Erythropoietic protoporphyria a clinical and molecular study from Lebanon: Ferrochelatase a potential tumor suppressor gene in colon cancer

2017 ◽  
Vol 92 (5) ◽  
pp. 495-502 ◽  
Author(s):  
H. Kadara ◽  
G. Nemer ◽  
R. Safi ◽  
N. Rebeiz ◽  
L. Daou ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Molecular Study ◽  
Suppressor Gene ◽  
Erythropoietic Protoporphyria ◽  
Potential Tumor Suppressor

scholarly journals Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207776 ◽  
Author(s):  
María del Mar Noblejas-López ◽  
Sara Morcillo-García ◽  
Cristina Nieto-Jiménez ◽  
Miriam Nuncia-Cantarero ◽  
Balázs Győrffy ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Hormone Receptor ◽  
Breast Tumors ◽  
Suppressor Gene ◽  
Lung Adenocarcinomas ◽  
Potential Tumor Suppressor

scholarly journals The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer

2012 ◽  
Vol 42 (2) ◽  
pp. 676-682 ◽  
Author(s):  
RUI-SI XU ◽  
XIAO-DONG WU ◽  
SI-QI ZHANG ◽  
CHANG-FENG LI ◽  
LEI YANG ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Human Colon ◽  
Suppressor Gene ◽  
Human Colon Cancer ◽  
Novel Target

The NBL1 tumor suppressor gene is downregulated in colon cancer by promoter methylation

2004 ◽  
Vol 199 (3) ◽  
pp. 92 ◽  
Author(s):  
Jimmy C. Sung ◽  
Susan McCarthy ◽  
Joel Turner ◽  
C.G. Li ◽  
Timothy J. Yeatman
Keyword(s):  
Colon Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Promoter Methylation ◽  
Suppressor Gene

Abstract 3033: NKX2-5, a potential tumor suppressor gene in prostate cancer

2011 ◽  
Author(s):  
Mohammad Daremipouran ◽  
Song Ping Wang ◽  
Alexander Ellis ◽  
Zebalda Bamji ◽  
Bernard Kwabi-Addo
Keyword(s):  
Prostate Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Potential Tumor Suppressor

scholarly journals LARP7 is a potential tumor suppressor gene in gastric cancer

2012 ◽  
Vol 92 (7) ◽  
pp. 1013-1019 ◽  
Author(s):  
Yulan Cheng ◽  
Zhe Jin ◽  
Rachana Agarwal ◽  
Ke Ma ◽  
Jian Yang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Potential Tumor Suppressor

NTRK3 as a novel tumor suppressor gene in colorectal cancer.

2012 ◽  
Vol 30 (4_suppl) ◽  
pp. 469-469
Author(s):  
Yanxin Luo ◽  
Andrew Kaz ◽  
Samornmas Kanngurn ◽  
William M. Grady
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Tumor Suppressor ◽  
Cancer Cells ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Aberrant Methylation ◽  
Colon Cancer Cells ◽  
Colon Adenomas ◽  
Colon Cancer Cell Lines

469 Background: Neurotrophin tyrosine kinase receptor 3 (NTRK3) is a receptor tyrosine kinase that has been shown to be an oncogene in breast cancer and possibly in hepatocellular carcinoma. NTRK3 is a trophic dependence receptor, which is a recently described class of receptors that initiate signaling in both the ligand bound and unbound states. Through a genome-wide screen for aberrantly methylated genes, we identified aberrantly methylated NTRK3 as a frequently methylated gene in colon cancer. The aim for the present study is to determine if NTRK3 is an epigenetically silenced tumor suppressor gene in colorectal cancer. Methods: NTRK3 promoter methylation was analyzed in human colon cancer cell lines, normal colon epithelium tissue, colorectal adenomas and colorectal cancers using quantitative methylation-specific PCR and bisulfite sequencing. NTRK3 mRNA and protein expression were studied using quantitative real-time PCR, immunohistochemistry and western blotting respectively. The tumor suppressor function of NTRK3 was examined by assessing the effect of NTRK3 on cell apoptosis, cell migration and in vitro colony formation assays in colon cancer cell lines stably transfected with an NTRK3 expression construct in the presence or absence of NT-3. Results: NTRK3 is methylated in 60% of colon adenomas and in 57% of colorectal cancers. The aberrant methylation of NTRK3 suppresses NTRK3 expression and releases colon cancer cells from NTRK3 mediated apoptosis induced by the expression of NTRK3 in the absence of the ligand NT-3 via the activation of MAPK/ERK pathway. Methylation of NTRK3 also releases colon cancer cells from NTRK3 mediated suppression of motility and anchorage independent growth. The addition of NT3 to colon cancer cells transfected with NTRK3 inhibits the tumor suppressor effects of NTRK3. Conclusions: The aberrant methylation of NTRK3 is likely functionally relevant for colorectal cancer formation as NTRK3 appears to be a conditional tumor suppressor gene in the colon depending on the expression status of its ligand NT-3. NTRK3 is a novel aberrantly methylated conditional tumor suppressor gene that is frequently methylated in colon adenomas and cancers and whose discovery reveals possible novel treatment approaches to colon cancer.

W1097 Muc4: A Potential Tumor Suppressor Gene in Colon Carcinogenesis

2008 ◽  
Vol 134 (4) ◽  
pp. A-632
Author(s):  
Dhananjay Kunte ◽  
Surinder K. Batra ◽  
Thomas C. Smyrk ◽  
Ramesh K. Wali ◽  
Jennifer Koetsier ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Colon Carcinogenesis ◽  
Suppressor Gene ◽  
Potential Tumor Suppressor

scholarly journals Epigenetic silencing ofAristaless-like homeobox-4, a potential tumor suppressor gene associated with lung cancer

2013 ◽  
Vol 134 (6) ◽  
pp. 1311-1322 ◽  
Author(s):  
Wen-Bin Liu ◽  
Fei Han ◽  
Xing-Hua Du ◽  
Xiao Jiang ◽  
Yong-Hong Li ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Suppressor ◽  
Tumor Suppressor Gene ◽  
Suppressor Gene ◽  
Epigenetic Silencing ◽  
Potential Tumor Suppressor
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