Use of transforming growth factor‐β loaded onto β‐tricalcium phosphate scaffold in a bone regeneration rat calvaria model

2019 ◽  
Author(s):  
Rina Elimelech ◽  
Nizar Khoury ◽  
Tal Tamari ◽  
Israel Blumenfeld ◽  
Zvi Gutmacher ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Regeneration ◽  
Tricalcium Phosphate ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Rat Calvaria

Effect of transforming growth factor-β on rat calvaria

Bone ◽  
1992 ◽  
Vol 13 (5) ◽  
pp. A11-A11
Author(s):  
R. Fujimoto ◽  
H.E. Takahashi ◽  
T. Tanizawa ◽  
N. Yamamoto ◽  
K. Tokunaga
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Rat Calvaria

scholarly journals A boomy century of periodontal regeneration with biological mediators

2021 ◽  
Vol 7 (3) ◽  
pp. 103-117
Author(s):  
Deepak Grover ◽  
Navneet Kaur ◽  
Gurpreet Kaur
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Transforming Growth Factor ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Periodontal Regeneration ◽  
Transforming Growth Factor Β ◽  
Tissue Repair And Regeneration ◽  
Plasma Fraction

With the advanced and improved knowledge of bone regeneration on the molecular level, some of key molecules that alter the complicated physiological method were identified, and are already in scientific use or beneath research to enhance bone restore. Of those molecules, BMPs were the maximum considerably studied, as they are robust osteoinductive elements. They result in the mitogenesis of mesenchymal stem cells (MSCs) and different osteoprogenitors, and their differentiation in the direction of osteoblasts. Other growth factors except BMPs which have been implicated through out the bone regeneration, with one-of-a-kind features with respect of cell proliferation, chemotaxis and angiogenesis, are also being investigated or are presently getting used to reinforce bone restore, which include platelet-derived growth factor, transforming growth factor- β, insulin-like growth factor-1, vascular endothelial growth factor and fibroblast growth factor, amongst others. One present day technique to enhance bone regeneration and soft-tissue recovery with the aid of using nearby application of growth factors is the use of platelet-rich plasma, an extent of the plasma fraction of autologous blood with platelet concentrations above baseline, that is wealthy in most of the aforementioned molecules. This overview focuses and target on the biological mediators that regulates key cellular events which have a capacity to induce the method of tissue repair and regeneration.

Local effects of transforming growth factor-β 1 on rat calvaria: Changes depending on the dose and the injection site

1999 ◽  
Vol 17 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Ryuhei Fujimoto ◽  
Tatsuhiko Tanizawa ◽  
Saburo Nishida ◽  
Noriaki Yamamoto ◽  
Shigeru Soshi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Injection Site ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Local Effects ◽  
Rat Calvaria

Perianale Fisteln bei CED: vom Mausmodell zur Klinik

2018 ◽  
Vol 75 (5) ◽  
pp. 287-294
Author(s):  
Michael Scharl
Keyword(s):  
Growth Factor ◽  
Morbus Crohn ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Interleukin 13

Zusammenfassung. Fisteln stellen nach wie vor eine der wichtigsten Komplikationen bei Patienten mit Morbus Crohn dar. Bei mindestens einem Drittel aller Morbus Crohn Patienten treten im Laufe der Erkrankung Fisteln auf. Eine dauerhafte Heilung der Fistel wird jedoch, auch unter Ausschöpfung sämtlicher medikamentöser und chirurgischer Therapieoptionen, nur in rund einem Drittel dieser Patienten erreicht. Der genaue molekulare Mechanismus der Fistelentstehung ist bis heute nicht ganz klar. Aus histopathologischer Sichtweise stellen Fisteln eine röhrenartige Struktur dar, welche von flachen epithelartigen Zellen ausgekleidet ist. Als ursächlicher Entstehungsmechanismus wird dabei die sogenannte epitheliale-zu-mesenchymale Transition (EMT) angesehen und es kann eine starke Expression der Entzündungsmediatoren Tumor Nekrose Faktor, Interleukin-13 und Transforming Growth Factor β in den Fistelarealen nachgewiesen werden. Zusätzlich zu den bereits etablierten, medikamentösen Therapieoptionen, also Antibiotika, Immunmodulatoren und anti-TNF Antikörper, stellt insbesondere der Einsatz der mesenchymalen Stammzelltherapie einen erfolgversprechenden Therapieansatz für die Zukunft dar.

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