Hidden hearing loss and tinnitus: Utility of the high‐definition audiograms in diagnosis

2019 ◽  
Vol 44 (6) ◽  
pp. 1170-1175 ◽  
Author(s):  
Jérôme Lefeuvre ◽  
Julie Chedeau ◽  
Marc Boulet ◽  
Gérald Fain ◽  
Jean‐François Papon ◽  
...  
Keyword(s):  
Hearing Loss ◽  
High Definition ◽  
Hidden Hearing Loss

scholarly journals Cochlear neuropathy in human presbycusis: Confocal analysis of hidden hearing loss in post-mortem tissue

2015 ◽  
Vol 327 ◽  
pp. 78-88 ◽  
Author(s):  
Lucas M. Viana ◽  
Jennifer T. O'Malley ◽  
Barbara J. Burgess ◽  
Dianne D. Jones ◽  
Carlos A.C.P. Oliveira ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Post Mortem ◽  
Hidden Hearing Loss ◽  
Cochlear Neuropathy

scholarly journals Contrasting mechanisms for hidden hearing loss: Synaptopathy vs myelin defects

2021 ◽  
Vol 17 (1) ◽  
pp. e1008499
Author(s):  
Maral Budak ◽  
Karl Grosh ◽  
Aritra Sasmal ◽  
Gabriel Corfas ◽  
Michal Zochowski ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Animal Models ◽  
Hair Cell ◽  
Auditory Nerve ◽  
Auditory Neuropathy ◽  
Biophysical Model ◽  
Spiral Ganglion Neuron ◽  
High Threshold ◽  
Type I ◽  
Hidden Hearing Loss

Hidden hearing loss (HHL) is an auditory neuropathy characterized by normal hearing thresholds but reduced amplitudes of the sound-evoked auditory nerve compound action potential (CAP). In animal models, HHL can be caused by moderate noise exposure or aging, which induces loss of inner hair cell (IHC) synapses. In contrast, recent evidence has shown that transient loss of cochlear Schwann cells also causes permanent auditory deficits in mice with similarities to HHL. Histological analysis of the cochlea after auditory nerve remyelination showed a permanent disruption of the myelination patterns at the heminode of type I spiral ganglion neuron (SGN) peripheral terminals, suggesting that this defect could be contributing to HHL. To shed light on the mechanisms of different HHL scenarios observed in animals and to test their impact on type I SGN activity, we constructed a reduced biophysical model for a population of SGN peripheral axons whose activity is driven by a well-accepted model of cochlear sound processing. We found that the amplitudes of simulated sound-evoked SGN CAPs are lower and have greater latencies when heminodes are disorganized, i.e. they occur at different distances from the hair cell rather than at the same distance as in the normal cochlea. These results confirm that disruption of heminode positions causes desynchronization of SGN spikes leading to a loss of temporal resolution and reduction of the sound-evoked SGN CAP. Another mechanism resulting in HHL is loss of IHC synapses, i.e., synaptopathy. For comparison, we simulated synaptopathy by removing high threshold IHC-SGN synapses and found that the amplitude of simulated sound-evoked SGN CAPs decreases while latencies remain unchanged, as has been observed in noise exposed animals. Thus, model results illuminate diverse disruptions caused by synaptopathy and demyelination on neural activity in auditory processing that contribute to HHL as observed in animal models and that can contribute to perceptual deficits induced by nerve damage in humans.

scholarly journals Persistent hair cell malfunction contributes to hidden hearing loss

2018 ◽  
Vol 361 ◽  
pp. 45-51 ◽  
Author(s):  
Wilhelmina H.A.M. Mulders ◽  
Ian L. Chin ◽  
Donald Robertson
Keyword(s):  
Hearing Loss ◽  
Hair Cell ◽  
Hidden Hearing Loss

scholarly journals Hidden hearing loss in patients with Charcot-Marie-Tooth disease type 1A

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Ji Eun Choi ◽  
Jin Myoung Seok ◽  
Jungmin Ahn ◽  
Yoon Sang Ji ◽  
Kyung Myun Lee ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Disease Type ◽  
Charcot Marie Tooth ◽  
Charcot Marie Tooth Disease ◽  
Hidden Hearing Loss ◽  
Tooth Disease

scholarly journals Using Thresholds in Noise to Identify Hidden Hearing Loss in Humans

2018 ◽  
Vol 39 (5) ◽  
pp. 829-844 ◽  
Author(s):  
Courtney L. Ridley ◽  
Judy G. Kopun ◽  
Stephen T. Neely ◽  
Michael P. Gorga ◽  
Daniel M. Rasetshwane
Keyword(s):  
Hearing Loss ◽  
Hidden Hearing Loss

Is there “hidden hearing loss” in patients with chronic rhinosinusitis?

2019 ◽  
Vol 59 (2) ◽  
pp. 124-131
Author(s):  
Shaolian Lin ◽  
Xi Lin ◽  
Shengnan Ye ◽  
Youhui Lin ◽  
Bo Shu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chronic Rhinosinusitis ◽  
Hidden Hearing Loss
Sign in / Sign up

Export Citation Format

Share Document