scholarly journals A role of Heat Shock Protein 70 in Photoreceptor Cell Death: Potential as a Novel Therapeutic Target in Retinal Degeneration

2015 ◽  
Vol 22 (1) ◽  
pp. 7-14 ◽  
Author(s):  
Ayako Furukawa ◽  
Yoshiki Koriyama
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Retinal Degeneration ◽  
Therapeutic Target ◽  
Heat Shock Protein 70 ◽  
Photoreceptor Cell ◽  
Novel Therapeutic

scholarly journals Role of inducible heat shock protein 70 in radiation-induced cell death

2001 ◽  
Vol 6 (3) ◽  
pp. 273 ◽  
Author(s):  
Su-Jae Lee ◽  
Sun-Ah Choi ◽  
Kang-Hyun Lee ◽  
Hee-Yong Chung ◽  
Tae-Hwan Kim ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Radiation Induced

Thiopental protects human neuroblastoma cells from apoptotic cell death — Potential role of heat shock protein 70

Life Sciences ◽  
2015 ◽  
Vol 139 ◽  
pp. 40-45 ◽  
Author(s):  
Martin Roesslein ◽  
Christian Froehlich ◽  
Verena Miltenberger ◽  
Felix Ulbrich ◽  
Ulrich Goebel ◽  
...  
Keyword(s):  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Potential Role ◽  
Apoptotic Cell ◽  
Neuroblastoma Cells ◽  
Human Neuroblastoma Cells ◽  
Human Neuroblastoma

scholarly journals Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N -methyl-N -nitrosourea in mice

2014 ◽  
Vol 130 (5) ◽  
pp. 707-719 ◽  
Author(s):  
Yoshiki Koriyama ◽  
Kayo Sugitani ◽  
Kazuhiro Ogai ◽  
Satoru Kato
Keyword(s):  
Valproic Acid ◽  
Cell Death ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Photoreceptor Cell

scholarly journals Heat shock protein 70–2 (HSP70-2) is a novel therapeutic target for colorectal cancer and is associated with tumor growth

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Nirmala Jagadish ◽  
Deepak Parashar ◽  
Namita Gupta ◽  
Sumit Agarwal ◽  
Vaishali Suri ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Tumor Growth ◽  
Therapeutic Target ◽  
Heat Shock Protein 70 ◽  
Novel Therapeutic

Protective role of myocardial heat shock protein 70 in burn trauma: Another brick in the wall?

2004 ◽  
Vol 32 (6) ◽  
pp. 1425-1426 ◽  
Author(s):  
Martin Westphal ◽  
Perenlei Enkhbaatar ◽  
Daniel L. Traber
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Protective Role ◽  
Burn Trauma

scholarly journals Redefining the role of Ca2+-permeable channels in photoreceptor degeneration using diltiazem

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Soumyaparna Das ◽  
Valerie Popp ◽  
Michael Power ◽  
Kathrin Groeneveld ◽  
Jie Yan ◽  
...  
Keyword(s):  
Cell Death ◽  
Retinal Degeneration ◽  
Photoreceptor Cell ◽  
Strong Increase ◽  
Channel Blockers ◽  
Photoreceptor Degeneration ◽  
Therapy Development ◽  
Hypertensive Drug ◽  
Future Therapy

AbstractHereditary degeneration of photoreceptors has been linked to over-activation of Ca2+-permeable channels, excessive Ca2+-influx, and downstream activation of Ca2+-dependent calpain-type proteases. Unfortunately, after more than 20 years of pertinent research, unequivocal evidence proving significant and reproducible photoreceptor protection with Ca2+-channel blockers is still lacking. Here, we show that both D- and L-cis enantiomers of the anti-hypertensive drug diltiazem were very effective at blocking photoreceptor Ca2+-influx, most probably by blocking the pore of Ca2+-permeable channels. Yet, unexpectedly, this block neither reduced the activity of calpain-type proteases, nor did it result in photoreceptor protection. Remarkably, application of the L-cis enantiomer of diltiazem even led to a strong increase in photoreceptor cell death. These findings shed doubt on the previously proposed links between Ca2+ and retinal degeneration and are highly relevant for future therapy development as they may serve to refocus research efforts towards alternative, Ca2+-independent degenerative mechanisms.

The Role of Heat Shock Protein 70 in Infection and Immunity

2015 ◽  
pp. 95-117
Author(s):  
Jose Rey-Ladino ◽  
Abiola Senok ◽  
Abdullah Sarkar ◽  
Ahlam Al Shedoukhy
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70
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