scholarly journals Detection of putative stem cell markers, CD44/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas. A preliminary immunohistochemical andin vitrostudy

2015 ◽  
Vol 40 (4) ◽  
pp. 312-320 ◽  
Author(s):  
G. Mannelli ◽  
L. Magnelli ◽  
A. Deganello ◽  
M. Busoni ◽  
G. Meccariello ◽  
...  
Keyword(s):  
Stem Cell ◽  
Lymph Node ◽  
Head And Neck ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Stem Cell Markers ◽  
Cell Markers ◽  
Node Metastases ◽  
Putative Stem Cell

An expression profile for diagnosis of lymph node metastases from primary head and neck squamous cell carcinomas

2005 ◽  
Vol 37 (2) ◽  
pp. 182-186 ◽  
Author(s):  
Paul Roepman ◽  
Lodewyk F A Wessels ◽  
Nienke Kettelarij ◽  
Patrick Kemmeren ◽  
Antony J Miles ◽  
...  
Keyword(s):  
Lymph Node ◽  
Head And Neck ◽  
Expression Profile ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Node Metastases

scholarly journals Expression of LGR5, FZD7, TROY, and MIST1 in Perioperatively Treated Gastric Carcinomas and Correlation with Therapy Response

2019 ◽  
Vol 2019 ◽  
pp. 1-15
Author(s):  
Antonia Freiin Grote ◽  
Christine Halske ◽  
Hans-Michael Behrens ◽  
Sandra Krüger ◽  
Franziska Wilhelm ◽  
...  
Keyword(s):  
Stem Cell ◽  
Lymph Node ◽  
Cancer Stem Cell ◽  
Lymph Node Metastases ◽  
Cell Model ◽  
Stem Cell Markers ◽  
Primary Tumors ◽  
Cell Markers ◽  
Clinical Patient ◽  
Node Metastases

The cancer stem cell model is considered as a putative cause of resistance to chemotherapy and disease recurrence in malignant tumors. In this study, we tested the hypothesis that the response to neoadjuvant/perioperative chemotherapy correlates with the expression of four different putative cancer stem cell markers of gastric cancer (GC), i.e., LGR5, FZD7, TROY, and MIST1. The expression of LGR5, FZD7, TROY, and MIST1 was assessed by immunohistochemistry in 119 perioperatively treated GCs including pretherapeutic biopsies, resected primary GCs, and corresponding nodal and distant metastases. All four markers were detected in our cohort with variable prevalence and histoanatomical distributions. Few tumor cells expressed TROY. LGR5, FZD7, and MIST1 were coexpressed in 41.2% and completely absent in 6.2%. The prevalence of LGR5- and FZD7-positive GCs was higher and of TROY-positive GCs lower in perioperatively treated GCs compared with treatment-naïve tumors. LGR5, FZD7, and MIST1 in the primary tumors correlated significantly with their expression in the corresponding lymph node metastasis. An increased expression of LGR5 in primary GC correlated significantly with tumor regression. The expression of MIST1 in lymph node metastases correlated significantly with the number of lymph node metastases as well as overall and tumor-specific survival. FZD7 did not correlate with any clinicopathological patient characteristic. Our study on clinical patient samples shows that GCs may coexpress independently different stem cell markers; that neoadjuvant/perioperative treatment of GC significantly impacts on the expression of stem cell markers, which cannot be predicted by the analysis of pretherapeutic biopsies; and that their expression and tumor biological effect are heterogeneous and have to be viewed as a function of histoanatomical distribution.

scholarly journals Clinicopathological Risk Factors for Contralateral Lymph Node Metastases in Intraoral Squamous Cell Carcinoma: A Study of 331 Cases

2021 ◽  
Vol 28 (3) ◽  
pp. 1886-1898
Author(s):  
Christian Flörke ◽  
Aydin Gülses ◽  
Christina-Randi Altmann ◽  
Jörg Wiltfang ◽  
Henning Wieker ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Squamous Cell Carcinomas ◽  
Patient Specific ◽  
Infiltration Depth ◽  
Tumor Grading ◽  
Node Metastases

The current study aimed to examine the effects of clinicopathological factors, including the region, midline involvement, T classification, histological grade, and differentiation of the tumor on the rate of contralateral lymph node metastasis for oral squamous cell carcinoma and to assess their effects on survival rates. A total of 331 patients with intraoral squamous cell carcinomas were included. The influence of tumor location, T status, midline involvement, tumor grading, and the infiltration depth of the tumor on the pattern of metastasis was evaluated. Additionally, the effect of contralateral metastases on the prognosis was examined. Metastases of the contralateral side occurred most frequently in squamous cell carcinomas of the palate and floor of the mouth. Furthermore, tumors with a high T status resulted in significantly higher rates of contralateral metastases. Similarly, the midline involvement, tumor grading, existing ipsilateral metastases, and the infiltration depth of the tumor had a highly significant influence on the development of lymph node metastases on the opposite side. Oral squamous cell carcinomas require a patient-specific decision. There is an ongoing need for further prospective studies to confirm the validity of the prognostic factors described herein.

Advances in diagnostic modalities to detect occult lymph node metastases in head and neck squamous cell carcinoma

Head & Neck ◽  
2014 ◽  
Vol 37 (12) ◽  
pp. 1829-1839 ◽  
Author(s):  
Remco de Bree ◽  
Robert P. Takes ◽  
Jonas A. Castelijns ◽  
Jesus E. Medina ◽  
Sandro J. Stoeckli ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Neck Squamous Cell Carcinoma ◽  
Node Metastases ◽  
Diagnostic Modalities

scholarly journals Erratum: Accuracy of microRNAs as markers for the detection of neck lymph node metastases in patients with head and neck squamous cell carcinoma

BMC Medicine ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Ana Carolina de Carvalho ◽  
Cristovam Scapulatempo-Neto ◽  
Danielle Calheiros Campelo Maia ◽  
Adriane Feijó Evangelista ◽  
Mariana Andozia Morini ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Neck Squamous Cell Carcinoma ◽  
Neck Lymph Node ◽  
Node Metastases ◽  
Neck Lymph Node Metastases

Evaluation of the cancer stem cell marker DCLK1 in patients with lymph node metastases of head and neck cancer

2019 ◽  
Vol 215 (12) ◽  
pp. 152698
Author(s):  
Lorenz Kadletz ◽  
Lukas Kenner ◽  
Robert Wiebringhaus ◽  
Bernhard Jank ◽  
Christina Mayer ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Stem Cell ◽  
Lymph Node ◽  
Cancer Stem Cell ◽  
Head And Neck ◽  
Lymph Node Metastases ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Node Metastases
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