scholarly journals Association of long-term glycaemic control on tear break-up times and dry eye symptoms in Chinese patients with type 2 diabetes

2018 ◽  
Vol 46 (6) ◽  
pp. 608-615 ◽  
Author(s):  
Andre Ma ◽  
Martin SY Mak ◽  
Kendrick Co Shih ◽  
Claudia KY Tsui ◽  
Rachel KY Cheung ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Dry Eye ◽  
Chinese Patients ◽  
Eye Symptoms ◽  
Break Up ◽  
Dry Eye Symptoms

scholarly journals Clinical Characteristics and Risk of Diabetic Complications in Data-Driven Clusters Among Type 2 Diabetes

2021 ◽  
Vol 12 ◽  
Author(s):  
Lin Xing ◽  
Fangyu Peng ◽  
Qian Liang ◽  
Xiaoshuang Dai ◽  
Junli Ren ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Complications ◽  
Clinical Characteristics ◽  
Chinese Patients ◽  
Newly Diagnosed ◽  
Medication Treatment ◽  
Dipeptidyl Peptidase 4 ◽  
Age Related

BackgroundThis study aimed to cluster newly diagnosed patients and patients with long-term diabetes and to explore the clinical characteristics, risk of diabetes complications, and medication treatment related to each cluster.Research Design and MethodsK-means clustering analysis was performed on 1,060 Chinese patients with type 2 diabetes based on five variables (HbA1c, age at diagnosis, BMI, HOMA2-IR, and HOMA2-B). The clinical features, risk of diabetic complications, and the utilization of elven types of medications agents related to each cluster were evaluated with the chi-square test and the Tukey–Kramer method.ResultsFour replicable clusters were identified, severe insulin-resistant diabetes (SIRD), severe insulin-deficient diabetes (SIDD), mild obesity-related diabetes (MOD), and mild age-related diabetes (MARD). In terms of clinical characteristics, there were significant differences in blood pressure, renal function, and lipids among clusters. Furthermore, individuals in SIRD had the highest prevalence of stages 2 and 3 chronic kidney disease (CKD) (57%) and diabetic peripheral neuropathy (DPN) (67%), while individuals in SIDD had the highest risk of diabetic retinopathy (32%), albuminuria (31%) and lower extremity arterial disease (LEAD) (13%). Additionally, the difference in medication treatment of clusters were observed in metformin (p = 0.012), α-glucosidase inhibitor (AGI) (p = 0.006), dipeptidyl peptidase 4 inhibitor (DPP-4) (p = 0.017), glucagon-like peptide-1 (GLP-1) (p <0.001), insulin (p <0.001), and statins (p = 0.006).ConclusionsThe newly diagnosed patients and patients with long-term diabetes can be consistently clustered into featured clusters. Each cluster had significantly different patient characteristics, risk of diabetic complications, and medication treatment.

The overtreatment of type 2 diabetes in frail older people

2020 ◽  
Vol 2 (9) ◽  
pp. 496-502
Author(s):  
Hannah Syed
Keyword(s):  
Type 2 Diabetes ◽  
Glycaemic Control ◽  
Older People ◽  
Diabetes Management ◽  
Holistic Approach ◽  
Protective Effects ◽  
Frail Older People ◽  
Good Glycaemic Control

Intensive treatment with insulin and sulfonylureas in older people with low HbA1c (<53mmol/mol) can increase the risk of hypoglycaemia, morbidity and mortality. Older people, particularly those with frailty and/or comorbidities are less likely to benefit from the long-term protective effects of good glycaemic control and are often at risk of inappropriate polypharmacy. A person-centred holistic approach to diabetes management must be adapted for older people living with diabetes.

scholarly journals Relation of accommodative microfluctuation with dry eye symptoms in short tear break-up time dry eye

PLoS ONE ◽  
2017 ◽  
Vol 12 (9) ◽  
pp. e0184296 ◽  
Author(s):  
Minako Kaido ◽  
Motoko Kawashima ◽  
Yuta Shigeno ◽  
Yoshiaki Yamada ◽  
Kazuo Tsubota
Keyword(s):  
Dry Eye ◽  
Eye Symptoms ◽  
Break Up ◽  
Dry Eye Symptoms

scholarly journals Long-term effect of dietary fibre intake on glycosylated haemoglobin A1c level and glycaemic control status among Chinese patients with type 2 diabetes mellitus

2013 ◽  
Vol 17 (8) ◽  
pp. 1858-1864 ◽  
Author(s):  
Luxi Yang ◽  
Le Shu ◽  
Junyi Jiang ◽  
Hua Qiu ◽  
Genming Zhao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Fibre ◽  
Chinese Patients ◽  
Haemoglobin A1c ◽  
Fibre Intake ◽  
Long Term Effect

AbstractObjectiveDietary fibre has been linked to lower levels of glycosylated haemoglobin A1c (HbA1c) among diabetes patients. The present study aimed to evaluate the long-term effect of dietary fibre on HbA1c levels among Chinese patients with type 2 diabetes mellitus.DesignTwo cross-sectional surveys were conducted in 2006 and 2011, with the second one being a repeat survey on a sub-sample from the initial one. In both surveys, an in-person interview was conducted to collect information on demographic characteristics and lifestyles following a similar protocol. Dietary intake was assessed with a validated FFQ. Anthropometric measures and biochemical assays were performed at the interview.SettingCommunities in Pudong New Area of Shanghai, China.SubjectsChinese patients (n 934) with type 2 diabetes mellitus.ResultsAn inverse association was observed between dietary fibre and glycaemic status indicated by HbA1c level in both surveys, although it was significant only in the first survey. Among 497 patients participating in both surveys, dietary fibre intake at the first survey was inversely associated with uncontrolled glycaemic status at the second survey, with adjusted odds ratios across the tertiles of intake being 1·00, 0·72 (95 % CI 0·43, 1·21) and 0·58 (95 % CI 0·34, 0·99; Ptrend = 0·048). The change in fibre intake was slightly associated with glycaemic status, with each increase in tertile scores of intake linked to a 0·138 % (β = −0·138; 95 % CI −0·002, 0·278) decrease in HbA1c value and a 19 % (OR = 0·81; 95 % CI 0·65, 1·02) reduced risk of uncontrolled glycaemic status at the second survey.ConclusionsDietary fibre may have a long-term beneficial effect on HbA1c level among Chinese diabetes patients.

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