scholarly journals CpG methylation signature defines human temporal lobe epilepsy and predicts drug‐resistant

2020 ◽  
Vol 26 (10) ◽  
pp. 1021-1030
Author(s):  
Wenbiao Xiao ◽  
Chaorong Liu ◽  
Kuo Zhong ◽  
Shangwei Ning ◽  
Rui Hou ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cpg Methylation ◽  
Drug Resistant ◽  
Human Temporal Lobe

CpG Methylation Signature Define Human Temporal Lobe Epilepsy and Predict Drug-Resistant

2019 ◽  
Author(s):  
Wenbiao Xiao ◽  
Chaorong Liu ◽  
Kuo Zhong ◽  
Shangwei Ning ◽  
Rui Hou ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Cpg Methylation ◽  
Drug Resistant ◽  
Human Temporal Lobe

scholarly journals Increased Reelin Promoter Methylation Is Associated With Granule Cell Dispersion in Human Temporal Lobe Epilepsy

2009 ◽  
Vol 68 (4) ◽  
pp. 356-364 ◽  
Author(s):  
Katja Kobow ◽  
Ina Jeske ◽  
Michelle Hildebrandt ◽  
Jan Hauke ◽  
Eric Hahnen ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Granule Cell ◽  
Promoter Methylation ◽  
Cell Dispersion ◽  
Human Temporal Lobe

Survival of mossy cells of the hippocampal dentate gyrus in humans with mesial temporal lobe epilepsy

2009 ◽  
Vol 111 (6) ◽  
pp. 1237-1247 ◽  
Author(s):  
László Seress ◽  
Hajnalka Ábrahám ◽  
Zsolt Horváth ◽  
Tamás Dóczi ◽  
József Janszky ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Dentate Gyrus ◽  
Temporal Lobe ◽  
Pyramidal Neurons ◽  
Hippocampal Sclerosis ◽  
Mesial Temporal Lobe Epilepsy ◽  
Drug Resistant ◽  
Hippocampal Dentate Gyrus ◽  
Mossy Cells ◽  
Mesial Temporal Lobe

Object Hippocampal sclerosis can be identified in most patients with mesial temporal lobe epilepsy (TLE). Surgical removal of the sclerotic hippocampus is widely performed to treat patients with drug-resistant mesial TLE. In general, both epilepsy-prone and epilepsy-resistant neurons are believed to be in the hippocampal formation. The hilar mossy cells of the hippocampal dentate gyrus are usually considered one of the most vulnerable types of neurons. The aim of this study was to clarify the fate of mossy cells in the hippocampus in epileptic humans. Methods Of the 19 patients included in this study, 15 underwent temporal lobe resection because of drug-resistant TLE. Four patients were used as controls because they harbored tumors that had not invaded the hippocampus and they had experienced no seizures. Histological evaluation of resected hippocampal tissues was performed using immunohistochemistry. Results Mossy cells were identified in the control as well as the epileptic hippocampi by using cocaine- and amphetamine-regulated transcript peptide immunohistochemistry. In most cases the number of mossy cells was reduced and thorny excrescences were smaller in the epileptic hippocampi than in controls; however, there was a significant loss of pyramidal cells and a partial loss of granule cells in the same epileptic hippocampi in which mossy cell loss was apparent. The loss of mossy cells could be correlated with the extent of hippocampal sclerosis, patient age at seizure onset, duration of epilepsy, and frequency of seizures. Conclusions In many cases large numbers of mossy cells were present in the hilus of the dentate gyrus when most pyramidal neurons of the CA1 and CA3 areas of the Ammon's horn were lost, suggesting that mossy cells may not be more vulnerable to epileptic seizures than the hippocampal pyramidal neurons.

Ictal fear is associated with anxiety symptoms and interictal dysphoric disorder in drug-resistant mesial temporal lobe epilepsy

2021 ◽  
Vol 115 ◽  
pp. 107548
Author(s):  
Hiago Murilo Melo ◽  
Ricardo Guarnieri ◽  
Helena Dresch Vascouto ◽  
Douglas Afonso Formolo ◽  
Cristiane Ribeiro de Carvalho ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Anxiety Symptoms ◽  
Drug Resistant ◽  
Mesial Temporal Lobe

GABAB(1) mRNA expression in hippocampal sclerosis associated with human temporal lobe epilepsy

2001 ◽  
Vol 86 (1-2) ◽  
pp. 84-89 ◽  
Author(s):  
Andrew Billinton ◽  
Virginia H. Baird ◽  
Maria Thom ◽  
John S. Duncan ◽  
Neil Upton ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Mrna Expression ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Human Temporal Lobe

Characterization of neurons in the cortical white matter in human temporal lobe epilepsy

Neuroscience ◽  
2016 ◽  
Vol 333 ◽  
pp. 140-150 ◽  
Author(s):  
Zsófia Richter ◽  
József Janszky ◽  
György Sétáló ◽  
Réka Horváth ◽  
Zsolt Horváth ◽  
...  
Keyword(s):  
White Matter ◽  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Human Temporal Lobe
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