scholarly journals Peripheral blood T cell subset characteristics of multiple sclerosis in remission phase correlate with annualized relapse rates

2016 ◽  
Vol 7 (4) ◽  
pp. 346-352 ◽  
Author(s):  
Zi-Ye Song ◽  
Yuri Nakamura ◽  
Ryo Yamasaki ◽  
Yuji Kawano ◽  
Koji Shinoda ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Peripheral Blood ◽  
Cell Subset ◽  
T Cell Subset ◽  
Remission Phase ◽  
Relapse Rates

scholarly journals The CD8+ granzyme B+ T-cell subset in peripheral blood from healthy individuals contains activated and apoptosis-prone cells

Immunology ◽  
2001 ◽  
Vol 93 (3) ◽  
pp. 383-389 ◽  
Author(s):  
WEVER ◽  
VAN DER VLIET ◽  
SPAENY ◽  
WOLBINK ◽  
VAN DIEPEN ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Granzyme B ◽  
Cell Subset ◽  
Healthy Individuals ◽  
T Cell Subset

The CD4+ T-cell subset lacking expression of the CD28 costimulatory molecule is expanded and shows a higher activation state in multiple sclerosis

2012 ◽  
Vol 243 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
María Jesús Pinto-Medel ◽  
Juan Antonio García-León ◽  
Begoña Oliver-Martos ◽  
Carlos López-Gómez ◽  
Gloria Luque ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Costimulatory Molecule ◽  
Cell Subset ◽  
Cd4 T Cell ◽  
T Cell Subset

scholarly journals Application of Immunohistochemistry to Monitor the CD3+T Cell Subset Counts in Patients with Sepsis

2021 ◽  
Author(s):  
Ronghua Deng ◽  
Lan Deng ◽  
Yamin Tian ◽  
Guopeng Deng ◽  
Jiannan Zeng ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cell Subset ◽  
Sepsis Group ◽  
Blood Samples ◽  
T Cell Subset ◽  
Blood Tests ◽  
Control Subjects ◽  
Routine Blood ◽  
Healthy Control

Abstract [Objective]: To evaluate the application significance of Immunohistochemistry for monitoring peripheral blood CD3 + T cell subset (CD3+/CD3 + CD4+/CD3 + CD8+) counts in patients with sepsis.[Methods]: Two peripheral blood samples of 117 patients with sepsis on the first day of admission (D1) and 20 healthy control subjects were collected, and two peripheral blood samples of 20 patients with sepsis on the fourth day of admission (D4) were randomly collected and used to detect the lymphocyte counts of routine blood tests and CD3 + T cell subset count by Immunohistochemistry; the lymphocyte count levels between the sepsis group and the healthy control group were compared, and the correlation between the two in the same group were analyzed.[Results]:lymphocyte counts by routine blood tests and CD3 + T cell subset counts of patients with sepsis were significantly lower than those in healthy control subjects (P < 0.01). In the surviving group, the mean values of D4 CD3 + T cell subset counts increased significantly compared with D1, while the nonsurviving group did not rebound significantly; There was a significant positive correlation between lymphocyte counts by routine blood tests and CD3 + T lymphocyte subset counts in patients with sepsis and the healthy control subjects. (P < 0.01).[Conclusion]: Detection of CD3 + T cell subset counts by immunohistochemical method can reflect the cellular immune status of patients at a given time, thus it can be used as one of the immune monitoring methods in patients with sepsis.

scholarly journals Analysis using canine peripheral blood for establishing in vitro conditions for monocyte differentiation into macrophages for Leishmania chagasi infection and T-cell subset purification

2013 ◽  
Vol 198 (1-2) ◽  
pp. 62-71 ◽  
Author(s):  
Kelvinson Fernandes Viana ◽  
Rodrigo Dian Oliveira Aguiar-Soares ◽  
Bruno Mendes Roatt ◽  
Lucilene Aparecida Resende ◽  
Denise da Silveira-Lemos ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cell Subset ◽  
Leishmania Chagasi ◽  
Monocyte Differentiation ◽  
T Cell Subset

Quantitative changes within the peripheral blood CD8highCD57+ T-cell subpopulation of patients with advanced renal cell carcinoma

2014 ◽  
Vol 20 (4) ◽  
pp. 147-159
Author(s):  
Marius Strioga ◽  
Vita Pašukonienė ◽  
Neringa Dobrovolskienė ◽  
Tadas Petraitis ◽  
Nijolė Kazlauskaitė ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Cell Carcinoma ◽  
Peripheral Blood ◽  
Renal Cell ◽  
Cell Subset ◽  
Cell Subpopulation ◽  
T Cell Subset

Background. Antitumor immunotherapy strategies, such as cytokine- based or cell-based immunotherapies, are designed to activate immune response against cancer cells, but considering that malignancy may be associated with the expansion of immunosuppressive components of antitumor immunity, it is likely that in such cases activation of the immune system would further enhance activity of these components, leading to more severe suppression of antitumor immune response thus making more favourable conditions for tumor progression. Materials and methods. We studied the expression of biomarkers, representing immunosuppressive (FOXP3) and cytotoxic (perforin, IFN-γ) CD8highCD57+ T-cell subpopulation functions in the peripheral blood of 34 patients with advanced clear cell renal cell carcinoma (RCC) and 26 controls by multicolour flow cytometry. Results. CD8highCD57+ T cell subpopulation of all CD8+ T cells in RCC patients was significantly higher compared to age-matched healthy controls (p = 0.003). It was found that the mean percentage of suppressive CD8highCD57+FOXP3+ T-cell subset and cytotoxic CD8highCD57+Perforin+ T-cell subset in the CD8highCD57+ T-cell subpopulation was significantly increased in RCC patients compared to controls (p = 0.0004 and p = 0.008, respectively). There was no strong and biologically relevant negative correlation between the expression of FOXP3 and Perforin in the peripheral blood CD8highCD57+ T-cell subpopulation of RCC patients. Conclusions. Subsets of immunosuppressive FOXP3+ T cell and tumor-attacking (cytotoxic) Perforin+ T cells in the CD8highCD57+ T-cell subpopulation are significantly increased in RCC patients compared to controls. These quantitative rearrangements are independent and individual for each RCC patient.

Presence of T-cell subset abnormalities in newly diagnosed cases of multiple sclerosis and relationship with short-term clinical activity

1993 ◽  
Vol 240 (2) ◽  
pp. 79-82 ◽  
Author(s):  
M. Eoli ◽  
M. Ferrarini ◽  
A. Dufour ◽  
S. Heltaj ◽  
L. Bevilacqua ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
Cell Subset ◽  
Clinical Activity ◽  
Newly Diagnosed ◽  
Short Term ◽  
T Cell Subset

Peripheral blood T cell subset phenotype analysis in melanoma patients treated with combination nivolumab + ipilimumab compared to ipilimumab alone.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3073-3073 ◽  
Author(s):  
Michael Andrew Postow ◽  
Deborah Kuk ◽  
Matthew Adamow ◽  
Cristina Carrera ◽  
Phillip Wong ◽  
...  
Keyword(s):  
T Cell ◽  
Peripheral Blood ◽  
Cell Subset ◽  
T Cell Subset ◽  
Phenotype Analysis ◽  
Melanoma Patients
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