Characterising the potential for recall bias in anchor‐based MCID calculation of patient‐reported outcome measures for chronic rhinosinusitis

2020 ◽  
Vol 45 (5) ◽  
pp. 768-774
Author(s):  
Adam C. McCann ◽  
Katie M. Phillips ◽  
Michal Trope ◽  
David S. Caradonna ◽  
Stacey T. Gray ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Recall Bias ◽  
Patient Reported

Readability of patient‐reported outcome measures for chronic rhinosinusitis and skull base diseases

2019 ◽  
Vol 130 (10) ◽  
pp. 2305-2310
Author(s):  
Saangyoung E. Lee ◽  
Zainab Farzal ◽  
Adam J. Kimple ◽  
Brent A. Senior ◽  
Brian D. Thorp ◽  
...  
Keyword(s):  
Skull Base ◽  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Patient Reported

scholarly journals Patient-reported outcome measures for adult chronic rhinosinusitis: A systematic review and quality assessment

2015 ◽  
Vol 136 (6) ◽  
pp. 1532-1540.e2 ◽  
Author(s):  
Luke Rudmik ◽  
Claire Hopkins ◽  
Anju Peters ◽  
Timothy L. Smith ◽  
Rodney J. Schlosser ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Patient Reported

scholarly journals Evaluating metrics of responsiveness using patient-reported outcome measures in chronic rhinosinusitis

2016 ◽  
Vol 7 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Alcina K. Lidder ◽  
Kara Y. Detwiller ◽  
Caroline P.E. Price ◽  
Robert C. Kern ◽  
David B. Conley ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Patient Reported

Non-steroid, non-antibiotic anti-biofilm therapy for the treatment of chronic rhinosinusitis: a systematic review

2021 ◽  
Vol 135 (3) ◽  
pp. 196-205 ◽  
Author(s):  
A Taylor ◽  
J Fuzi ◽  
A Sideris ◽  
C Banks ◽  
T E Havas
Keyword(s):  
Systematic Review ◽  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Current Evidence ◽  
Current Evidence Base ◽  
Patient Reported ◽  
Symptom Scores

AbstractObjectiveChronic rhinosinusitis patients with biofilms cultured from their sinonasal cavity have greater symptom burden and risk of recalcitrant disease. A number of non-antibiotic, ‘anti-biofilm’ treatments exist which show anti-biofilm properties in preclinical studies. There is little evidence evaluating their impact on clinical symptom scores in chronic rhinosinusitis.MethodA systematic review was performed to assess the literature regarding the efficacy of non-steroid, non-antibiotic, anti-biofilm specific topical therapies in the treatment of chronic rhinosinusitis. The primary outcome assessed was change in validated patient reported outcome measures before and after anti-biofilm treatment.ResultsThirteen studies assessing the effect of anti-biofilm therapies in chronic rhinosinusitis through validated patient-reported outcome measures were included. Seven different anti-biofilm specific therapies for chronic rhinosinusitis were identified. None of the seven anti-biofilm therapies was identified as being confidently efficacious beyond placebo. Only one therapy (intranasal xylitol) showed a statistically significant reduction in symptom scores compared with placebo in more than one trial.ConclusionRobust evidence supporting the use of various anti-biofilm therapies in chronic rhinosinusitis is lacking. Further high quality, human, in vivo trials studying the effect of anti-biofilm therapies in chronic rhinosinusitis are needed to address the deficiencies of the current evidence base.

The Use of Postoperative Antibiotics Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis: A Systematic Review and Meta-analysis

2021 ◽  
pp. 194589242198914
Author(s):  
Chloe E. Swords ◽  
Jeremy J. Wong ◽  
Kara N. Stevens ◽  
Alkis J. Psaltis ◽  
Peter J. Wormald ◽  
...  
Keyword(s):  
Adverse Events ◽  
Chronic Rhinosinusitis ◽  
Outcome Measures ◽  
Endoscopic Sinus Surgery ◽  
Meta Analysis ◽  
Patient Reported Outcome Measures ◽  
Patient Reported Outcome ◽  
Sinus Surgery ◽  
Significant Difference ◽  
Patient Reported

Background Endoscopic sinus surgery is performed for medically recalcitrant chronic rhinosinusitis. There is no universally accepted strategy regarding post-operative antibiotics despite the high rates of usage worldwide. The aim of this study was to analyse patient-reported and objective outcomes behind antibiotic use following endoscopic sinus surgery. Methods A search of electronic databases was performed. Eligible randomised controlled trials (RCTs) and observational trials were included. The primary outcome was patient reported outcome measures. Secondary outcomes were local infections, endoscopy scores and adverse events. Meta-analysis was performed. Results Of 1045 publications identified, 7 were included in the qualitative synthesis and 5 RCTs were included in meta-analysis. Antibiotic regimens varied between studies in terms of antibiotic selection, timing commenced and duration of use. Meta-analysis suggested no significant difference between placebo and antibiotics in patient reported outcome measures (standardised mean difference (SMD) –0.215, 95% confidence interval (CI) –0.637 to 0.207) or endoscopic scores (SMD –2.86, 95% CI –0.846 to 0.273). There was no consistent definition in reporting of infection; therefore, this outcome cannot be comprehensively considered. No severe adverse events were attributable to antibiotics. Conclusions From the studies analysed, there is no level 1 evidence to suggest that antibiotics improved patient outcomes following sinus surgery. However, there was significant heterogeneity in outcome measures and no clear data exists regarding the effects of antibiotics on postoperative infections. The available evidence at present is not enough to make a recommendation in either direction. Further designed larger RCTs are required to investigate these questions in more detail.

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