In Vivo Evaluation of a Novel Implant Coating Agent: Laminin-1

2013 ◽  
Vol 16 (5) ◽  
pp. 728-735 ◽  
Author(s):  
Kostas Bougas ◽  
Ryo Jimbo ◽  
Stefan Vandeweghe ◽  
Nick Tovar ◽  
Marta Baldassarri ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Coating Agent ◽  
Implant Coating ◽  
Laminin 1

In vivo evaluation of pH and time-dependent polymers as coating agent for colonic delivery using central composite design

2018 ◽  
Vol 43 ◽  
pp. 50-56 ◽  
Author(s):  
Eskandar Moghimipour ◽  
Farid Abedin Dorkoosh ◽  
Mohsen Rezaei ◽  
Maryam Kouchak ◽  
Jafar Fatahiasl ◽  
...  
Keyword(s):  
Central Composite Design ◽  
Time Dependent ◽  
Colonic Delivery ◽  
In Vivo Evaluation ◽  
Coating Agent ◽  
Central Composite

scholarly journals Novel Implant Coating Agent Promotes Gene Expression of Osteogenic Markers in Rats during Early Osseointegration

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Kostas Bougas ◽  
Ryo Jimbo ◽  
Ying Xue ◽  
Kamal Mustafa ◽  
Ann Wennerberg
Keyword(s):  
Gene Expression ◽  
Cathepsin K ◽  
Titanium Implants ◽  
Type I ◽  
Inflammation Markers ◽  
Coating Agent ◽  
Bone Implant ◽  
Osteogenic Markers ◽  
Implant Coating ◽  
Laminin 1

The aim of this study was to evaluate the early bone response around laminin-1-coated titanium implants. Forty-five rats distributed in three equally sized groups were provided with one control (turned) and one test (laminin-1-coated) implant and were sacrificed after 3, 7, and 21 days. Real-time reverse-transcriptase polymerase chain reaction was performed for osteoblast markers (alkaline phosphatase, runt-related transcription factor 2, osteocalcin, type I collagen, and bone morphogenic protein 2), osteoclast markers (cathepsin K and tartrate-resistant acid phosphatase), inflammation markers (tumor necrosis factorα, interleukin 1βand interleukin 10), and integrinβ1. Bone implant contact (BIC) and bone area (BA) were assessed and compared to the gene expression. After 3 days, the expression of bone markers was higher for the control group. After 7 days, the expression of integrinβ1 and osteogenic markers was enhanced for the test group, while cathepsin K and inflammation markers were down-regulated. No significant differences in BIC or BA were detected between test and control at any time point. As a conclusion, implant coating with laminin-1 altered gene expression in the bone-implant interface. However, traditional evaluation methods, as histomorphometry, were not adequately sensitive to detect such changes due to the short follow-up time.

Radiolabelling and in vivo evaluation of [11C]GSK215083 as potential PET radioligand for the 5-HT6 receptor in the porcine brain

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S598-S598 ◽  
Author(s):  
Laurent Martarello ◽  
Vincent J Cunningham ◽  
Julian C Matthews ◽  
Eugenii Rabiner ◽  
Steen Jakobsen ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Porcine Brain

In vivo evaluation of [11C]CNS-5161 as a use-dependent ligand for the NMDA glutamate receptor channel

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S595-S595 ◽  
Author(s):  
Wynne K Schiffer ◽  
Deborah Pareto-Onghena ◽  
HaiTao Wu ◽  
Kuo-Shyan Lin ◽  
Andrew R Gibbs ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
In Vivo Evaluation ◽  
Nmda Glutamate Receptor ◽  
Receptor Channel

In vitro and in vivo evaluation of the anti-inflammatory effects of Arzanol from Helichrysum italicum

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
J Bauer ◽  
F Dehm ◽  
A Koeberle ◽  
F Pollastro ◽  
G Appendino ◽  
...  
Keyword(s):  
In Vivo Evaluation ◽  
Anti Inflammatory

The supraannular concept – in-vivo evaluation of 5 aortic bioprostheses

2008 ◽  
Vol 56 (S 1) ◽  
Author(s):  
D Ruzicka ◽  
W Eichinger ◽  
I Hettich ◽  
S Bleiziffer ◽  
R Guenzinger ◽  
...  
Keyword(s):  
In Vivo Evaluation
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