Unusual concomitant small and large fiber neuropathy related to hypereosinophilic syndrome

2021 ◽  
Author(s):  
Elena Merico ◽  
Alessandra Govoni ◽  
Erika Schirinzi ◽  
Lucia Chico ◽  
Giulia Ricci ◽  
...  
Keyword(s):  
Hypereosinophilic Syndrome ◽  
Large Fiber ◽  
Large Fiber Neuropathy

A reappraisal of the presence of small or large fiber neuropathy in patients with erythromelalgia

2021 ◽  
Author(s):  
Pauline Reach ◽  
Isabelle Lazareth ◽  
François Coudore ◽  
Audrey Stansal ◽  
Raphaël Attal ◽  
...  
Keyword(s):  
Large Fiber ◽  
Large Fiber Neuropathy

MO45 Peripheral large fiber neuropathy in patients with erectile dysfunction

2008 ◽  
Vol 119 ◽  
pp. S42
Author(s):  
Consuelo Valles-Antuña ◽  
Jesús M Fernández-Gómez ◽  
Safwan Escaf-Barmadah ◽  
Jose Luis Martín-Benito ◽  
Fernando Fernández-González
Keyword(s):  
Erectile Dysfunction ◽  
Large Fiber ◽  
Large Fiber Neuropathy

Small and large fiber neuropathy in those with type 1 and type 2 diabetes: a 5-year follow-up study

2016 ◽  
Vol 21 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Sissel Løseth ◽  
Erik V. Stålberg ◽  
Sigurd Lindal ◽  
Edel Olsen ◽  
Rolf Jorde ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Follow Up Study ◽  
Large Fiber ◽  
Large Fiber Neuropathy

scholarly journals Neuropathic pain in adult Myotonic Dystrophy type 1.  Presence of small and large fibre neuropathy?

2020 ◽  
Author(s):  
Gro Solbakken ◽  
Sissel Løseth ◽  
Terje Nærland ◽  
Jan Frich ◽  
Espen Dietrichs ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Myotonic Dystrophy Type 1 ◽  
Myotonic Dystrophy Type ◽  
Fiber Density ◽  
Epidermal Nerve Fiber Density ◽  
Large Fiber ◽  
Nerve Fiber Density ◽  
Large Fiber Neuropathy ◽  
Epidermal Nerve Fiber

Abstract Background: Myotonic Dystrophy type 1 (DM1) is an inherited neuromuscular disorder affecting multiple organs. There is an increasing awareness of chronic pain in DM1. In this cross-sectional study, we investigated symptoms of neuropathic pain and small and large fiber neuropathy in the adult form of DM1. We also studied if neuropathy was related to the number of CTG repeats, disease duration and other clinical DM1 symptoms, and investigated if skin biopsy tests for small fiber neuropathy differed in the DM1 group compared to reference values from healthy controls.Methods: 20 genetically verified DM1 adult patients were included in the study. Pain descriptions, neurologic examination and objective investigations of the peripheral nerve system by quantitative sensory testing, skin biopsies and neurography were conducted. Statistical analyses of group differences and frequencies were performed.Results: Six patients (30%) out of 20 patients with DM1 described neuropathic pain, and three of these had objective findings on both small and large fiber neuropathy, as well as clinically sensory findings. Together, large and/or small fibre neuropathy is present in 50% of the patients with DM1. The intra epidermal nerve fiber density was significantly lower (p= <0.001, Cohen`s d = 1.2) in the 20 patients with DM1 (mean 8.16, SD: 2.28) compared to a reference group (N = 106, mean 12.43, SD: 4.59). Patients with large fiber neuropathy had significantly lower muscle strength (p = 0.01, Cohen`s d = 1.6, mean difference 0.4, CI: 0.7 - 0.1) than patients without large fiber neuropathy.Conclusion: Symptoms of neuropathic pain was more frequent in patients with DM1 compared to the general population. Intra epidermal nerve fiber density was significantly lower in the DM1 group than in a sample of healthy controls. Neuropathy may be a mechanism of pain in DM1.

scholarly journals Large-Fiber Neuropathy in Parkinson’s Disease: Clinical, Biological, and Electroneurographic Assessment of a Romanian Cohort

2019 ◽  
Vol 8 (10) ◽  
pp. 1533
Author(s):  
Oana Maria Vanta ◽  
Nicoleta Tohanean ◽  
Sebastian Pintea ◽  
Lacramioara Perju-Dumbrava
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Vitamin B12 ◽  
Sensory Nerve ◽  
Vitamin B12 Deficiency ◽  
Biological Evaluation ◽  
Cross Sectional ◽  
Daily Dose ◽  
Large Fiber ◽  
Large Fiber Neuropathy

(1) Background: Increased attention has lately been given to polyneuropathy in Parkinson’s Disease (PD). Several papers postulated that large-fiber neuropathy (PNP) in PD is related to vitamin B12 deficiency and L-Dopa exposure. (2) Methods: Using a cross-sectional, observational study, we evaluated 73 PD patients without a previously known cause of PNP using clinical scores (UPDRS II and III and Toronto Clinical Scoring System), biological evaluation of vitamin B12 and folic acid, and nerve conduction studies to assess the prevalence and features of PNP. (3) Results: The prevalence of PNP was 49.3% in the study group. In the L-Dopa group, the frequency of PNP was 67.3% as compared to PNP in the non-L-Dopa group, where one subject had PNP (χ2 = 23.41, p < 0.01). PNP was predominantly sensory with mild to moderate axonal loss. Cyanocobalamin correlated with L-Dopa daily dose (r = −0.287, p < 0.05) and L-Dopa duration of administration (r = −0.316, p < 0.05). L-Dopa daily dose correlated with the amplitudes of sensory nerve action potentials of the superficial peroneal and radial nerves (r = −0.312, p < 0.05) (r = −0.336, p < 0.05), respectively. (4) Conclusions: PNP is more frequent in L-Dopa-treated patients than in L-Dopa-naïve patients. The results imply that longer exposure to high doses of L-Dopa may cause vitamin B12 and folate imbalance and PNP, secondarily.

scholarly journals A Case-Control study of the prevalence of neurological diseases in inflammatory bowel disease (IBD)

2015 ◽  
Vol 73 (2) ◽  
pp. 119-124 ◽  
Author(s):  
Francisco de Assis Aquino Gondim ◽  
Gisele Ramos de Oliveira ◽  
Benedito Cadorno V. Teles ◽  
Marcellus H.L.P. Souza ◽  
Lucia L.B.C. Braga ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Neuromuscular Diseases ◽  
Electrodiagnostic Testing ◽  
Inflammatory Bowel ◽  
Large Fiber ◽  
Control Study ◽  
Large Fiber Neuropathy

Neurological diseases are common in inflammatory bowel disease (IBD) patients, but their exact prevalence is unknown. Method We prospectively evaluated the presence of neurological disorders in 121 patients with IBD [51 with Crohn's disease (CD) and 70 with ulcerative colitis (UC)] and 50 controls (gastritis and dyspepsia) over 3 years. Results Our standard neurological evaluation (that included electrodiagnostic testing) revealed that CD patients were 7.4 times more likely to develop large-fiber neuropathy than controls (p = 0.045), 7.1 times more likely to develop any type of neuromuscular condition (p = 0.001) and 5.1 times more likely to develop autonomic complaints (p = 0.027). UC patients were 5 times more likely to develop large-fiber neuropathy (p = 0.027) and 3.1 times more likely to develop any type of neuromuscular condition (p = 0.015). Conclusion In summary, this is the first study to prospectively establish that both CD and UC patients are more prone to neuromuscular diseases than patients with gastritis and dyspepsia.

scholarly journals Small- and Large-Fiber Neuropathy After 40 Years of Type 1 Diabetes: Associations with glycemic control and advanced protein glycation: the Oslo Study

Diabetes Care ◽  
2013 ◽  
Vol 36 (11) ◽  
pp. 3712-3717 ◽  
Author(s):  
K. A. Sveen ◽  
B. Karime ◽  
E. Jorum ◽  
S. I. Mellgren ◽  
M. W. Fagerland ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Glycemic Control ◽  
Protein Glycation ◽  
Large Fiber ◽  
Large Fiber Neuropathy
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