scholarly journals Leucocyte recruitment and molecular fortification of keratinocytes triggered by streptococcal M1 protein

2017 ◽  
Vol 20 (1) ◽  
pp. e12792 ◽  
Author(s):  
Sandra T. Persson ◽  
Simon Hauri ◽  
Johan Malmström ◽  
Heiko Herwald
Keyword(s):  
M1 Protein ◽  
Leucocyte Recruitment

scholarly journals The Role of P-Selectin in COVID-19 Coagulopathy: An Updated Review

2021 ◽  
Vol 22 (15) ◽  
pp. 7942
Author(s):  
Chiara Agrati ◽  
Alessandra Sacchi ◽  
Eleonora Tartaglia ◽  
Alessandra Vergori ◽  
Roberta Gagliardini ◽  
...  
Keyword(s):  
Endothelial Activation ◽  
Cardiovascular Complications ◽  
Current State ◽  
Activated Platelets ◽  
Blood Clots ◽  
Severe Infections ◽  
Platelet Aggregates ◽  
Definition Of ◽  
Leucocyte Recruitment

In severe COVID-19, which is characterized by blood clots and neutrophil-platelet aggregates in the circulating blood and different tissues, an increased incidence of cardiovascular complications and venous thrombotic events has been reported. The inflammatory storm that characterizes severe infections may act as a driver capable of profoundly disrupting the complex interplay between platelets, endothelium, and leukocytes, thus contributing to the definition of COVID-19-associated coagulopathy. In this frame, P-selectin represents a key molecule expressed on endothelial cells and on activated platelets, and contributes to endothelial activation, leucocyte recruitment, rolling, and tissue migration. Briefly, we describe the current state of knowledge about P-selectin involvement in COVID-19 pathogenesis, its possible use as a severity marker and as a target for host-directed therapeutic intervention.

scholarly journals Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication

2009 ◽  
Vol 11 (5) ◽  
pp. 730-741 ◽  
Author(s):  
Xiaoling Liu ◽  
Lei Sun ◽  
Maorong Yu ◽  
Zengfu Wang ◽  
Chongfeng Xu ◽  
...  
Keyword(s):  
Viral Replication ◽  
Influenza A Virus ◽  
Influenza A ◽  
Early Stage ◽  
Cyclophilin A ◽  
M1 Protein

scholarly journals Targeting Rac1 Signaling Inhibits Streptococcal M1 Protein-Induced CXC Chemokine Formation, Neutrophil Infiltration and Lung Injury

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e71080 ◽  
Author(s):  
Songen Zhang ◽  
Milladur Rahman ◽  
Su Zhang ◽  
Lei Song ◽  
Heiko Herwald ◽  
...  
Keyword(s):  
Lung Injury ◽  
Neutrophil Infiltration ◽  
M1 Protein ◽  
Cxc Chemokine

scholarly journals Complement Activation Occurs at the Surface of Platelets Activated by Streptococcal M1 Protein and This Results in Phagocytosis of Platelets

2018 ◽  
Vol 202 (2) ◽  
pp. 503-513 ◽  
Author(s):  
Frida Palm ◽  
Kristoffer Sjöholm ◽  
Johan Malmström ◽  
Oonagh Shannon
Keyword(s):  
Complement Activation ◽  
M1 Protein

GLAXO/MRS PAPERRoles of chemokines in the regulation of leucocyte recruitment*

2001 ◽  
Vol 100 (4) ◽  
pp. 359-362
Author(s):  
Ian SABROE ◽  
Timothy J. WILLIAMS ◽  
James E. PEASE
Keyword(s):  
Small Molecules ◽  
Inflammatory Disease ◽  
Chemokine Receptors ◽  
Allergic Inflammation ◽  
New Treatments ◽  
Leucocyte Recruitment

In the search for new treatments for human inflammatory disease, antagonism of chemokine receptors by small molecules is an attractive goal. Although there are overlapping patterns of expression of chemokine receptors between leucocyte types, an investigation of the chemokine responsiveness of cells important in allergic inflammation, such as the eosinophil and the basophil, is beginning to uncover how selective recruitment may be regulated. The story of the eotaxin receptor, CCR3, and its central role in allergic inflammation illustrates that therapeutic antagonism of these pathways is imminently achievable.

Matrix proteins of enveloped viruses: a case study of Influenza A virus M1 protein

2018 ◽  
Vol 37 (3) ◽  
pp. 671-690 ◽  
Author(s):  
Larisa V. Kordyukova ◽  
Eleonora V. Shtykova ◽  
Lyudmila A. Baratova ◽  
Dmitri I. Svergun ◽  
Oleg V. Batishchev
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Matrix Proteins ◽  
Enveloped Viruses ◽  
M1 Protein

Annexin 1 and neutrophil apoptosis

2004 ◽  
Vol 32 (3) ◽  
pp. 507-510 ◽  
Author(s):  
M. Perretti ◽  
E. Solito
Keyword(s):  
Inflammatory Response ◽  
Binding Proteins ◽  
Neutrophil Apoptosis ◽  
The Novel ◽  
Inhibitory Effects ◽  
Phospholipid Binding ◽  
Annexin 1 ◽  
Anti Inflammatory ◽  
Leucocyte Recruitment ◽  
Host Inflammatory Response

ANXA1 (annexin 1), a member of the ‘annexin’ family of calcium- and phospholipid-binding proteins, was originally identified as an endogenous mediator of the anti-inflammatory actions of glucocorticoids. However, this protein exerts multiple inhibitory effects on the host inflammatory response, including a preferential regulation of the adhesion step of blood-borne neutrophil within the microenvironment of an inflamed vasculature. It is now emerging that ANXA1 is endowed with other roles, since the protein is abundant in inflammatory exudates as it is produced and released by the extravasated neutrophil. In the present paper, we review the novel proapoptotic effect of ANXA1 and discuss its potential with respect to the pathophysiology of inflammation and leucocyte recruitment.

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