Long-term outcomes after vestibuloplasty with a porcine collagen matrix (Mucograft® ) versus the free gingival graft: a comparative prospective clinical trial

2015 ◽  
Vol 27 (11) ◽  
pp. e125-e133 ◽  
Author(s):  
Christian M. Schmitt ◽  
Tobias Moest ◽  
Rainer Lutz ◽  
Falk Wehrhan ◽  
Friedrich W. Neukam ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Collagen Matrix ◽  
Prospective Clinical Trial ◽  
Long Term Outcomes ◽  
Free Gingival Graft ◽  
Gingival Graft ◽  
Porcine Collagen

scholarly journals Use of Mucograft Collagen Matrix® versus Free Gingival Graft to Augment Keratinized Tissue Around Teeth: A Randomized Controlled Clinical Trial

2020 ◽  
Author(s):  
Amirreza Rokn ◽  
Hadi Zare ◽  
Pardis Haddadi
Keyword(s):  
Clinical Trial ◽  
Dimensional Change ◽  
Collagen Matrix ◽  
Controlled Clinical Trial ◽  
Randomized Controlled Clinical Trial ◽  
Double Blind ◽  
Free Gingival Graft ◽  
Randomized Controlled ◽  
Keratinized Tissue ◽  
Gingival Graft

Objectives: This study aimed to evaluate the mucograft collagen matrix (CM) to increase keratinized tissue around teeth compared to free gingival graft (FGG). Materials and Methods: The present double-blind, randomized, controlled clinical trial studied 12 patients who had 2 mm or less keratinized gingiva bilaterally around mandibular premolars. The 6-month width of keratinized tissue, periodontal parameters (preoperatively and 1, 3, and 6 months postoperatively), color match, pain, and total surgical time were measured. Results: The mean dimensional change of keratinized gingiva 6 months postoperatively was 4.1±0.7 mm for FGG and 8±1.7 mm for CM. Periodontal parameters were not affected in the two groups. The CM group had a significantly lower pain, experienced less surgery time, and gained better aesthetics compared to the FGG group. Conclusion: CM appears to be a suitable substitute for FGG in procedures designed to increase keratinized tissue around teeth. It has remarkable benefits, such as acceptable keratinized tissue gain, less pain, less surgical chair time, and better aesthetics.

scholarly journals The Effect of Three Surgical Therapies to Increase Keratinized Mucosa Surrounding Dental Implants with Peri-Implantitis: A Pilot Study

Medicina ◽  
2021 ◽  
Vol 57 (10) ◽  
pp. 1093
Author(s):  
In-Kyung Lee ◽  
Hyun-Seok Choi ◽  
Sang-Heon Jeong ◽  
Jung-Tae Lee
Keyword(s):  
Pilot Study ◽  
Dental Implants ◽  
Collagen Matrix ◽  
Pocket Depth ◽  
Free Gingival Graft ◽  
Probing Pocket Depth ◽  
Significant Difference ◽  
Keratinized Mucosa ◽  
Gingival Graft ◽  
Porcine Collagen

Background and Objectives: The purpose of this pilot study was to evaluate the clinical outcomes of three different methods for increasing the keratinized mucosa (KM) surrounding dental implants with peri-implantitis. Materials and methods: Twenty implant sites with peri-implantitis were divided into: (1) porcine collagen matrix (CM) group: seven implant sites; (2) apically positioned flap (APF) group: eight implant sites; and (3) free gingival graft (FGG) group: five implant sites. The KM width and clinical parameters (probing pocket depth (PPD) and bleeding on probing (BOP)) were measured at time points: before surgery (T0) and 30 (T1), 60 (T2), 90 (T3), and 180 (T4) days after surgery. Results: Regarding KM width, all the groups had significant differences for increasing horizontal and vertical KM width. The CM and FGG groups had greater KM than the APF group. There was a decrease in PPD in all three groups. APF and FGG showed significant differences in PPD at T1 and T2 compared to T0. Only the FGG group showed a significant difference in PPD at T3 and T4 compared with that at T0. BOP values were also reduced in all the groups at T1–T4 compared to T0. The APF and FGG groups showed a significant decrease in BOP. Conclusions: Three surgical therapies presented favorable results for increasing the KM surrounding implants. Compared with the FGG group, the CM showed similar results in increasing the KM around the dental implants with peri-implantitis.

Vestibuloplasty: Porcine Collagen Matrix Versus Free Gingival Graft: A Clinical and Histologic Study

2013 ◽  
Vol 84 (7) ◽  
pp. 914-923 ◽  
Author(s):  
Christian M. Schmitt ◽  
Christian Tudor ◽  
Katrin Kiener ◽  
Falk Wehrhan ◽  
Johannes Schmitt ◽  
...  
Keyword(s):  
Collagen Matrix ◽  
Matrix Versus ◽  
Histologic Study ◽  
Free Gingival Graft ◽  
Gingival Graft ◽  
Porcine Collagen

Free Gingival Graft and Collagen Matrix Revascularization in an Enoral Open Wound Situation

2021 ◽  
Author(s):  
Raimund H.M. Preidl ◽  
Sky Reichert ◽  
Talisa V. Coronel ◽  
Marco Kesting ◽  
Falk Wehrhan ◽  
...  
Keyword(s):  
Collagen Matrix ◽  
Open Wound ◽  
Free Gingival Graft ◽  
Gingival Graft

scholarly journals Combined low-dose everolimus and low-dose tacrolimus after Alemtuzumab induction therapy: a randomized prospective trial in lung transplantation

Trials ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Alberto Benazzo ◽  
Ara Cho ◽  
Anna Nechay ◽  
Stefan Schwarz ◽  
Florian Frommlet ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Lung Transplantation ◽  
Kidney Function ◽  
Induction Therapy ◽  
Low Dose ◽  
Prospective Trial ◽  
Control Group ◽  
Long Term Outcomes ◽  
Maintenance Immunosuppression

Abstract Background Long-term outcomes of lung transplantation are severely affected by comorbidities and development of chronic rejection. Among the comorbidities, kidney insufficiency is one of the most frequent and it is mainly caused by the cumulative effect of calcineurin inhibitors (CNIs). Currently, the most used immunosuppression protocols worldwide include induction therapy and a triple-drug maintenance immunosuppression, with one calcineurin inhibitor, one anti-proliferative drug, and steroids. Our center has pioneered the use of alemtuzumab as induction therapy, showing promising results in terms of short- and long-term outcomes. The use of alemtuzumab followed by a low-dose double drug maintenance immunosuppression, in fact, led to better kidney function along with excellent results in terms of acute rejection, chronic lung allograft dysfunction, and survival (Benazzo et al., PLoS One 14(1):e0210443, 2019). The hypothesis driving the proposed clinical trial is that de novo introduction of low-dose everolimus early after transplantation could further improve kidney function via a further reduction of tacrolimus. Based on evidences from kidney transplantation, moreover, alemtuzumab induction therapy followed by a low-dose everolimus and low-dose tacrolimus may have a permissive action on regulatory immune cells thus stimulating allograft acceptance. Methods A randomized prospective clinical trial has been set up to answer the research hypothesis. One hundred ten patients will be randomized in two groups. Treatment group will receive the new maintenance immunosuppression protocol based on low-dose tacrolimus and low-dose everolimus and the control group will receive our standard immunosuppression protocol. Both groups will receive alemtuzumab induction therapy. The primary endpoint of the study is to analyze the effect of the new low-dose immunosuppression protocol on kidney function in terms of eGFR change. The study will have a duration of 24 months from the time of randomization. Immunomodulatory status of the patients will be assessed with flow cytometry and gene expression analysis. Discussion For the first time in the field of lung transplantation, this trial proposes the combined use of significantly reduced tacrolimus and everolimus after alemtuzumab induction. The new protocol may have a twofold advantage: (1) further reduction of nephrotoxic tacrolimus and (2) permissive influence on regulatory cells development with further reduction of rejection episodes. Trial registration EUDRACT Nr 2018-001680-24. Registered on 15 May 2018

scholarly journals Long-term response to renal ischaemia in the human kidney after partial nephrectomy: results from a prospective clinical trial

2015 ◽  
Vol 117 (5) ◽  
pp. 766-774 ◽  
Author(s):  
George J.S. Kallingal ◽  
Joel M. Weinberg ◽  
Isildinha M. Reis ◽  
Avinash Nehra ◽  
Manjeri A. Venkatachalam ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Partial Nephrectomy ◽  
Human Kidney ◽  
Prospective Clinical Trial ◽  
Renal Ischaemia ◽  
Term Response
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