17‐β‐Estradiol increases macrophage activity through activation of the G‐protein‐coupled estrogen receptor and improves the response of female mice to Cryptococcus gattii

2020 ◽  
Vol 22 (6) ◽  
Author(s):  
Marliete C. Costa ◽  
Heliana Barros Fernandes ◽  
Gleisy K. N. Gonçalves ◽  
Anderson P. N. Santos ◽  
Gabriella F. Ferreira ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Cryptococcus Gattii ◽  
Female Mice ◽  
Macrophage Activity ◽  
G Protein Coupled

scholarly journals Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice

Neurosignals ◽  
2013 ◽  
Vol 21 (3-4) ◽  
pp. 229-239 ◽  
Author(s):  
Brad R.S. Broughton ◽  
Vanessa H. Brait ◽  
Elizabeth Guida ◽  
Seyoung Lee ◽  
Thiruma V. Arumugam ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Receptor Expression ◽  
Estrogen Receptor Expression ◽  
Female Mice ◽  
G Protein Coupled ◽  
The Brain

scholarly journals Activation of Estrogen Receptor G Protein–Coupled Receptor 30 Enhances Cholesterol Cholelithogenesis in Female Mice

Hepatology ◽  
2020 ◽  
Vol 72 (6) ◽  
pp. 2077-2089 ◽  
Author(s):  
Helen H. Wang ◽  
Ornella Bari ◽  
Christopher K. Arnatt ◽  
Min Liu ◽  
Piero Portincasa ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
G Protein Coupled Receptor ◽  
Female Mice ◽  
G Protein Coupled

Impact of Aging and G Protein‐Coupled Estrogen Receptor Deletion in Arterial Stiffening and Cardiac Function in Male and Female Mice

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Benard Ojwang Ogola ◽  
Margaret A. Zimmerman ◽  
Nicholas R. Harris ◽  
Isabella Kilanowski-Doroh ◽  
Leanne Groban ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cardiac Function ◽  
G Protein ◽  
Male And Female ◽  
Arterial Stiffening ◽  
Female Mice ◽  
G Protein Coupled

scholarly journals G Protein‐Coupled Estrogen Receptor 1 is Required for Greater Endothelin‐1 Excretion in Female Mice

2021 ◽  
Vol 35 (S1) ◽  
Author(s):  
Ginger Guthrie ◽  
Rawan Almutlaq ◽  
Maryam Butt ◽  
David Pollock ◽  
Eman Gohar
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Female Mice ◽  
Endothelin 1 ◽  
G Protein Coupled ◽  
Estrogen Receptor 1

scholarly journals G Protein–Coupled Estrogen Receptor 30 Reduces Transverse Aortic Constriction–Induced Myocardial Fibrosis in Aged Female Mice by Inhibiting the ERK1/2 -MMP-9 Signaling Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaowu Wang ◽  
Jipeng Ma ◽  
Shuaishuai Zhang ◽  
Zilin Li ◽  
Ziwei Hong ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Cardiovascular Diseases ◽  
G Protein ◽  
Myocardial Fibrosis ◽  
Transverse Aortic Constriction ◽  
Aortic Constriction ◽  
Female Mice ◽  
G Protein Coupled ◽  
Tgf Β1

The incidence of cardiovascular diseases was significantly increased in postmenopausal women. The protection of estrogen in the cardiovascular system has been further reported for decades. Although menopausal hormone therapy has been used in many clinical trials, the debatable results indicate that the studies for elucidating the precise molecular mechanism are urgently required. G protein–coupled estrogen receptor 30 (GPR30) is a membrane receptor of estrogen and displays protective roles in diverse cardiovascular diseases. Previous studies have revealed that ERK1/2-mediated MMP-9 signaling was involved in ischemic heart diseases. However, the role of ERK1/2-mediated MMP-9 signaling in the protection of GPR30 against cardiac hypertrophy in aged female mice has not been investigated. Our present study demonstrated that GPR30 overexpression and its agonist G1 co-administration reduced transverse aortic constriction–induced myocardial fibrosis and preserved cardiac function in aged female mice. MMP-9 expression was markedly increased via ERK1/2 phosphorylation in transverse aortic constriction–injured myocardium of aged female mice. Further results showed that GPR30/G1 activation decreased MMP-9 expression via ERK1/2 inhibition, which further reduced TGF-β1 expression. Inhibition of the ERK1/2 signaling pathway by its inhibitor PD98059 suppressed the induction of the cardiomyocyte MMP-9 level caused by the GRP30 antagonist G15 and inhibited TGF-β1 expression in cardiac fibroblast in vitro. In summary, our results from in vivo and in vitro studies indicated that GPR30 activation inhibited myocardial fibrosis and preserved cardiac function via inhibiting ERK-mediated MMP-9 expression. Thus, the present study may provide the novel drug targets for prevention and treatment of cardiac pathological hypertrophy in postmenopausal women.

Rapid effects of dorsal hippocampal G-protein coupled estrogen receptor on learning in female mice

2017 ◽  
Vol 77 ◽  
pp. 131-140 ◽  
Author(s):  
Jennifer Lymer ◽  
Alana Robinson ◽  
Boyer D. Winters ◽  
Elena Choleris
Keyword(s):  
Estrogen Receptor ◽  
G Protein ◽  
Female Mice ◽  
Dorsal Hippocampal ◽  
G Protein Coupled
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