scholarly journals Lower serum interleukin‐22 and interleukin‐35 levels are associated with disease status in neuromyelitis optica spectrum disorders

2019 ◽  
Vol 26 (2) ◽  
pp. 251-259
Author(s):  
Hong Yang ◽  
Lu Han ◽  
Yun‐Jia Zhou ◽  
Jie Ding ◽  
Yu Cai ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Disease Status ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Lower Serum ◽  
Interleukin 22 ◽  
Spectrum Disorders

Lymphocyte Subsets Are Associated with Disease Status in Neuromyelitis Optica Spectrum Disorders

2021 ◽  
pp. 1-10
Author(s):  
Hong Yang ◽  
Wei Liu ◽  
Yi-Fan Wu ◽  
De-Sheng Zhu ◽  
Xia-Feng Shen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
B Cells ◽  
Neuromyelitis Optica ◽  
Peripheral Blood ◽  
Lymphocyte Subsets ◽  
Disease Status ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spinal Cord Lesions ◽  
Cross Sectional ◽  
Spectrum Disorders

<b><i>Objective:</i></b> At present, studies on lymphocytes are mostly conducted on CD19<sup>+</sup> B cells and CD27<sup>+</sup> B cells in neuromyelitis optica spectrum disorders (NMOSDs), but the exact changes in lymphocyte subsets (CD19<sup>+</sup> B cells, CD3<sup>+</sup> T cells, CD4<sup>+</sup> Th cells, CD8<sup>+</sup> Ts cells, the CD4<sup>+</sup>/CD8<sup>+</sup> ratio, and NK [CD56+ CD16] cells) have rarely been studied. This study aimed to assess lymphocyte subset changes in patients with NMOSD. <b><i>Methods:</i></b> We performed a cross-sectional study of consecutive patients with acute NMOSD (<i>n</i> = 41), chronic NMOSD (<i>n</i> = 21), and healthy individuals (<i>n</i> = 44). Peripheral blood samples were obtained upon admission, and lymphocyte subsets were analyzed by flow cytometry. Levels of lymphocyte subsets among 3 groups were compared and its correlation with the length of spinal cord lesions was analyzed. <b><i>Results:</i></b> The levels of peripheral blood CD19<sup>+</sup> B cells were significantly higher in patients with acute and chronic NMOSD than in healthy controls (HCs) (17.91 ± 8.7%, 13.08 ± 7.562%, and 12.48 ± 3.575%, respectively; <i>p</i> &#x3c; 0.001) and were positively correlated with the length of spinal cord lesions in acute NMOSD (<i>r</i> = 0.433, <i>p</i> &#x3c; 0.05). The peripheral blood CD4<sup>+</sup>/CD8<sup>+</sup> ratio was significantly lower in patients with acute NMOSD and chronic NMOSD than in HCs (1.497 ± 0.6387, 1.33 ± 0.5574, and 1.753 ± 0.659, respectively; <i>p</i> &#x3c; 0.05), and the levels of peripheral blood NK (CD56+ CD16) cells were significantly lower in patients with acute and chronic NMOSD than in HCs (13.6 ± 10.13, 11.11 ± 7.057, and 14.7 [interquartile range = 9.28], respectively; <i>p</i> &#x3c; 0.01). <b><i>Conclusions:</i></b> The levels of certain subsets of peripheral blood lymphocytes are associated with disease status in NMOSD.

P 855. Epidemiology of Neuromyelitis Optica Spectrum Disorders in Children and Adolescents

2018 ◽  
Author(s):  
Christian Lechner ◽  
Matthias Baumann ◽  
Eva-Maria Hennes ◽  
Kathrin Schanda ◽  
Markus Reindl ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Neuromyelitis Optica ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders

Olfactory dysfunction in neuromyelitis optica spectrum disorders

2015 ◽  
Vol 262 (8) ◽  
pp. 1890-1898 ◽  
Author(s):  
Lin-Jie Zhang ◽  
Ning Zhao ◽  
Ying Fu ◽  
Da-Qi Zhang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Neuromyelitis Optica ◽  
Olfactory Dysfunction ◽  
Neuromyelitis Optica Spectrum Disorders ◽  
Spectrum Disorders
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