Pilot study assessing the efficacy of a novel treatment for sleep-related breathing disorders in patients undergoing sleep nasendoscopy: Our Experience

2014 ◽  
Vol 39 (3) ◽  
pp. 190-194 ◽  
Author(s):  
H. R.F. Powell ◽  
N. A. Watson ◽  
B. T. Kotecha
Keyword(s):  
Pilot Study ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Novel Treatment ◽  
Sleep Nasendoscopy

scholarly journals EXPRESS: Hypoxemia during Sleep and Overnight Rostral Fluid Shift in Pulmonary Arterial Hypertension: a pilot study

2021 ◽  
pp. 204589402199693
Author(s):  
Etienne-Marie Jutant ◽  
David Montani ◽  
Caroline Sattler ◽  
Sven Günther ◽  
Olivier Sitbon ◽  
...  
Keyword(s):  
Sleep Apnea ◽  
Pilot Study ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Central Sleep Apnea ◽  
The Body ◽  
Fluid Shift ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Pulmonary Arterial

Introduction. Sleep-related breathing disorders, including sleep apnea and hypoxemia during sleep, are common in pulmonary arterial hypertension (PAH), but the underlying mechanisms remain unknown. Overnight fluid shift from the legs to the upper airway and to the lungs promotes obstructive and central sleep apnea, respectively, in fluid retaining states. The main objective was to evaluate if overnight rostral fluid shift from the legs to the upper part of the body is associated with sleep-related breathing disorders in PAH. Methods. In a prospective study, a group of stable patients with idiopathic, heritable, related to drugs, toxins, or treated congenital heart disease PAH underwent a polysomnography and overnight fluid shift measurement by bioelectrical impedance in the month preceding or following a one-day hospitalization according to regular PAH follow-up schedule with a right heart catheterization. Results. Among 15 patients with PAH (women: 87%; median [25th;75th percentiles] age: 40 [32;61] years; mean pulmonary arterial pressure 56 [46;68] mmHg; pulmonary vascular resistance 8.8 [6.4;10.1] Wood units), 2 patients had sleep apnea and 8 (53%) had hypoxemia during sleep without apnea. The overnight rostral fluid shift was 168 [118;263] mL per leg. Patients with hypoxemia during sleep had a greater fluid shift (221 [141; 361] mL) than those without hypoxemia (118 [44; 178] mL, p = 0.045). Conclusion. This pilot study suggests that hypoxemia during sleep is associated with overnight rostral fluid shift in PAH.

A pilot study of sleep-related breathing disorders and hypersomnia in adult survivors of childhood Hodgkin lymphoma treated with thoracic radiation.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e21527-e21527
Author(s):  
Belinda Neal Mandrell ◽  
William Lewis ◽  
Susan Ogg ◽  
Merrill Wise ◽  
Daniel A. Mulrooney ◽  
...  
Keyword(s):  
Pilot Study ◽  
Hodgkin Lymphoma ◽  
Diagnostic Criteria ◽  
Adult Survivors ◽  
Morbidity And Mortality ◽  
Community Control ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Objective Evidence ◽  
Thoracic Radiation

e21527 Background: Survivors of childhood Hodgkin lymphoma (HL) often report fatigue and daytime sleepiness. The presence of sleep disorders, such as obstructive sleep apnea (OSA), could further increase cardiovascular and cerebrovascular morbidity and mortality in these patients. The purpose of this pilot study was to assess for the presence of sleep-related breathing disorders and hypersomnia in adult survivors of childhood HL treated with thoracic radiation. Methods: Survivors, ≥18 years of age and ≥10 years from diagnosis, were randomly selected from the St. Jude Lifetime Cohort (SJLIFE) study and assessed with nocturnal polysomnography (PSG) and the multiple sleep latency test (MSLT). Enrollment was stratified by body mass index (BMI) to include an equal number of normal weight and overweight/obese survivors. Survivors with a history of neurotoxicity related to cancer therapies, and neurological, genetic, or neurodevelopmental conditions associated with neurocognitive impairment were excluded. Results: Thirty adult survivors of childhood HL (60% male; 73% white; mean age 35.8 years [range,19.9-52.8]; BMI 28.6 [range, 18.2-43.5]) enrolled, and 14 (47%) met PSG criteria for mild or moderate OSA (OSA; apnea-hypopnea index 5-30). Of those with OSA, 11 had concurrent hypersomnia using the MSLT criteria and 3 of these 11 met diagnostic criteria for narcolepsy. Twelve (40%) had hypersomnia without OSA and 3 of these 12 met diagnostic criteria for narcolepsy. Within the cohort, 86% had objective evidence of OSA and/or hypersomnia/narcolepsy. Conclusions: Findings suggest adult survivors of childhood HL may be at increased risk for OSA, which when concurrent with treatment-related cardiopulmonary and cerebrovascular risk may further increase morbidity and mortality. Future studies are warranted to compare the prevalence of OSA in this population with a matched community control group and examine whether and how the mechanism for OSA might differ from that in the general population.

Late Breaking Abstract - Pilot study for a new diagnostic supply process for patients with sleep related breathing disorders

2018 ◽  
Author(s):  
Katharina Lederer ◽  
Sandra Zimmermann ◽  
Maria Haustein ◽  
Vivienne Gourdon ◽  
Bodo Weller ◽  
...  
Keyword(s):  
Pilot Study ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders

Validity Of Sleep Nasendoscopy in the Investigation of Sleep Related Breathing Disorders

2005 ◽  
Vol 115 (3) ◽  
pp. 538-540 ◽  
Author(s):  
S Berry ◽  
G Roblin ◽  
A Williams ◽  
A Watkins ◽  
H B. Whittet
Keyword(s):  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Sleep Nasendoscopy

Impact of sleep nasendoscopy on the outcome of mandibular advancement splint therapy in subjects with sleep-related breathing disorders

2007 ◽  
Vol 121 (7) ◽  
pp. 668-675 ◽  
Author(s):  
A Johal ◽  
M P Hector ◽  
J M Battagel ◽  
B T Kotecha
Keyword(s):  
Mandibular Advancement ◽  
Sleep Related Breathing Disorders ◽  
Splint Therapy ◽  
Sleep Studies ◽  
Mandibular Advancement Splint ◽  
Breathing Disorders ◽  
Obstructive Sleep ◽  
The Impact ◽  
Sleep Nasendoscopy

Aim: To evaluate the impact of positive sleep nasendoscopy, with simultaneous mandibular advancement, on the outcome of mandibular advancement splint therapy in 120 subjects with sleep-related breathing disorders.Methodology: Overnight polysomnography and sleep nasendoscopy were performed prior to splint therapy. Follow-up sleep studies, with the appliance in situ, were undertaken for those patients with obstructive sleep apnoea. Subjective outcome measures assessed daytime sleepiness and snoring.Results: One hundred and seven (89 per cent) subjects completed the study. Follow-up sleep studies confirmed the efficacy of treatment, with patients showing a mean reduction in apnoea/hypopnoea index (from 18.9 to 4.9, p<0.001), Epworth sleepiness scale scores (from 11 to seven, p<0.001) and partner-recorded snoring scores (from 14 to eight, p<0.001).Conclusion: Sleep nasendoscopy, with concomitant mandibular advancement to mimic the treatment effect, could be of prognostic value in determining successful mandibular advancement splint therapy.

The value of sleep nasendoscopy in the evaluation of patients with suspected sleep-related breathing disorders

1996 ◽  
Vol 21 (6) ◽  
pp. 485-489 ◽  
Author(s):  
T. SADAOKA ◽  
N. KAKITSUBA ◽  
Y. FUJIWARA ◽  
R. KANAI ◽  
H. TAKAHASHI
Keyword(s):  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Sleep Nasendoscopy

scholarly journals Comparison of Frequency and Severity of Sleep-Related Breathing Disorders in Children with Simple Obesity and Paediatric Patients with Prader–Willi Syndrome

2021 ◽  
Vol 11 (2) ◽  
pp. 141
Author(s):  
Agnieszka Lecka-Ambroziak ◽  
Marta Wysocka-Mincewicz ◽  
Anna Świercz ◽  
Małgorzata Jędrzejczak ◽  
Mieczysław Szalecki
Keyword(s):  
Insulin Resistance ◽  
Apnea Hypopnea Index ◽  
Oral Glucose ◽  
Prader Willi Syndrome ◽  
Model Assessment ◽  
Sleep Related Breathing Disorders ◽  
Breathing Disorders ◽  
Simple Obesity ◽  
Rhgh Treatment ◽  
Group 1

Sleep-related breathing disorders (SRBDs) can be present in children with simple obesity and with Prader–Willi syndrome (PWS) and influence an individual diagnostic and treatment approach. We compared frequency and severity of SRBDs in children with simple obesity and with PWS, both without and on recombinant human growth hormone (rhGH) treatment, and correlation of SRBDs with insulin resistance tests. A screening polysomnography-polygraphy (PSG), the oral glucose tolerance test (OGTT) and homeostasis model assessment of insulin resistance (HOMA-IR) were analysed in three groups of patients—with simple obesity (group 1, n = 30, mean age 14.2 years), patients with PWS without the rhGH therapy (group 2, n = 8, mean age 13.0 years) and during the rhGH treatment (group 3, n = 17, mean age 8.9 years). The oxygen desaturation index (ODI) was significantly higher in groups 2 and 3, compared to group 1 (p = 0.00), and hypopnea index (HI) was higher in group 1 (p = 0.03). Apnea–hypopnea index (AHI) and apnea index (AI) results positively correlated with the insulin resistance parameters in groups 1 and 3. The PSG values worsened along with the increasing insulin resistance in children with simple obesity and patients with PWS treated with rhGH that may lead to a change in the patients’ care.

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