scholarly journals The endoplasmic reticulum chaperone PfGRP170 is essential for asexual development and is linked to stress response in malaria parasites

2019 ◽  
Vol 21 (9) ◽  
Author(s):  
Heather M. Kudyba ◽  
David W. Cobb ◽  
Manuel A. Fierro ◽  
Anat Florentin ◽  
Dragan Ljolje ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Stress Response ◽  
Asexual Development ◽  
Malaria Parasites ◽  
Endoplasmic Reticulum Chaperone

scholarly journals Activation of endoplasmic reticulum stress response during the development of ischemic heart disease

2006 ◽  
Vol 291 (3) ◽  
pp. H1411-H1420 ◽  
Author(s):  
Asim Azfer ◽  
Jianli Niu ◽  
Linda M. Rogers ◽  
Frances M. Adamski ◽  
Pappachan E. Kolattukudy
Keyword(s):  
Endoplasmic Reticulum ◽  
Heart Disease ◽  
Stress Response ◽  
Transgenic Mice ◽  
Ischemic Heart Disease ◽  
Er Stress ◽  
Stress Proteins ◽  
Gene Array ◽  
Ischemic Heart ◽  
Endoplasmic Reticulum Stress Response

Endoplasmic reticulum (ER) stress has been found to be associated with neurodegenerative diseases and diabetes mellitus. Whether ER stress is involved in the development of heart disease is not known. Cardiac-specific expression of monocyte chemoattractant protein-1 (MCP-1) in mice causes the development of ischemic heart disease. Here we report that microarray analysis of gene expression changes in the heart of these transgenic mice revealed that a cluster of ER stress-related genes was transcriptionally activated in the heart during the development of ischemic heart disease. The gene array results were verified by quantitative real-time PCR that showed highly elevated transcript levels of genes involved in unfolded protein response such as ER and cytoplasmic chaperones, oxidoreductases, protein disulfide isomerase (PDI) family, and ER-associated degradation system such as ubiquitin. Immunoblot analysis confirmed the expression of chaperones, PDI, and ubiquitin. Immunohistochemical analyses showed that ER stress proteins were associated mainly with the degenerating cardiomyocytes. A novel ubiquitin fold modifier (Ufm1) that has not been previously associated with ER stress and not found to be induced under any condition was also found to be upregulated in the hearts of MCP mice (transgenic mice that express MCP-1 specifically in the heart). The present results strongly suggest that activation of ER stress response is involved in the development of ischemic heart disease in this murine model.

scholarly journals Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction

2016 ◽  
Vol 118 (5) ◽  
pp. 798-809 ◽  
Author(s):  
Hai Ying Fu ◽  
Shoji Sanada ◽  
Takashi Matsuzaki ◽  
Yulin Liao ◽  
Keiji Okuda ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Cardiac Dysfunction ◽  
Endoplasmic Reticulum Chaperone
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