiation. The decreased level of premelanosome protein PMEL17 observed in all minocycline-treated cultures suggests disorder of the formation, maturation or distribution of melanosomes. The study revealed that minocycline itself was able to enhance melanin synthesis. The action was intensified by irradiation, especially with the UVB spectrum. Demonstrated results confirmed the potential role of melanin and UV radiation minocycline-induced skin hyperpigmentation.

scholarly journals The impact of dialysis modality on skin hyperpigmentation in haemodialysis patients

2009 ◽  
Vol 24 (9) ◽  
pp. 2803-2809 ◽  
Author(s):  
S. J. Moon ◽  
D. K. Kim ◽  
J. H. Chang ◽  
C. H. Kim ◽  
H. W. Kim ◽  
...  
Keyword(s):  
Dialysis Modality ◽  
Skin Hyperpigmentation ◽  
The Impact

Cardiac conduction in females and males under intramuscular (IM) and oral olanzapine from schizophrenia clinical trials ECGs

2002 ◽  
Vol 12 ◽  
pp. 291-292
Author(s):  
J. Czekalla ◽  
C. Beasley ◽  
S. David ◽  
P.H. Berg ◽  
V. Stauffer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cardiac Conduction ◽  
Oral Olanzapine

scholarly journals Diameter, pressure and compliance relationships in dorsal hand veins

2001 ◽  
Vol 6 (2) ◽  
pp. 97-102 ◽  
Author(s):  
Barbara E Shykoff ◽  
Feras I Hawari ◽  
Joseph L Izzo
Keyword(s):  
Dorsal Hand
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