Modification of facial artery myomucosal flap: a novel perforator flap for upper aerodigestive tract reconstruction after head and neck cancer ablation

2016 ◽  
Vol 42 (4) ◽  
pp. 880-885 ◽  
Author(s):  
C.H. Baek ◽  
B.Y. Kim ◽  
W.R. Park ◽  
G.J. Lee ◽  
S.H. Woo ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Perforator Flap ◽  
Aerodigestive Tract ◽  
Facial Artery ◽  
Upper Aerodigestive Tract ◽  
Cancer Ablation ◽  
Myomucosal Flap

Follow-up strategies in head and neck cancer other than upper aerodigestive tract squamous cell carcinoma

2012 ◽  
Vol 270 (7) ◽  
pp. 1981-1989 ◽  
Author(s):  
Antoine Digonnet ◽  
Marc Hamoir ◽  
Guy Andry ◽  
Vincent Vander Poorten ◽  
Missak Haigentz ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Cancer ◽  
Squamous Cell ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract

scholarly journals Dysphagia, Speech, Voice, and Trismus following Radiotherapy and/or Chemotherapy in Patients with Head and Neck Carcinoma: Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-24 ◽  
Author(s):  
B. J. Heijnen ◽  
R. Speyer ◽  
B. Kertscher ◽  
R. Cordier ◽  
K. W. J. Koetsenruijter ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Oral Intake ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Treatment Protocols ◽  
Oncological Treatment

Introduction. Patients with head and neck cancer suffer from various impairments due to the primary illness, as well as secondary consequences of the oncological treatment. This systematic review describes the effects of radiotherapy and/or chemotherapy on the functions of the upper aerodigestive tract in patients with head and neck cancer.Methods. A systematic literature search was performed by two independent reviewers using the electronic databases PubMed and Embase. All dates up to May 2016 were included.Results. Of the 947 abstracts, sixty articles met the inclusion criteria and described one or more aspects of the sequelae of radiotherapy and/or chemotherapy. Forty studies described swallowing-related problems, 24 described voice-related problems, seven described trismus, and 25 studies described general quality of life. Only 14 articles reported that speech pathologists conducted the interventions, of which only six articles described in detail what the interventions involved.Conclusion. In general, voice quality improved following intervention, whereas quality of life, dysphagia, and oral intake deteriorated during and after treatment. However, as a consequence of the diversity in treatment protocols and patient characteristics, the conclusions of most studies cannot be easily generalised. Further research on the effects of oncological interventions on the upper aerodigestive tract is needed.

scholarly journals Polygenic Panels Predicting the Susceptibility of Multiple Upper Aerodigestive Tract Cancer in Oral Cancer Patients

2021 ◽  
Vol 11 (5) ◽  
pp. 425
Author(s):  
Huei-Tzu Chien ◽  
Chi-Chin Yeh ◽  
Chi-Kuang Young ◽  
Tzu-Ping Chen ◽  
Chun-Ta Liao ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Alcohol Drinking ◽  
Aerodigestive Tract ◽  
Multiple Primary Cancers ◽  
Upper Aerodigestive Tract ◽  
Primary Tumors ◽  
Multiple Primary

Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.

scholarly journals Office Assessment of Patient with Head and Neck Cancer

2010 ◽  
Vol 2 (1) ◽  
pp. 1-5
Author(s):  
Sultan Pradhan ◽  
Arsheed Hussain Hakeem
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Treatment Planning ◽  
Neck Cancer ◽  
Aerodigestive Tract ◽  
Head And Neck Cancers ◽  
Proper Treatment ◽  
Upper Aerodigestive Tract ◽  
Mucosal Surfaces ◽  
System Assessment

Abstract Evaluation of patients with head and neck cancers is important for proper treatment planning. With advent of advanced fiberoptic system, assessment of the mucosal surfaces of upper aerodigestive tract is much easier and can be performed in office settings.

Is there a role for flexible oesophagogastroscopy in upper aerodigestive tract squamous cell carcinoma?

2009 ◽  
Vol 124 (4) ◽  
pp. 417-419 ◽  
Author(s):  
T J Beech ◽  
M I Trotter ◽  
A L McDermott ◽  
W Mandal ◽  
A J Batch
Keyword(s):  
Squamous Cell Carcinoma ◽  
Head And Neck Cancer ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Patient Group ◽  
Squamous Cell ◽  
Aerodigestive Tract ◽  
Upper Aerodigestive Tract ◽  
Diagnostic Investigation

AbstractIntroduction:There is growing evidence to suggest that reflux (both laryngopharyngeal and gastroesophageal) has a role in the development of upper aerodigestive tract squamous cell carcinoma. This study discusses the role of identifying reflux in this patient group, and its prevalence.Methods:Prospective review of patients with head and neck cancer undergoing flexible oesophagogastroscopy as part of their diagnostic investigation.Results:Forty-five consecutive patients were identified. All patients were found to have evidence of oesophagitis, with 28 having oesophageal erosions and two Barrett's oesophagitis.Conclusion:Flexible oesophagogastroscopy is a useful test in patients with upper aerodigestive tract squamous cell carcinoma.

scholarly journals Oral Complications and Its Management during Radiotherapy

2011 ◽  
Vol 2 (2) ◽  
pp. 109-113 ◽  
Author(s):  
Dheeraj Kumar ◽  
Namrata Rastogi
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Oral Mucosa ◽  
Neck Cancer ◽  
Intensity Modulated Radiation Therapy ◽  
Upper Aerodigestive Tract ◽  
Conformal Radiation Therapy ◽  
Normal Tissues ◽  
Oral Complications

ABSTRACT Cancer is a class of diseases in which a cell or a group of cells display uncontrolled growth, invasion, and sometimes metastasis. The term head and neck cancer refers to a group of biologically similar cancers originating from the upper aerodigestive tract, including the lip, oral cavity, nasal cavity, paranasal sinuses, pharynx and larynx. About 90% of head and neck cancers are squamous cell carcinomas, originating from the mucosal lining (epithelium) of these regions. Radiation therapy is the most common form of treatment along with surgery and chemotherapy. There are different forms of radiation therapy, including 3D conformal radiation therapy, intensity-modulated radiation therapy and brachytherapy, which are commonly used in the treatment of cancers of the head and neck. There are both acute and long-term sequelae of radiation therapy (RT) for head and neck cancer (HNC) that occur because of effects on normal tissues. Radiotherapy-induced oral complications are complex, dynamic pathobiological processes that lower the quality of life and predispose patients to serious clinical disorders. Radiotherapy-induced damage in the oral mucosa is the result of the deleterious effects of radiation, not only on the oral mucosa itself but also on the adjacent salivary glands, bone, dentition, and masticatory musculature and apparatus. Dental surgeons should organize and implement preventive and therapeutic strategies in the management of various complications due to radiotherapy. The clinical features, diagnosis and management of various complications are discussed here. This article mainly presents a brief overview of the whole program of oral evaluation and proper care before, during and after the radiotherapy, managing all the common problems involved.

The Importance of Long-term Follow-up of Head and Neck Cancer Patients for Reliable Survival Analysis

2005 ◽  
Vol 133 (6) ◽  
pp. 877-881 ◽  
Author(s):  
Antonio Vitor Martins Priante ◽  
André Lopes Carvalho ◽  
Karina de Cássia Braga Ribeiro ◽  
Hirde Contesini ◽  
Luiz Paulo Kowalski
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Survival Time ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Survival Rates ◽  
Accurate Estimate ◽  
Upper Aerodigestive Tract ◽  
Lost To Follow Up

OBJECTIVE: Analyze the influence of patients lost to follow-up in estimated survival rates calculated by the Kaplan-Meier method. STUDY DESIGN: Only patients with previously untreated squamous cell carcinoma of the upper aerodigestive tract were selected. For the patients lost to follow-up anytime, the last medical evaluation date was collected to calculate the “estimate A” survival time. If the same patient returned to our outpatient clinic or further health information was obtained, the updated last information/evaluation date was also collected to calculate “estimate B” survival time. The survival curves considering “estimate A” and “B” survival rates were compared. RESULTS: The overall 5 and 10-years survival rates for all patients calculated for “estimate A” were 54.0% and 46.0%, respectively; compared with 42.8% and 28.2% when were calculated considering “estimate B” ( P < 0.001). CONCLUSION: Close follow-up of the head and neck cancer patients is essential for an accurate estimate of survival by KaplanMeier method. EBM RATING: C

scholarly journals Ubiquitin Carboxyl-Terminal Hydrolases and Human Malignancies: The Novel Prognostic and Therapeutic Implications for Head and Neck Cancer

2021 ◽  
Vol 10 ◽  
Author(s):  
Chao Rong ◽  
Ran Zhou ◽  
Shan Wan ◽  
Dan Su ◽  
Shou-Li Wang ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Drug Targets ◽  
The Novel ◽  
Deubiquitinating Enzymes ◽  
Upper Aerodigestive Tract ◽  
Term Survival ◽  
Clinical Prognosis ◽  
Therapeutic Implications

Ubiquitin C-terminal hydrolases (UCHs), a subfamily of deubiquitinating enzymes (DUBs), have been found in a variety of tumor entities and play distinct roles in the pathogenesis and development of various cancers including head and neck cancer (HNC). HNC is a heterogeneous disease arising from the mucosal epithelia of the upper aerodigestive tract, including different anatomic sites, distinct histopathologic types, as well as human papillomavirus (HPV)-positive and negative subgroups. Despite advances in multi-disciplinary treatment for HNC, the long-term survival rate of patients with HNC remains low. Emerging evidence has revealed the members of UCHs are associated with the pathogenesis and clinical prognosis of HNC, which highlights the prognostic and therapeutic implications of UCHs for patients with HNC. In this review, we summarize the physiological and pathological functions of the UCHs family, which provides enlightenment of potential mechanisms of UCHs family in HNC pathogenesis and highlights the potential consideration of UCHs as attractive drug targets.

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