Influence of hydroxyapatite granule size, porosity, and crystallinity on tissue reactionin vivo. Part B: a comparative study with biphasic synthetic biomaterials

2016 ◽  
Vol 29 (11) ◽  
pp. 1077-1084 ◽  
Author(s):  
José Eduardo Maté Sánchez de Val ◽  
José Luis Calvo-Guirado ◽  
Gerardo Gómez-Moreno ◽  
Sergio Gehrke ◽  
Patricia Mazón ◽  
...  
2015 ◽  
Vol 27 (11) ◽  
pp. 1331-1338 ◽  
Author(s):  
José E. Maté Sánchez de Val ◽  
José L. Calvo-Guirado ◽  
Gerardo Gómez-Moreno ◽  
Carlos Pérez-Albacete Martínez ◽  
Patricia Mazón ◽  
...  

Author(s):  
Igor Zupanets ◽  
Sergey Shebeko ◽  
Stanislav Zimin

Objective: The objective of the study was to compare the degree of micronization of the bioflavonoid fraction (90% diosmin and 10% hesperidin) of different manufacturers which used for the treatment of the chronic venous insufficiency.Methods: “Detralex®,” medicines N and D, 500 mg coated tablets each were used as studied objects. Microscopy of the tablets matrix of the investigational drugs was performed after spontaneous decomposition in a water solution at pH=6.8, using a modular light field microscope of the research class B-1000BF (Optika, Italy) with a digital camera Optikam HDMI Pro (Optika, Italy) with measuring of the size of the flavonoid fraction granules.Results : About 92.8% of the granules of the “Detralex®” tablets matrix were presented by the smallest size of the granules (1–5 μ), unlike D and N, in which 12.9% and 10% of the same size granules were observed. Giant granule size (up to 50 μm) was discovered in D and N tablets matrix and no such granules size were found in the “Detralex®” tablets matrix.Conclusion: Different degrees of micronization of the purified flavonoid fraction in the studied test samples indicate that the drugs D and N are not pharmaceutically equivalent to the original “Detralex®” drug and cannot be considered as copies without further research.


2020 ◽  
Author(s):  
Bruno Oliveira Ferreira de Souza ◽  
Éve‐Marie Frigon ◽  
Robert Tremblay‐Laliberté ◽  
Christian Casanova ◽  
Denis Boire

2001 ◽  
Vol 268 (6) ◽  
pp. 1739-1748
Author(s):  
Aitor Hierro ◽  
Jesus M. Arizmendi ◽  
Javier De Las Rivas ◽  
M. Angeles Urbaneja ◽  
Adelina Prado ◽  
...  

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