scholarly journals Metformin as targeted treatment in fragile X syndrome

2017 ◽  
Vol 93 (2) ◽  
pp. 216-222 ◽  
Author(s):  
A.B.C. Dy ◽  
F. Tassone ◽  
M. Eldeeb ◽  
M.J. Salcedo-Arellano ◽  
N. Tartaglia ◽  
...  
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Targeted Treatment

scholarly journals Fragile X Syndrome and Targeted Treatment Trials

2011 ◽  
pp. 297-335 ◽  
Author(s):  
Randi Hagerman ◽  
Julie Lauterborn ◽  
Jacky Au ◽  
Elizabeth Berry-Kravis
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Targeted Treatment ◽  
Treatment Trials

scholarly journals Early Intervention Combined with Targeted Treatment Promotes Cognitive and Behavioral Improvements in Young Children with Fragile X Syndrome

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Tri Indah Winarni ◽  
Andrea Schneider ◽  
Mariya Borodyanskara ◽  
Randi J. Hagerman
Keyword(s):  
Young Children ◽  
Fragile X Syndrome ◽  
Dendritic Spine ◽  
Environmental Enrichment ◽  
Fragile X ◽  
Educational Interventions ◽  
Targeted Treatment ◽  
Pharmacological Intervention ◽  
Cgg Repeats ◽  
And Behavior

Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability due to an expansion in the full mutation range (>200 CGG repeats) of the promoter region of theFMR1gene leading to gene silencing. Lack of FMRP, a critical protein for dendritic spine formation and maturation, will cause FXS. Early environmental enrichment combined with pharmacological intervention has been proven to rescue dendritic spine abnormalities in the animal model of FXS. Here we report on 2 young children with FXS who were treated early with a combination of targeted treatment and intensive educational interventions leading to improvement in their cognition and behavior and a normal IQ.

scholarly journals Fragile X syndrome, the search for a targeted treatment

2019 ◽  
Vol 5 (1) ◽  
pp. 12
Author(s):  
Shimriet Zeidler ◽  
Rob Willemsen
Keyword(s):  
Fragile X Syndrome ◽  
Neurodevelopmental Disorders ◽  
Fragile X ◽  
Short Review ◽  
Autism Spectrum ◽  
Targeted Treatment ◽  
Adequate Treatment ◽  
Model Studies ◽  
Physical Problems ◽  
Spectrum Disorders

Fragile X syndrome (FXS), the most common monogenetic cause of intellectual disability and autism spectrum disorders, is characterized by behavioral and physical problems. There is currently no adequate treatment available. While animal model studies seemed extremely promising, no success has been achieved in the larger clinical trials with human FXS patients. This short review describes the steps that have been taken in the development of a targeted treatment for FXS. Possible reasons for the lack of translation between animal models and human FXS patients are being explored and solutions are being proposed. The FXS story illustrates pitfalls and possibilities in translational research, that might especially be applicable for other neurodevelopmental disorders as well. 

scholarly journals Psychometric Study of the Aberrant Behavior Checklist in Fragile X Syndrome and Implications for Targeted Treatment

2011 ◽  
Vol 42 (7) ◽  
pp. 1377-1392 ◽  
Author(s):  
Stephanie M. Sansone ◽  
Keith F. Widaman ◽  
Scott S. Hall ◽  
Allan L. Reiss ◽  
Amy Lightbody ◽  
...  
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Targeted Treatment ◽  
Aberrant Behavior ◽  
Psychometric Study ◽  
Aberrant Behavior Checklist

scholarly journals Review of Autism Profiles and Response to Sertraline in Fragile X Syndrome-Associated Autism vs. Non-syndromic Autism; Next Steps for Targeted Treatment

2020 ◽  
Vol 11 ◽  
Author(s):  
Akash Rajaratnam ◽  
Laura Axelrod Potter ◽  
Hazel Maridith Barlahan Biag ◽  
Andrea Schneider ◽  
Ignacio Cortina Petrasic ◽  
...  
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X ◽  
Targeted Treatment ◽  
Syndromic Autism

Living with Fragile X Syndrome

2017 ◽  
Author(s):  
◽  
Rebecca Schira ◽  
Samantha Alexander ◽  
Noelani Brisbane ◽  
Kaitlyn Williams
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X

Fragile X Syndrome and Family Occupations

2019 ◽  
Author(s):  
Decerie Mendoza ◽  
Tracy Ye ◽  
Martina Dualan ◽  
Elena Javier
Keyword(s):  
Fragile X Syndrome ◽  
Fragile X
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