scholarly journals Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II‐infused mice

2021 ◽  
Author(s):  
Jie Wang ◽  
Xiao‐qin Tang ◽  
Min Xia ◽  
Cheng‐cheng Li ◽  
Chao Guo ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Intracerebral Hemorrhage ◽  
Iron Chelation ◽  
Secondary Bleeding

scholarly journals Ferric iron chelation lowers brain iron levels after intracerebral hemorrhage in rats but does not improve outcome

2012 ◽  
Vol 234 (1) ◽  
pp. 136-143 ◽  
Author(s):  
Angela M. Auriat ◽  
Gergely Silasi ◽  
Zhouping Wei ◽  
Rosalie Paquette ◽  
Phyllis Paterson ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Ferric Iron ◽  
Iron Chelation ◽  
Brain Iron ◽  
Improve Outcome

Long-term effects of experimental intracerebral hemorrhage: the role of iron

2006 ◽  
Vol 104 (2) ◽  
pp. 305-312 ◽  
Author(s):  
Ya Hua ◽  
Takehiro Nakamura ◽  
Richard F. Keep ◽  
Jimin Wu ◽  
Timothy Schallert ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Brain Atrophy ◽  
Iron Chelation ◽  
Tissue Loss ◽  
Neurological Deficits ◽  
Sprague Dawley ◽  
Long Term Effects ◽  
Autologous Whole Blood ◽  
Hemoglobin Degradation

Object Intracerebral hemorrhage (ICH) causes brain atrophy and neurological deficits. The mechanisms of brain atrophy after ICH are poorly understood, although recent evidence suggests that some ICH-induced brain injury results from the products of hemoglobin degradation, including iron. In this study the authors examine the role of iron in brain atrophy and neurological deficits following ICH. Methods Male Sprague–Dawley rats received an infusion of either 100 μl autologous whole blood or saline into the right caudate. Hematoxylin and eosin staining was used for histological examination, and iron levels and ferritin immunoreactivities were also examined. Deferoxamine was used as an iron chelator. Over the duration of the experiment, the rats underwent behavioral testing (forelimb placing, forelimb use asymmetry, and corner turn tests). Brain atrophy in the caudate with prolonged neurological deficits occurred after ICH. Although partial functional recovery occurred with time, residual neurological deficits were still detectable at 3 months postprocedure. Iron accumulation and ferritin upregulation were present in the ipsilateral caudate. Deferoxamine reduced brain atrophy and improved behavioral outcomes, and it also reduced brain ferritin immunoreactivity. Conclusions An ICH results in an accumulation of iron in the brain that is not cleared within 3 months and that contributes to brain tissue loss and neurological deficits posthemorrhage. Iron chelation may be a useful therapy for patients with ICH.

scholarly journals Secondary Bleeding During Acute Experimental Intracerebral Hemorrhage

Stroke ◽  
2019 ◽  
Vol 50 (5) ◽  
pp. 1210-1215 ◽  
Author(s):  
Frieder Schlunk ◽  
Maximilian Böhm ◽  
Gregoire Boulouis ◽  
Tao Qin ◽  
Michal Arbel ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Secondary Bleeding

scholarly journals Iron Chelation Suppresses Ferritin Upregulation and Attenuates Vascular Dysfunction in the Aorta of Angiotensin II–Infused Rats

2005 ◽  
Vol 25 (11) ◽  
pp. 2282-2288 ◽  
Author(s):  
Nobukazu Ishizaka ◽  
Kan Saito ◽  
Ichiro Mori ◽  
Gen Matsuzaki ◽  
Minoru Ohno ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Vascular Dysfunction ◽  
Iron Chelation

Iron chelation and a free radical scavenger suppress angiotensin II-induced downregulation ofklotho, an anti-aging gene, in rat

FEBS Letters ◽  
2003 ◽  
Vol 551 (1-3) ◽  
pp. 58-62 ◽  
Author(s):  
Kan Saito ◽  
Nobukazu Ishizaka ◽  
Haruo Mitani ◽  
Minoru Ohno ◽  
Ryozo Nagai
Keyword(s):  
Free Radical ◽  
Angiotensin Ii ◽  
Iron Chelation ◽  
Free Radical Scavenger ◽  
Radical Scavenger

scholarly journals Systemic Up-Regulation of Angiotensin II Type 1 Receptor in Cardiac Donors with Spontaneous Intracerebral Hemorrhage

2004 ◽  
Vol 4 (7) ◽  
pp. 1097-1102 ◽  
Author(s):  
Mohamad H. Yamani ◽  
Daniel J. Cook ◽  
E. Murat Tuzcu ◽  
Ashraf Abdo ◽  
Philip Paul ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Intracerebral Hemorrhage ◽  
Spontaneous Intracerebral Hemorrhage

Activator protein-1 is necessary for angiotensin-II stimulation of human adrenocorticotropin receptor gene transcription

2001 ◽  
Vol 268 (6) ◽  
pp. 1802-1810
Author(s):  
Danielle Naville ◽  
Estelle Bordet ◽  
Marie-Claude Berthelon ◽  
Philippe Durand ◽  
Martine Begeot
Keyword(s):  
Angiotensin Ii ◽  
Gene Transcription ◽  
Receptor Gene ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
Stimulation Of
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