scholarly journals Urinary albumin creatinine ratio associated with postoperative delirium in elderly patients undergoing elective non‐cardiac surgery: A prospective observational study

2021 ◽  
Author(s):  
Hui‐Lian Guan ◽  
He Liu ◽  
Xiao‐Yi Hu ◽  
Mannan Abdul ◽  
Ming‐Sheng Dai ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Elderly Patients ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Albumin Creatinine Ratio

scholarly journals Evaluation of spot urinary albumin - creatinine ratio as a screening tool in the prediction of pre-eclampsia in early pregnancy: a pilot study

2020 ◽  
Vol 9 (2) ◽  
pp. 575
Author(s):  
Rajeshwari G. ◽  
Akshaya Girish Dongare ◽  
G. L. Patil ◽  
Tejaswi Pujar
Keyword(s):  
Prospective Observational Study ◽  
Screening Tool ◽  
Urinary Albumin ◽  
Creatinine Ratio ◽  
Perinatal Morbidity ◽  
Singleton Pregnancy ◽  
Chi Square ◽  
Albumin Creatinine Ratio ◽  
Chi Square Test ◽  
Student’S T

Background: Pre-eclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in India. Objective of this study was to establish whether a spot urinary albumin/creatinine ratio (ACR) measured between 18-28 weeks of gestation can predict subsequent pre-eclampsia in asymptomatic pregnant women.Methods: A prospective observational study involving 50 registered antenatal cases visiting the obstetrics outpatient department between 18-28 weeks of singleton pregnancy with nil proteinuria upon dipstick measurement were included. ACR was determined from random single midstream urine sample. Statistical analysis was performed using Chi square test and Student’s t-test.Results: Of the study group, 10 patients had high ACR value, with 8(80%) developed pre-eclampsia and 2(20%) remained normotensive. ACR had a sensitivity of 80%, specificity 97.56%, positive predictive value of 88.89%, diagnostic accuracy of the test being 94.12%.Conclusions: The spot urinary protein creatinine ratio is a reliable predictor for pre-eclampsia in pregnancy.

scholarly journals Elevated Procalcitonin as a Risk Factor for Postoperative Delirium in the Elderly after Cardiac Surgery—A Prospective Observational Study

2020 ◽  
Vol 9 (12) ◽  
pp. 3837
Author(s):  
Anna Kupiec ◽  
Barbara Adamik ◽  
Natalia Kozera ◽  
Waldemar Gozdzik
Keyword(s):  
Cardiac Surgery ◽  
Depressive Symptoms ◽  
Elderly Patients ◽  
Odds Ratio ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Reference Range ◽  
The Elderly ◽  
Daily Functioning ◽  
Multivariable Logistic Regression Model

One of the most common complications after cardiac surgery with cardiopulmonary bypass (CBP) is delirium. The purpose of this study was to prospectively investigate the risk of developing postoperative delirium in a group of elderly patients using a multivariate assessment of preoperative and intraoperative risk factors. A total of 149 elderly patients were included. Thirty patients (20%) developed post-operative delirium. Preoperative procalcitonin (PCT) above the reference range (>0.05 ng/mL) was recorded more often in patients who postoperatively developed delirium than in the non-delirium group (50% vs. 27%, p = 0.019). After surgery, PCT was significantly higher in the delirium than the non-delirium group: ICU admission after surgery: 0.08 ng/mL vs. 0.05 ng/mL p = 0.011), and for consecutive days (day 1: 0.59 ng/mL vs. 0.25 ng/mL, p = 0.003; day 2: 1.21 ng/mL vs. 0.36 ng/mL, p = 0.006; day 3: 0.76 ng/mL vs. 0.34 ng/mL, p = 0.001). Patients with delirium were older (74 vs. 69 years, p = 0.038), more often had impaired daily functioning (47% vs. 28%, p = 0.041), depressive symptoms (40% vs. 17%, p = 0.005), and anemia (43% vs. 19%, p = 0.006). In a multivariable logistic regression model, preoperative procalcitonin (odds ratio (OR) = 3.05), depressive symptoms (OR = 5.02), age (OR = 1.14), impaired daily functioning (OR = 0.76) along with CPB time (OR = 1.04) were significant predictors of postoperative delirium.

scholarly journals Intraoperative burst suppression is associated with postoperative delirium following cardiac surgery: a prospective, observational study

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Martin Soehle ◽  
Alexander Dittmann ◽  
Richard K Ellerkmann ◽  
Georg Baumgarten ◽  
Christian Putensen ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Burst Suppression

scholarly journals Association between preoperative serum homocysteine and delayed neurocognitive recovery after non-cardiac surgery in elderly patients: a prospective observational study

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhen-Feng Zhang ◽  
Qing-Chun Sun ◽  
Yi-Fan Xu ◽  
Ke Ding ◽  
Meng-Meng Dong ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Observational Study ◽  
Elderly Patients ◽  
Sex Education ◽  
Prospective Observational Study ◽  
Cognitive Disorders ◽  
Vitamin B ◽  
Link Type ◽  
Preoperative Serum ◽  
Increased Risk

Abstract Background Homocysteine, folate, and vitamin B12 involved in 1-carbon metabolism are associated with cognitive disorders. We sought to investigate the relationships between these factors and delayed neurocognitive recovery (dNCR) after non-cardiac surgery. Methods This was a prospective observational study of patients (n = 175) who were ≥ 60 years of age undergoing non-cardiac surgery. Patients were evaluated preoperatively and for 1 week postoperatively by using neuropsychological tests and were divided into dNCR or non-dNCR groups according to a Z-score ≤ − 1.96 on at least two of the tests. The relationship between the occurrence of dNCR and preoperative levels of homocysteine, folate, and vitamin B12 was analyzed. Univariate and multivariable logistic regression analyses were conducted to identify factors associated with dNCR. Results Delayed neurocognitive recovery was observed in 36 of 175 patients (20.6%; 95% confidence interval [CI], 14.5–26.6%) 1 week postoperatively. Patients who developed dNCR had significantly higher median [interquartile range (IQR)] homocysteine concentrations (12.8 [10.9,14.4] μmol/L vs 10.6 [8.6,14.7] μmol/L; P = 0.02) and lower folate concentrations (5.3 [4.2,7.3] ng/mL vs 6.9 [5.3,9.5] ng/mL; P = 0.01) than those without dNCR. Compared to the lowest tertile, the highest homocysteine tertile predicted dNCR onset (odds ratio [OR], 3.9; 95% CI, 1. 3 to 11.6; P = 0.02), even after adjusting for age, sex, education, and baseline Mini Mental State Examination. Conclusions Elderly patients with high homocysteine levels who underwent general anesthesia for non-cardiac surgery have an increased risk of dNCR. This knowledge could potentially assist in the development of preventative and/or therapeutic measures. Trial registration NCT03084393 (https://www.clinicaltrials.gov)

scholarly journals Hallucinations after Cardiac Surgery: A Prospective Observational Study

Medicina ◽  
2020 ◽  
Vol 56 (3) ◽  
pp. 104
Author(s):  
Thomas H. Ottens ◽  
Iris E.C. Sommer ◽  
Marieke J. Begemann ◽  
Maya Schutte ◽  
Maarten Jan Cramer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Cardiac Surgery ◽  
Observational Study ◽  
Postoperative Delirium ◽  
Prospective Observational Study ◽  
Common Type ◽  
Control Group ◽  
Visual Hallucinations ◽  
Psychotic Experiences

Background and Objective: Hallucinations after cardiac surgery can be a burden, but their prevalence and phenomenology have not been studied well. Risk factors for postoperative hallucinations, as well as their relation to delirium are unclear. We aimed to study the prevalence and phenomenology of hallucinations after cardiac surgery, and to study the association between hallucinations and delirium in this population. Materials and Methods: We used the Questionnaire for Psychotic Experiences to detect hallucinations in cardiac surgery patients and a control group of cardiology outpatients. We assessed postoperative delirium with validated instruments. Risk factors for postoperative hallucinations and the association between hallucinations and delirium were analysed using logistic regression. Results: We included 201 cardiac surgery patients and 99 cardiology outpatient controls. Forty-four cardiac surgery patients (21.9%) experienced postoperative hallucinations in the first four postoperative days. This was significantly higher compared to cardiology outpatient controls (n = 4, 4.1%, p < 0.001). Visual hallucinations were the most common type of hallucinations in cardiac surgery patients, and less common in outpatient controls. Cardiac surgery patients who experienced hallucinations were more likely to also have delirium (10/44, 22.7%) compared to patients without postoperative hallucinations (16/157, 10.2% p = 0.03). However, the majority of patients with postoperative hallucinations (34/44, 77.3%) did not develop delirium. Conclusion: After cardiac surgery, hallucinations occurred more frequently than in outpatient controls. Hallucinations after cardiac surgery were most often visual in character. Although postoperative hallucinations were associated with delirium, most patients with hallucinations did not develop delirium.

Sign in / Sign up

Export Citation Format

Share Document