scholarly journals Vascular endothelial growth factor activates neural stem cells through epidermal growth factor receptor signal after spinal cord injury

2018 ◽  
Vol 25 (3) ◽  
pp. 375-385 ◽  
Author(s):  
Su‐Mei Liu ◽  
Zhi‐Feng Xiao ◽  
Xing Li ◽  
Yan‐Nan Zhao ◽  
Xian‐Ming Wu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Growth Factor Receptor ◽  
Vascular Endothelial ◽  
Receptor Signal ◽  
Cord Injury ◽  
Epidermal Growth ◽  
Endothelial Growth Factor

scholarly journals Vascular Endothelial Growth Factor and Spinal Cord Injury Pain

2010 ◽  
Vol 27 (10) ◽  
pp. 1793-1803 ◽  
Author(s):  
Olivera Nesic ◽  
Laura M. Sundberg ◽  
Juan J. Herrera ◽  
Venkata U.L. Mokkapati ◽  
Julieann Lee ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Endothelial ◽  
Cord Injury ◽  
Endothelial Growth Factor ◽  
Spinal Cord Injury Pain

scholarly journals Upregulation of Vascular Endothelial Growth Factor Receptors Flt-1 and Flk-1 Following Acute Spinal Cord Contusion in Rats

2007 ◽  
Vol 55 (8) ◽  
pp. 821-830 ◽  
Author(s):  
Jeong-Sun Choi ◽  
Ha-Young Kim ◽  
Jung-Ho Cha ◽  
Jae-Youn Choi ◽  
Sang In Park ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Reactive Astrocytes ◽  
Pcr Analysis ◽  
Vascular Endothelial ◽  
Cord Injury ◽  
Contusion Injury ◽  
Endothelial Growth Factor

To investigate the possible role of vascular endothelial growth factor (VEGF) in the injured spinal cord, we analyzed the distribution and time course of the two tyrosine kinase receptors for VEGF, Flt-1 and Flk-1, in the rat spinal cord following contusion injury using a weight-drop impactor. The semi-quantitative RT-PCR analysis of Flt-1 and Flk-1 in the spinal cord showed slight upregulation of these receptors following spinal cord injury. Although mRNAs for Flt-1 and Flk-1 were constitutively expressed in neurons, vascular endothelial cells, and some astrocytes in laminectomy control rats, their upregulation was induced in association with microglia/macrophages and reactive astrocytes in the vicinity of the lesion within 1 day in rats with a contusion injury and persisted for at least 14 days. The spatiotemporal expression of Flt-1 in the contused spinal cord mirrored that of Flk-1 expression. In the early phase of spinal cord injury, upregulation of Flt-1 and Flk-1 mRNA occurred in microglia/macrophages that infiltrated the lesion. In addition, the expression of both receptors increased progressively in reactive astrocytes within the vicinity of the lesion, predominately in the white matter, and almost all reactive astrocytes coexpressed Flt-1 or Flk-1 and nestin. These results suggest that VEGF may be involved in the inflammatory response and the astroglial reaction to contusion injuries of the spinal cord via specific VEGF receptors. (J Histochem Cytochem 55: 821–830, 2007)

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