scholarly journals A Modified Double Gyre with Ground Truth Hyperbolic Trajectories for Flow Visualization

2020 ◽  
Author(s):  
S. Wolligandt ◽  
T. Wilde ◽  
C. Rössl ◽  
H. Theisel
Keyword(s):  
Flow Visualization ◽  
Ground Truth ◽  
Hyperbolic Trajectories ◽  
Double Gyre

A Comparison of Simple Structure Rotation Criteria in Temporal Exploratory Factor Analysis for Event-Related Potential Data

Methodology ◽  
2019 ◽  
Vol 15 (Supplement 1) ◽  
pp. 43-60 ◽  
Author(s):  
Florian Scharf ◽  
Steffen Nestler
Keyword(s):  
Factor Analysis ◽  
Exploratory Factor Analysis ◽  
Simple Structure ◽  
Ground Truth ◽  
Event Related Potential ◽  
Suitable Alternative ◽  
Factor Rotation ◽  
Rotation Methods ◽  
Simple Structure Rotation ◽  
Temporal Overlap

Abstract. It is challenging to apply exploratory factor analysis (EFA) to event-related potential (ERP) data because such data are characterized by substantial temporal overlap (i.e., large cross-loadings) between the factors, and, because researchers are typically interested in the results of subsequent analyses (e.g., experimental condition effects on the level of the factor scores). In this context, relatively small deviations in the estimated factor solution from the unknown ground truth may result in substantially biased estimates of condition effects (rotation bias). Thus, in order to apply EFA to ERP data researchers need rotation methods that are able to both recover perfect simple structure where it exists and to tolerate substantial cross-loadings between the factors where appropriate. We had two aims in the present paper. First, to extend previous research, we wanted to better understand the behavior of the rotation bias for typical ERP data. To this end, we compared the performance of a variety of factor rotation methods under conditions of varying amounts of temporal overlap between the factors. Second, we wanted to investigate whether the recently proposed component loss rotation is better able to decrease the bias than traditional simple structure rotation. The results showed that no single rotation method was generally superior across all conditions. Component loss rotation showed the best all-round performance across the investigated conditions. We conclude that Component loss rotation is a suitable alternative to simple structure rotation. We discuss this result in the light of recently proposed sparse factor analysis approaches.

Brain FDG PET for the Etiological Diagnosis of Clinically Uncertain Cognitive Impairment During Delirium in Remission

2020 ◽  
Vol 77 (4) ◽  
pp. 1609-1622
Author(s):  
Franziska Mathies ◽  
Catharina Lange ◽  
Anja Mäurer ◽  
Ivayla Apostolova ◽  
Susanne Klutmann ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Fdg Pet ◽  
False Negative ◽  
Ground Truth ◽  
Etiological Diagnosis ◽  
Geriatric Unit ◽  
Positron Emission ◽  
The Brain ◽  
Hospitalized Geriatric Patients

Background: Positron emission tomography (PET) of the brain with 2-[F-18]-fluoro-2-deoxy-D-glucose (FDG) is widely used for the etiological diagnosis of clinically uncertain cognitive impairment (CUCI). Acute full-blown delirium can cause reversible alterations of FDG uptake that mimic neurodegenerative disease. Objective: This study tested whether delirium in remission affects the performance of FDG PET for differentiation between neurodegenerative and non-neurodegenerative etiology of CUCI. Methods: The study included 88 patients (82.0±5.7 y) with newly detected CUCI during hospitalization in a geriatric unit. Twenty-seven (31%) of the patients were diagnosed with delirium during their current hospital stay, which, however, at time of enrollment was in remission so that delirium was not considered the primary cause of the CUCI. Cases were categorized as neurodegenerative or non-neurodegenerative etiology based on visual inspection of FDG PET. The diagnosis at clinical follow-up after ≥12 months served as ground truth to evaluate the diagnostic performance of FDG PET. Results: FDG PET was categorized as neurodegenerative in 51 (58%) of the patients. Follow-up after 16±3 months was obtained in 68 (77%) of the patients. The clinical follow-up diagnosis confirmed the FDG PET-based categorization in 60 patients (88%, 4 false negative and 4 false positive cases with respect to detection of neurodegeneration). The fraction of correct PET-based categorization did not differ between patients with delirium in remission and patients without delirium (86% versus 89%, p = 0.666). Conclusion: Brain FDG PET is useful for the etiological diagnosis of CUCI in hospitalized geriatric patients, as well as in patients with delirium in remission.

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