Efficacy of three proton‐pump inhibitor therapeutic strategies on laryngopharyngeal reflux disease; a prospective randomized double‐blind study

2019 ◽  
Vol 44 (4) ◽  
pp. 612-618 ◽  
Author(s):  
Young Hoon Yoon ◽  
Ki Wan Park ◽  
Seung Hun Lee ◽  
Hee Sung Park ◽  
Jae Won Chang ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Therapeutic Strategies ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Laryngopharyngeal Reflux Disease

Influence of Age on Treatment with Proton Pump Inhibitor in Patients with Laryngopharyngeal Reflux Disease

2013 ◽  
Vol 149 (2_suppl) ◽  
pp. P207-P207
Author(s):  
Young-Chan Lee ◽  
Seung-Woo Kim ◽  
Kee-Hwan Kwon ◽  
Young Gyu Eun
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease

A Randomized Clinical Trial of Proton Pump Inhibitors Combined with Traditional Chinese Medicine in the Treatment of Laryngopharyngeal Reflux Disease

2021 ◽  
Author(s):  
Feng Pei ◽  
Wei Jia Hu ◽  
Yi Nan Mao ◽  
Yu Liang Zhao
Keyword(s):  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Short Form ◽  
Therapeutic Effects ◽  
Reflux Symptom Index ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Group A ◽  
Group B

Background:To explore whether combined with TCM based on classical proton pumpinhibitors PPIs therapy can achieve better efficacy for patients withlaryngopharyngeal reflux disease. Methods: There were 150 laryngopharyngeal refluxpatients enrolled and divided into three groups randomly, with 50 cases in each group.Patients in group A were treated with the proton pump inhibitor (PPI) lansoprazole.Patients in group B were treated with lansoprazole combined with Banxia Houpudecoction, and patients in group C were treated with acupuncture treatments and acombination of Chinese and Western medicine. The reflux symptom index (RSI), refluxfinding score (RFS), and quality of life (36 item short form health survey questionnaire)were assessed before and 4 and 8 weeks after treatment. Results: The RSI and RFSscores of the three groups were significantly reduced after treatment (P < 0.001). Ingroup B and C, they were lower than in group A at 8 weeks (P < 0.01). The SF 36 scoreof 3 groups increased after treatment. At both 4 and 8 weeks (P < 0.001), and patientsin groups B and C scored higher than patients in group A (P < 0.001). The total effectiverate of group B and group C was higher than that of group A (P < 0.05). Conclusion:All three treatments have therapeutic effects on the disease, but the efficacy of a PPIalone is not as good as the combined treatments’ efficacies. Moreover, PPI combinedwith Banxia Houpu decoction and/or acupuncture treatment substantially affects lifeimprovement.

In response to Double-blind, placebo-controlled study with alginate suspension for laryngopharyngeal reflux disease

2018 ◽  
Vol 128 (10) ◽  
pp. E349-E350
Author(s):  
Jerome R. Lechien ◽  
Petros D. Karkos ◽  
Bernard Harmegnies ◽  
Sven Saussez
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Controlled Study ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Laryngopharyngeal Reflux Disease

Effects of Proton Pump Inhibitors in Patients with Laryngopharyngeal Reflux Disease

2011 ◽  
Vol 58 (110-111) ◽  
Author(s):  
Toshimi Chiba ◽  
Norihiko Kudara ◽  
Yukito Abiko ◽  
Masaki Endo ◽  
Kazuyuki Suzuki ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease
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