MTHFR C677T and A1298C variants in Mexican Mestizo infants with neural tube defects from Western Mexico

2021 ◽  
Author(s):  
Cristian Irela Aranda‐Sánchez ◽  
Lucina Bobadilla‐Morales ◽  
Alfredo Corona‐Rivera ◽  
Idalid Cuero‐Quezada ◽  
Jennifer Santana‐Hernández ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Mthfr C677t ◽  
Mexican Mestizo ◽  
Western Mexico

Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents

Pathobiology ◽  
2019 ◽  
Vol 86 (4) ◽  
pp. 190-200
Author(s):  
Kaouther Nasri ◽  
Fatma Midani ◽  
Amani Kallel ◽  
Nadia Ben Jemaa ◽  
Mariem Aloui ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Mthfr C677t ◽  
Mthfr A1298c ◽  
C677t Mthfr ◽  
Mtrr A66g

scholarly journals Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

2015 ◽  
Vol 101 (6) ◽  
pp. 1286-1294 ◽  
Author(s):  
Becky L Tsang ◽  
Owen J Devine ◽  
Amy M Cordero ◽  
Claire M Marchetta ◽  
Joseph Mulinare ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Observational Studies ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Assessment Method ◽  
Percentage Difference ◽  
Lower Blood

ABSTRACTBackground: The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-processing capacity, which has been associated with lower blood folate concentrations.Objective: We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12–49 y.Design: We conducted a systematic review of the literature published from January 1992 to March 2014 to identify trials and observational studies that reported serum, plasma, or red blood cell (RBC) folate concentrations and MTHFR C677T genotype. We conducted a meta-analysis for estimates of percentage differences in blood folate concentrations between genotypes.Results: Forty studies met the inclusion criteria. Of the 6 studies that used the microbiologic assay (MA) to measure serum or plasma (S/P) and RBC folate concentrations, the percentage difference between genotypes showed a clear pattern of CC > CT > TT. The percentage difference was greatest for CC > TT [S/P: 13%; 95% credible interval (CrI): 7%, 18%; RBC: 16%; 95% CrI: 12%, 20%] followed by CC > CT (S/P: 7%; 95% CrI: 1%, 12%; RBC: 8%; 95% CrI: 4%, 12%) and CT > TT (S/P: 6%; 95% CrI: 1%, 11%; RBC: 9%; 95% CrI: 5%, 13%). S/P folate concentrations measured by using protein-binding assays (PBAs) also showed this pattern but to a greater extent (e.g., CC > TT: 20%; 95% CrI: 17%, 22%). In contrast, RBC folate concentrations measured by using PBAs did not show the same pattern and are presented in the Supplemental Material only.Conclusions: Meta-analysis results (limited to the MA, the recommended population assessment method) indicated a consistent percentage difference in S/P and RBC folate concentrations across MTHFR C677T genotypes. Lower blood folate concentrations associated with this polymorphism could have implications for a population-level risk of neural tube defects.

scholarly journals Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study

BMJ ◽  
2004 ◽  
Vol 328 (7455) ◽  
pp. 1535-1536 ◽  
Author(s):  
Peadar N Kirke ◽  
James L Mills ◽  
Anne M Molloy ◽  
Lawrence C Brody ◽  
Valerie B O'Leary ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Case Control Study ◽  
Mthfr C677t ◽  
Case Control ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism ◽  
Control Study

Lessons from dolutegravir and neural tube defects

2021 ◽  
Vol 8 (1) ◽  
pp. e3-e4
Author(s):  
Elaine Abrams ◽  
Landon Myer
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects

A Public Health Success Story: Folic Acid Fortification and Supplementation for Prevention of Neural Tube Defects

2004 ◽  
Author(s):  
Linda Longerich ◽  
Roy West ◽  
Ed Randell ◽  
Marian Crowley ◽  
Shiliang Liu ◽  
...  
Keyword(s):  
Public Health ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Success Story ◽  
Folic Acid Fortification
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