scholarly journals Simplein vitromigration assay for neural crest cells and the opposite effects of all-trans-retinoic acid on cephalic- and trunk-derived cells

2014 ◽  
Vol 54 (3) ◽  
pp. 184-188 ◽  
Author(s):  
Makoto Usami ◽  
Katsuyoshi Mitsunaga ◽  
Tomohiko Irie ◽  
Atsuko Miyajima ◽  
Osamu Doi
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

v-erbA and citral reduce the teratogenic effects of all-trans retinoic acid and retinol, respectively, in Xenopus embryogenesis

Development ◽  
1993 ◽  
Vol 119 (3) ◽  
pp. 785-798 ◽  
Author(s):  
T.J. Schuh ◽  
B.L. Hall ◽  
J.C. Kraft ◽  
M.L. Privalsky ◽  
D. Kimelman
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Gastrula Stage ◽  
Teratogenic Effects ◽  
Retinoic Acid Signalling ◽  
Xenopus Development ◽  
Xenopus Embryos ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Treatment of late blastula/early gastrula stage Xenopus embryos with all-trans retinoic acid results in disruption of the primary body axis through effects on both mesoderm and neuroectoderm. This effect of retinoic acid, coupled with the known presence of retinoic acid in Xenopus embryos has led to the proposal that retinoic acid may be an endogenous morphogen providing positional information in early development. To further elucidate the role of retinoic acid in early Xenopus development, we have attempted to interfere with the retinoic acid signalling pathway both at the level of retinoic acid formation, by treatment with citral (3,7-dimethy-2,6-octadienal), and at the level of nuclear retinoic acid receptor function, by microinjection of v-erbA mRNA. The feasibility of this approach was demonstrated by the ability of citral treatment and v-erbA mRNA injection to reduce the teratogenic effects of exogenous retinol and retinoic acid, respectively, in early Xenopus development. Interestingly, v-erbA mRNA injection and citral treatment of gastrula stage embryos resulted in tadpoles with a similar set of developmental defects. The defects were chiefly found in tissues that received a contribution of cells from the neural crest, suggesting that at least a subset of neural crest cells may be sensitive to the endogenous level of retinoic acid. In accord with this proposal, it was found that the expression patterns of two early markers of cranial neural crest cells, Xtwi and XAP-2, were altered in embryos injected with v-erbA mRNA. These results indicate that structures in addition to the primary axis are regulated by retinoic acid signalling during early Xenopus development.

Abnormal neural crest innervation in Sox10-Venus mice with all-trans retinoic acid-induced anorectal malformations

2013 ◽  
Vol 30 (2) ◽  
pp. 189-195 ◽  
Author(s):  
Ryota Suzuki ◽  
Katsumi Miyahara ◽  
Hiroshi Murakami ◽  
Takashi Doi ◽  
Geoffrey J. Lane ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Neural Crest ◽  
Anorectal Malformations ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid

Antiproliferative effect of all-trans-retinoic acid in cholangiocarcinoma

2017 ◽  
Author(s):  
A Prawan ◽  
S Butsri ◽  
V Kukongviriyapan ◽  
L Senggunprai ◽  
S Kongpetch
Keyword(s):  
Retinoic Acid ◽  
Antiproliferative Effect ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid
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