scholarly journals Structured Regularization of Functional Map Computations

2019 ◽  
Vol 38 (5) ◽  
pp. 39-53 ◽  
Author(s):  
Jing Ren ◽  
Mikhail Panine ◽  
Peter Wonka ◽  
Maks Ovsjanikov
Keyword(s):  
Structured Regularization ◽  
Functional Map

scholarly journals Ras Isoforms from Lab Benches to Lives—What Are We Missing and How Far Are We?

2021 ◽  
Vol 22 (12) ◽  
pp. 6508
Author(s):  
Arathi Nair ◽  
Katharina F. Kubatzky ◽  
Bhaskar Saha
Keyword(s):  
Protein Isoforms ◽  
Initial Assessment ◽  
Cell Type ◽  
Ras Genes ◽  
Ras Gtpase ◽  
Central Protein ◽  
Preferential Localization ◽  
Functional Map ◽  
Ras Isoforms ◽  
Cellular Organelles

The central protein in the oncogenic circuitry is the Ras GTPase that has been under intense scrutiny for the last four decades. From its discovery as a viral oncogene and its non–oncogenic contribution to crucial cellular functioning, an elaborate genetic, structural, and functional map of Ras is being created for its therapeutic targeting. Despite decades of research, there still exist lacunae in our understanding of Ras. The complexity of the Ras functioning is further exemplified by the fact that the three canonical Ras genes encode for four protein isoforms (H-Ras, K-Ras4A, K-Ras4B, and N-Ras). Contrary to the initial assessment that the H-, K-, and N-Ras isoforms are functionally similar, emerging data are uncovering crucial differences between them. These Ras isoforms exhibit not only cell–type and context-dependent functions but also activator and effector specificities on activation by the same receptor. Preferential localization of H-, K-, and N-Ras in different microdomains of the plasma membrane and cellular organelles like Golgi, endoplasmic reticulum, mitochondria, and endosome adds a new dimension to isoform-specific signaling and diverse functions. Herein, we review isoform-specific properties of Ras GTPase and highlight the importance of considering these towards generating effective isoform-specific therapies in the future.

scholarly journals Cortical Brain Functions – The Brodmann Legacy in the 21st Century

2017 ◽  
Vol 39 (04) ◽  
pp. 261-270
Author(s):  
Daniel Damiani ◽  
Anna Maria Nascimento ◽  
Leticia Kühl Pereira
Keyword(s):  
Brain Function ◽  
Imaging Techniques ◽  
Normal Brain ◽  
Functional Neuroanatomy ◽  
Brain Functions ◽  
Topographic Organization ◽  
Normal Brain Function ◽  
Magnetic Resonance Imaging Techniques ◽  
Functional Map ◽  
Functional Areas

AbstractIn 1909, Korbinian Brodmann described 52 functional brain areas, 43 of them found in the human brain. More than a century later, his devoted functional map was incremented by Glasser et al in 2016, using functional nuclear magnetic resonance imaging techniques to propose the existence of 180 functional areas in each hemisphere, based on their cortical thickness, degree of myelination (cortical myelin content), neuronal interconnection, topographic organization, multitask answers, and assessment in their resting state. This opens a huge possibility, through functional neuroanatomy, to understand a little more about normal brain function and its functional impairment in the presence of a disease.

What Happens Inside a Fuel Cell? Developing an Experimental Functional Map of Fuel Cell Performance

ChemPhysChem ◽  
2010 ◽  
Vol 11 (13) ◽  
pp. 2714-2731 ◽  
Author(s):  
Daniel J. L. Brett ◽  
Anthony R. Kucernak ◽  
Patricia Aguiar ◽  
Stephen C. Atkins ◽  
Nigel P. Brandon ◽  
...  
Keyword(s):  
Fuel Cell ◽  
Cell Performance ◽  
Fuel Cell Performance ◽  
Functional Map

scholarly journals Delineating the functional map of the interaction between nimotuzumab and the epidermal growth factor receptor

mAbs ◽  
2014 ◽  
Vol 6 (4) ◽  
pp. 1013-1025 ◽  
Author(s):  
Yaima Tundidor ◽  
Claudia Patricia García-Hernández ◽  
Amaury Pupo ◽  
Yanelys Cabrera Infante ◽  
Gertrudis Rojas
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Epidermal Growth ◽  
Functional Map

scholarly journals The functional organization of descending sensory-motor pathways in Drosophila

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Shigehiro Namiki ◽  
Michael H Dickinson ◽  
Allan M Wong ◽  
Wyatt Korff ◽  
Gwyneth M Card
Keyword(s):  
Nerve Cord ◽  
Functional Organization ◽  
Cell Types ◽  
The Body ◽  
Layered System ◽  
Descending Pathways ◽  
Motor Pathways ◽  
Transgenic Lines ◽  
Functional Map ◽  
The Brain

In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns across the DN population. We systematically investigated DN anatomy in Drosophila melanogaster and created over 100 transgenic lines targeting individual cell types. We identified roughly half of all Drosophila DNs and comprehensively map connectivity between sensory and motor neuropils in the brain and nerve cord, respectively. We find the nerve cord is a layered system of neuropils reflecting the fly’s capability for two largely independent means of locomotion -- walking and flight -- using distinct sets of appendages. Our results reveal the basic functional map of descending pathways in flies and provide tools for systematic interrogation of neural circuits.

Functional Map of the World

2018 ◽  
Author(s):  
Gordon Christie ◽  
Neil Fendley ◽  
James Wilson ◽  
Ryan Mukherjee
Keyword(s):  
The World ◽  
Functional Map

Functional map of the corticorubral projection in newborn kittens

1991 ◽  
Vol 16 ◽  
pp. 68
Author(s):  
Wen-Jie Song ◽  
Katsuya Okawa ◽  
Tooru Ohno ◽  
Fujio Murakami
Keyword(s):  
Functional Map
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