Influence of osteoporosis on the osteocyte density of human mandibular bone samples: a controlled histological human study

2014 ◽  
Vol 27 (3) ◽  
pp. 325-328 ◽  
Author(s):  
Pablo S. Oliveira ◽  
José A. Rodrigues ◽  
Jamil A. Shibli ◽  
Adriano Piattelli ◽  
Giovanna Iezzi ◽  
...  
Keyword(s):  
Human Study ◽  
Mandibular Bone ◽  
Osteocyte Density

Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone

2009 ◽  
Vol 88 (7) ◽  
pp. 615-620 ◽  
Author(s):  
S.C.F. Rawlinson ◽  
A. Boyde ◽  
G.R. Davis ◽  
P.G.T. Howell ◽  
F.J. Hughes ◽  
...  
Keyword(s):  
Light Microscopy ◽  
Mechanical Loading ◽  
Alveolar Bone ◽  
Scattered Electron ◽  
Mandibular Bone ◽  
Hormone Levels ◽  
Maxillary Molars ◽  
Old Rats ◽  
Micro Tomography ◽  
Osteocyte Density

Previous studies have suggested that the mandible may be more influenced by mechanical loading than by circulating hormone levels. We tested the hypothesis that hypofunction has a greater influence than ovariectomy on mandibular bone. Two-month-old rats were ovariectomized (OVX) or had maxillary molars removed from one side to induce unilateral mandibular hypofunction. Control animals remained untreated. After 5 months, animals were killed, and bones were assessed by micro-tomography (μCT), quantitative back-scattered electron analysis in an SEM (qBSE-SEM), and light microscopy. Mineralization density was reduced in calvarial, maxillary, and mandibular alveolar bone following OVX, yet was increased in lingual mandibular alveolar bone of the hypo-function animals compared with controls. OVX caused a reduction in osteocyte density in alveolar bone, while hypofunction showed an increase compared with controls. Hypofunction led to alveolar bone becoming more highly mineralized and more cellular, while ovariectomy caused a reduction in both mineralization density and osteocyte numbers.

Investigations on skeletal growth zones via bone scans as base of determination of optimal time for surgery in mandibular asymmetry

2000 ◽  
Vol 39 (05) ◽  
pp. 121-126 ◽  
Author(s):  
R. Werz ◽  
P. Reuland
Keyword(s):  
Bone Growth ◽  
Region Of Interest ◽  
Tracer Uptake ◽  
Optimal Time ◽  
Mandibular Bone ◽  
The Third ◽  
Mandibular Asymmetry ◽  
Bone Scans ◽  
Epiphyseal Plates

Summary Aim of the study was to find out wether there is a common stop of growth of mandibular bone, so that no individual determination of the optimal time for surgery in patients with asymmetric mandibular bone growth is needed. As there are no epiphyseal plates in the mandibular bone, stop of growth cannot be determined on X-ray films. Methods: Bone scans of 731 patients [687 patients (324 male, 363 female) under 39 y for exact determination of end of growth and 44 (21 male, 23 female) patients over 40 y for evaluation of nongrowth dependant differences in tracer uptake] were reviewed for the study. All the patients were examined 3 hours after injection of 99mTc-DPD. Tracer uptake was measured by region of interest technique in different points of the mandibular bone and in several epiphyseal plates of extremities. Results: Tracer uptake in different epiphyseal plates of the extremities shows strong variation with age and good correlation with reported data of bone growth and closure of the epiphyseal plates. The relative maximum of bone activity is smaller in mandibular bone than in epiphyseal plates, which show well defined peaks, ending at 15-18 years in females and at 18-21 years in males. In contrast, mandibular bone shows no well defined end of growing but a gradually reduction of bone activity which remains higher than bone activity in epiphyseal plates over several years. Conclusion: No well defined end of growth of mandibular bone exists. The optimal age for surgery of asymmetric mandibular bone growth is not before the middle of the third decade of life, bone scans performed earlier for determination of bone growth can be omitted. Bone scans performed at the middle of the third decade of life help to optimize the time of surgical intervention.

138-LB: First-in-Human Study of YG1699, an SGLT1 and SGLT2 Dual Transporter Inhibitor

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 138-LB
Author(s):  
CHENGHAI LI ◽  
TONG LI ◽  
FRANK LEE ◽  
ROGER H. XU ◽  
HELEN WANG
Keyword(s):  
Human Study
Sign in / Sign up

Export Citation Format

Share Document