scholarly journals Abnormal resting-state functional connectivity in posterior cingulate cortex of Parkinson's disease with mild cognitive impairment and dementia

2018 ◽  
Vol 24 (10) ◽  
pp. 897-905 ◽  
Author(s):  
Zhou-Wei Zhan ◽  
Li-Zhen Lin ◽  
Er-Han Yu ◽  
Jia-Wei Xin ◽  
Lin Lin ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Resting State Functional Connectivity ◽  
Posterior Cingulate

Resting-state functional connectivity associated with mild cognitive impairment in Parkinson’s disease

2014 ◽  
Vol 262 (2) ◽  
pp. 425-434 ◽  
Author(s):  
Marianna Amboni ◽  
Alessandro Tessitore ◽  
Fabrizio Esposito ◽  
Gabriella Santangelo ◽  
Marina Picillo ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Resting State ◽  
Resting State Functional Connectivity

scholarly journals Neural basis underlying the trait of attachment anxiety and avoidance revealed by the amplitude of low-frequency fluctuations and resting-state functional connectivity

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Min Deng ◽  
Xing Zhang ◽  
Xiaoyan Bi ◽  
Chunhai Gao
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Low Frequency ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Attachment Anxiety ◽  
Frequency Fluctuation ◽  
Resting State Functional Connectivity ◽  
Attachment Avoidance ◽  
Posterior Cingulate

Abstract Background Attachment theory demonstrates that early attachment experience shapes internal working models with mental representations of self and close relationships, which affects personality traits and interpersonal relationships in adulthood. Although research has focused on brain structural and functional underpinnings to disentangle attachment styles in healthy individuals, little is known about the spontaneous brain activity associated with self-reported attachment anxiety and avoidance during the resting state. Methods One hundred and nineteen individuals participated in the study, completing the Experience in Close Relationship scale immediately after an 8-min fMRI scanning. We used the resting-state functional magnetic resonance imaging (rs-fMRI) signal of the amplitude of low-frequency fluctuation and resting-state functional connectivity to identify attachment-related regions and networks. Results Consequently, attachment anxiety is closely associated with the amplitude of low-frequency fluctuations in the right posterior cingulate cortex, over-estimating emotional intensity and exaggerating outcomes. Moreover, the functional connectivity between the posterior cingulate cortex and fusiform gyrus increases detection ability for potential threat or separation information, facilitating behavior motivation. The attachment avoidance is positively correlated with the amplitude of low-frequency fluctuation in the bilateral lingual gyrus and right postcentral and negatively correlated with the bilateral orbital frontal cortex and inferior temporal gyrus. Functional connection with attachment avoidance contains critical nodes in the medial temporal lobe memory system, frontal-parietal network, social cognition, and default mode network necessary to deactivate the attachment system and inhibit attachment-related behavior. Conclusion and implications These findings clarify the amplitude of low-frequency fluctuation and resting-state functional connectivity neural signature of attachment style, associated with attachment strategies in attachment anxiety and attachment avoidance individuals. These findings may improve our understanding of the pathophysiology of the attachment-related disorder.

scholarly journals Altered resting-state functional connectivity in emotion-processing brain regions in adults who were born very preterm

2016 ◽  
Vol 46 (14) ◽  
pp. 3025-3039 ◽  
Author(s):  
C. Papini ◽  
T. P. White ◽  
A. Montagna ◽  
P. J. Brittain ◽  
S. Froudist-Walsh ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Emotion Processing ◽  
Recognition Task ◽  
Cingulate Cortex ◽  
Posterior Cingulate Cortex ◽  
Resting State Functional Connectivity ◽  
Dynamic Stimuli ◽  
Posterior Cingulate ◽  
Very Preterm

BackgroundVery preterm birth (VPT; <32 weeks of gestation) has been associated with impairments in emotion regulation, social competence and communicative skills. However, the neuroanatomical mechanisms underlying such impairments have not been systematically studied. Here we investigated the functional integrity of the amygdala connectivity network in relation to the ability to recognize emotions from facial expressions in VPT adults.MethodThirty-six VPT-born adults and 38 age-matched controls were scanned at rest in a 3-T MRI scanner. Resting-state functional connectivity (rs-fc) was assessed with SPM8. A seed-based analysis focusing on three amygdalar subregions (centro-medial/latero-basal/superficial) was performed. Participants’ ability to recognize emotions was assessed using dynamic stimuli of human faces expressing six emotions at different intensities with the Emotion Recognition Task (ERT).ResultsVPT individuals compared to controls showed reduced rs-fc between the superficial subregion of the left amygdala, and the right posterior cingulate cortex (p = 0.017) and the left precuneus (p = 0.002). The VPT group further showed elevated rs-fc between the left superficial amygdala and the superior temporal sulcus (p = 0.008). Performance on the ERT showed that the VPT group was less able than controls to recognize anger at low levels of intensity. Anger scores were significantly associated with rs-fc between the superficial amygdala and the posterior cingulate cortex in controls but not in VPT individuals.ConclusionsThese findings suggest that alterations in rs-fc between the amygdala, parietal and temporal cortices could represent the mechanism linking VPT birth and deficits in emotion processing.

scholarly journals Functional Connectivity in Parkinson's Disease Patients with Mild Cognitive Impairment

2020 ◽  
Author(s):  
Qingguang Wang ◽  
Wei He ◽  
Dinghua Liu ◽  
Bojun Han ◽  
Qitao Jiang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Connectivity ◽  
Demographic Data ◽  
Posterior Cingulate Cortex ◽  
Mri Scans ◽  
The Relationship ◽  
Normal Cognition

Abstract Background: To explore the alteration of pattens of anatomical and functional connectivity (FC) of posterior cingulate cortex (PCC) in Parkinson's disease (PD) patients with cognitive dysfunction and the relationship between the connection strengths and cognitive state．Methods: We prospectively enrolled 20 PD patients with mild cognitive impairment (PD-MCI), 13 PD patients with normal cognition (PD-NC) and 13 healthy controls (HCs). All subjects underwent clinical evaluations and MRI scans. By collecting, preprocessing and FC analyzing resting-state functional magnetic resonance imaging (rs-fMRI) data, we extracted default mode network (DMN) patterns, compared the differences in DMN between the three groups and the analyzed the correlation between FC value with the commonly used neuropsychological testing.Results: There were not significant differences with regard to demographic data among the three groups. The PD-MCI showed significant worse performances in general cognition, and PD-NC and HCs showed comparable performances of cognitive function. Cognitive-related differences in DMN were detected in the bilateral precuneus (BPcu). Compared with the HCs, PD-NC and PD-MCI showed significantly decreased FC within BPcu (both P < 0.001). For PD-MCI, the rho of the the Fisher’s Z-transformed FC (zFC) value within BPcu with the TMTA, DSST and CFT-20min were − 0.50, 0.66 and 0.47, respectively. For PD-NC, the rho of the zFC value within BPcu with the MMSE was 0.58.Conclusions: Our research found that BPcu was the cognitive related region in DMN. As cognition declines, FC within BPcu weaken. For PD-MCI, the higher the FC values within BPcu were related to the better the performances of TMTA, DSST and CFT-20 min DR. For PD patients with normal cognition, the FC within BPcu were positively correlated with scores of MMSE.

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