Stable human brain microvascular endothelial cell line retaining its barrier-specific nature independent of the passage number

2012 ◽  
Vol 4 (1) ◽  
pp. 92-103 ◽  
Author(s):  
Yasuteru Sano ◽  
Yoko Kashiwamura ◽  
Masaaki Abe ◽  
Le-Ha Dieu ◽  
Jörg Huwyler ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Human Brain ◽  
Cell Line ◽  
Microvascular Endothelial Cell ◽  
Brain Microvascular Endothelial Cell ◽  
Specific Nature ◽  
Endothelial Cell Line ◽  
Passage Number ◽  
Microvascular Endothelial

Endothelin-1 production by a microvascular endothelial cell line treated with Plasmodium falciparum parasitized red blood cells

2002 ◽  
Vol 103 (s2002) ◽  
pp. 464S-466S ◽  
Author(s):  
Nicoletta BASILICO ◽  
Livianna SPECIALE ◽  
Silvia PARAPINI ◽  
Pasquale FERRANTE ◽  
Donatella TARAMELLI
Keyword(s):  
Plasmodium Falciparum ◽  
Endothelial Cell ◽  
Red Blood Cells ◽  
Cell Line ◽  
Blood Cells ◽  
Microvascular Endothelial Cell ◽  
Microvascular Endothelium ◽  
Endothelial Cell Line ◽  
Endothelin 1 ◽  
Microvascular Endothelial

In this study, we investigated the production of endothelin 1 (ET-1) by a human microvascular endothelial cell line, HMEC-1, co-cultured with Plasmodium falciparum-parasitized red blood cells (pRBCs). The results indicate that hypoxia increased the basal level of ET-1 production by HMEC-1 cells after 24 or 48h of treatment. However, the co-incubation of HMEC-1 cells with pRBCs, but not with uninfected RBCs, induced a dose-dependent decrease of both constitutive and hypoxia-induced ET-1 production. The inhibition was not due to a decrease in cell viability, as lactate dehydrogenase release remained constant. These results indicate that pRBCs are able to interfere with both the constitutive and stimulated ET-1 release from the microvascular endothelium, thus inducing local modifications of the vascular tone and of the inflammatory response. This could be of relevance in the pathogenesis of the most severe forms of P. falciparum infections, such as cerebral malaria or malaria during pregnancy.

Seeding of Vascular Grafts with an Immortalized Human Dermal Microvascular Endothelial Cell Line

Angiology ◽  
1995 ◽  
Vol 46 (2) ◽  
pp. 107-113 ◽  
Author(s):  
Keith A. Robinson ◽  
Francisco J. Candal ◽  
Neal A. Scott ◽  
Edwin W. Ades
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Vascular Grafts ◽  
Microvascular Endothelial Cell ◽  
Endothelial Cell Line ◽  
Microvascular Endothelial

The development of a human lung microvascular endothelial cell line

1997 ◽  
Vol 56 ◽  
pp. 183
Author(s):  
A.E.M. Zuurbier ◽  
F.P.J. Mul ◽  
H.W.M. Niessen ◽  
A. Kummer ◽  
E.F. Knol ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Line ◽  
Human Lung ◽  
Microvascular Endothelial Cell ◽  
Endothelial Cell Line ◽  
Microvascular Endothelial ◽  
Lung Microvascular Endothelial Cell
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