Aqueous seeding in intraocular retinoblastoma: A review

2021 ◽  
Author(s):  
Swathi Kaliki
Keyword(s):  
Intraocular Retinoblastoma

Modern Possibilities of Organ-Preserving Treatment in Children with Intraocular Retinoblastoma

2018 ◽  
Vol 5 (3) ◽  
pp. 175-187 ◽  
Author(s):  
O. V. Gorovtsova ◽  
T. L. Ushakova ◽  
V. G. Polyakov
Keyword(s):  
Drug Delivery ◽  
Survival Rate ◽  
Cancer Therapy ◽  
Neoadjuvant Chemotherapy ◽  
Patient Survival ◽  
Focal Therapy ◽  
Local Drug Delivery ◽  
Large Size ◽  
Intraocular Retinoblastoma

Retinoblastoma is one of highly curable diseases; today the total 5-year survival rate in patients with retinoblastoma exceeds 95%. The article summarizes the current world experience on treatment of patients with intraocular retinoblastoma. The treating skills of intraocular malignant tumor in children are a balance between the patient’s life and the preservation of an eye and its visual functions. The complex and challenging task is the treatment of common intraocular retinoblastoma groups «C», «D», «E» when the large size or localization of the tumor does not allow performing the local (focal) destruction of the tumor. As a rule, in such cases neoadjuvant chemotherapy (CT) is performed at the first stage in order to reduce the size of the tumor for further focal therapy. However, the analysed data on the effectiveness of neoadjuvant CT in combination with focal or radiotherapy demonstrated the limited possibilities of the proposed therapy. Local drug delivery in cancer therapy became a real breakthrough in the organ-preserving treatment of children with large intraocular retinoblastoma. The most widely used current methods of local drug delivery are intravitreal (IVitC) and selective intra-arterial chemotherapy (SIAC) as monotherapy or in combination with neoadjuvant CT and focal therapy which significantly increased the percentage of preserved eyes without radiotherapy administration or damage to the patient survival. The review discusses the different IVitC and SIAC techniques, chemotherapy schemes, dosages of chemotherapy, immediate and long-term complications of treatment.

scholarly journals Response criteria for intraocular retinoblastoma: RB‐RECIST

2021 ◽  
Vol 68 (5) ◽  
Author(s):  
Jesse L. Berry ◽  
Francis L. Munier ◽  
Brenda L. Gallie ◽  
Ashley Polski ◽  
Sona Shah ◽  
...  
Keyword(s):  
Response Criteria ◽  
Intraocular Retinoblastoma

scholarly journals Risk factors for ophthalmic artery stenosis and occlusion in patients with retinoblastoma treated with intra-arterial chemotherapy

2021 ◽  
pp. bjophthalmol-2021-319118
Author(s):  
Min Zhou ◽  
Xuyang Wen ◽  
Shichong Jia ◽  
Yanping Han ◽  
Xiaoyu He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Ophthalmic Artery ◽  
Cox Regression ◽  
Median Number ◽  
Disease Stage ◽  
Orifice Diameter ◽  
Clinical Predictors ◽  
Total Incidence ◽  
Intraocular Retinoblastoma ◽  
Stenosis And Occlusion

PurposeTo explore the risk factors for ophthalmic artery (OA) stenosis and occlusion after intra-arterial chemotherapy (IAC) with selective ophthalmic artery catheterisation (OAC) in the treatment of retinoblastoma.DesignRetrospective, single centre case-control study.MethodsThe study was conducted including consecutive patients with unilateral or bilateral intraocular retinoblastoma undergoing IAC between June 2016 and June 2019 with a follow-up time of 4 years. Main outcomes are rate of IAC-induced OA occlusion and OA diameter.Results346 attempted OAC infusions were successful. The total incidence of OA occlusion was 15.89%. The occlusion and control groups were similar in patients’ age, sex and disease stage. Median OA diameter was 0.49 mm in those with OA occlusion, and 0.66 mm in those without occlusion. In the occlusion group, the OA diameter difference was significantly larger between the first IAC and the final IAC (0.22mm vs 0.12mm, p=0.001). In both groups, the median number of IAC treatments was 3. Multivariate Cox regression models included initial OA diameter (OR: 0.005, p=0.001), ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter (OR: 4.661, p=0.003), and number of IAC (OR: 1.538, p=0.042) as clinical features significantly associated with OA occlusion.ConclusionsThe OA diameter at first IAC treatment, the ratio of OA orifice diameter differences between first and last IAC to the initial OA orifice diameter and total number of IAC treatments may be three main clinical predictors for OA occlusion after IAC for retinoblastoma.

scholarly journals Spatiotemporal Patterns of Tumor Occurrence in Children with Intraocular Retinoblastoma

PLoS ONE ◽  
2015 ◽  
Vol 10 (7) ◽  
pp. e0132932 ◽  
Author(s):  
Benjamin A. King ◽  
Carlos Parra ◽  
Yimei Li ◽  
Kathleen J. Helton ◽  
Ibrahim Qaddoumi ◽  
...  
Keyword(s):  
Spatiotemporal Patterns ◽  
Intraocular Retinoblastoma

DE NOVO INTRAOCULAR RETINOBLASTOMA DEVELOPMENT AFTER CHEMOTHERAPY IN PATIENTS WITH HEREDITARY RETINOBLASTOMA

Retina ◽  
2006 ◽  
Vol 26 (4) ◽  
pp. 425-431 ◽  
Author(s):  
ANDREAS O. SCHUELER ◽  
GERASIMOS ANASTASSIOU ◽  
CHRISTINE JURKLIES ◽  
WERNER HAVERS ◽  
REGINA WIELAND ◽  
...  
Keyword(s):  
De Novo ◽  
Intraocular Retinoblastoma

scholarly journals Analysis of the short-term curative effect of 356 cases of intraocular retinoblastoma in children

2018 ◽  
Vol 2 (4) ◽  
pp. 236-241 ◽  
Author(s):  
Mei Jin ◽  
Junyang Zhao ◽  
Dawei Zhang ◽  
Chengyue Zhang ◽  
Wen Zhao ◽  
...  
Keyword(s):  
Short Term ◽  
Curative Effect ◽  
Intraocular Retinoblastoma

Socioeconomic and psychological impact of treatment for unilateral intraocular retinoblastoma

2015 ◽  
Vol 38 (6) ◽  
pp. 550-558 ◽  
Author(s):  
S.E. Soliman ◽  
H. Dimaras ◽  
A.A. Souka ◽  
M.H. Ashry ◽  
B.L. Gallie
Keyword(s):  
Psychological Impact ◽  
Intraocular Retinoblastoma
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