IL‐19 ameliorates experimental autoimmune encephalitis

2021 ◽  
Author(s):  
Hideyuki Takeuchi ◽  
Hiroshi Horiuchi ◽  
Bijay Parajuli ◽  
Hiroyasu Komiya ◽  
Fumiaki Tanaka ◽  
...  
Keyword(s):  
Autoimmune Encephalitis ◽  
Experimental Autoimmune Encephalitis ◽  
Experimental Autoimmune

scholarly journals Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis

2010 ◽  
Vol 47 (10) ◽  
pp. 1890-1898 ◽  
Author(s):  
Menachem Bitan ◽  
Lola Weiss ◽  
Israel Reibstein ◽  
Michael Zeira ◽  
Yakov Fellig ◽  
...  
Keyword(s):  
Autoimmune Encephalitis ◽  
Th2 Cytokines ◽  
Experimental Autoimmune Encephalitis ◽  
Experimental Autoimmune

Multiple sclerosis pathogenesis: missing pieces of an old puzzle

2018 ◽  
Vol 30 (1) ◽  
pp. 67-83 ◽  
Author(s):  
Reza Rahmanzadeh ◽  
Wolfgang Brück ◽  
Alireza Minagar ◽  
Mohammad Ali Sahraian
Keyword(s):  
Multiple Sclerosis ◽  
Cd8 T Cells ◽  
Autoimmune Encephalitis ◽  
Cd4 T Cell ◽  
Experimental Autoimmune Encephalitis ◽  
Focal Lesions ◽  
Multiple Sclerosis Pathogenesis ◽  
Cns Autoimmunity ◽  
Ms Pathogenesis ◽  
Experimental Autoimmune

Abstract Traditionally, multiple sclerosis (MS) was considered to be a CD4 T cell-mediated CNS autoimmunity, compatible with experimental autoimmune encephalitis model, which can be characterized by focal lesions in the white matter. However, studies of recent decades revealed several missing pieces of MS puzzle and showed that MS pathogenesis is more complex than the traditional view and may include the following: a primary degenerative process (e.g. oligodendroglial pathology), generalized abnormality of normal-appearing brain tissue, pronounced gray matter pathology, involvement of innate immunity, and CD8 T cells and B cells. Here, we review these findings and discuss their implications in MS pathogenesis.

Experimental autoimmune encephalitis in cytokine gene knockout mice

1998 ◽  
Vol 90 (1) ◽  
pp. 4
Author(s):  
A. Fontana ◽  
H.-P. Eugster ◽  
K. Frei ◽  
H. Lassmann ◽  
U. Malipiero ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Gene Knockout ◽  
Autoimmune Encephalitis ◽  
Cytokine Gene ◽  
Experimental Autoimmune Encephalitis ◽  
Gene Knockout Mice ◽  
Experimental Autoimmune
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