Bradykinin‐mediated estrogen‐dependent depressor response by direct activation of female‐specific distribution of myelinated Ah‐type baroreceptor neurons in rats

Protein structure prediction and evaluation is one of the major fields of computational biology. Estimation of dihedral angle can provide information about the acceptability of both theoretically predicted and experimentally determined structures. Here we report on the sequence specific dihedral angle distribution of high resolution protein structures available in PDB and have developed Sasichandran, a tool for sequence specific dihedral angle prediction and structure evaluation. This tool will allow evaluation of a protein structure in pdb format from the sequence specific distribution of Ramachandran angles. Additionally, it will allow retrieval of the most probable Ramachandran angles for a given sequence along with the sequence specific data. Key words: Torsion angle, φ-ψ distribution, sequence specific ramachandran plot, Ramasekharan, protein structure appraisal D.O.I. 10.3329/ptcb.v19i2.5439 Plant Tissue Cult. & Biotech. 19(2): 217-226, 2009 (December)

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STUDIES ON THE MECHANISM OF NIDATION. XVI.

Acta Endocrinologica ◽

10.1530/acta.0.0490299 ◽

1965 ◽

Vol 49 (2) ◽

pp. 299-304 ◽

Cited By ~ 4

Author(s):

P. F. Kraicer ◽

M. C. Shelesnyak

Keyword(s):

Vaginal Smear ◽

Direct Activation

ABSTRACT One mg of ergocornine methanesulphate was injected into pseudopregnant rats; the time at which the vaginal smear became pro-oestrous was noted. Pro-oestrus appeared two days after the injection of ergocornine, independent of whether the drug was administered on days L1, L2, L3, L4 or L5 (L1 = first day of leucocytic vaginal smear). Injection of 5 mg/d progesterone delayed, but did not usually prevent, the onset of pro-oestrus. Pro-oestrus appeared 3 days after the last injection of progesterone. These results show that ergocornine induces the appearance of oestrus by effecting progesterone withdrawal rather than by direct activation of folliculotrophins.

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Selective disruption of ER[alpha] expression in dendritic cells of lupus prone mice results in female-specific reduced survival

Endocrine Abstracts ◽

10.1530/endoabs.54.p4 ◽

2018 ◽

Author(s):

Melissa A Cunningham ◽

Jena R Wirth ◽

Jackie Eudaly ◽

Gary S Gilkeson

Keyword(s):

Dendritic Cells ◽

Female Specific ◽

Er Alpha

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Fatty Liver and Impaired Hepatic Metabolism Alters the Congener-Specific Distribution of Polychlorinated Biphenyls (PCBs) in Mice with a Liver-Specific Deletion of Cytochrome P450 Reductase

10.26434/chemrxiv.12026904.v1 ◽

2020 ◽

Author(s):

Xueshu Li ◽

Chun-Yun Zhang ◽

Hans-Joachim Lehmler

Keyword(s):

Cytochrome P450 ◽

Polychlorinated Biphenyls ◽

Fatty Liver ◽

Partition Coefficients ◽

Hepatic Metabolism ◽

Gas Chromatography Mass Spectrometry ◽

Cytochrome P450 Reductase ◽

P450 Reductase ◽

Specific Distribution ◽

Specific Deletion

Polychlorinated biphenyls (PCBs) are persistent organic pollutants that are linked to adverse health outcomes. PCB tissue levels are determinants of PCB toxicity; however, it is unclear how factors, such as an altered metabolism and/or a fatty liver, affect PCB distribution in vivo. We determined the congener-specific disposition of PCBs in mice with a liver specific deletion of cytochrome P450 reductase (KO), a model of fatty liver with impaired hepatic metabolism, and wildtype (WT) mice. Male and female KO and WT mice were exposed orally to Aroclor 1254, a technical PCB mixture. PCBs were quantified in adipose, blood, brain and liver tissues by gas chromatography-mass spectrometry. PCB profiles and levels in tissues were genotype and sex dependent. PCB levels were higher in the liver from KO compared to WT mice. PCB profiles showed clear differences between tissues from the same exposure group. While experimental tissue : blood partition coefficients in KO and WT mice did not follow the trends predicted using a composition-based model, the agreement between experimental and calculated partition coefficients was still reasonable. Thus, a fatty liver and/or an impaired hepatic metabolism alter the distribution of PCBs in mice and the magnitude of the partitioning of PCBs from blood into tissues can be approximated using composition-based models.<br>

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