Optimal cutoff values of primary tumour size to better predict long‐term outcomes in patients with papillary thyroid carcinoma undergoing total thyroidectomy: A preliminary study using restricted cubic spline analysis

2021 ◽  
Author(s):  
Sung Woo Jang ◽  
Jae Hyun Park ◽  
Hyeong Ju Kwon ◽  
Jong Ho Yoon
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Tumour Size ◽  
Primary Tumour ◽  
Papillary Thyroid ◽  
Long Term Outcomes ◽  
Optimal Cutoff ◽  
Preliminary Study

scholarly journals Long-term outcomes of follicular variant vs classic papillary thyroid carcinoma

2018 ◽  
Vol 7 (12) ◽  
pp. 1226-1235 ◽  
Author(s):  
Lauren E Henke ◽  
John D Pfeifer ◽  
Thomas J Baranski ◽  
Todd DeWees ◽  
Perry W Grigsby
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Primary Study ◽  
Papillary Thyroid ◽  
Long Term Outcomes ◽  
Follicular Variant ◽  
Kaplan Meier ◽  
Mutational Status ◽  
Clinicopathologic Factors

The majority of papillary thyroid carcinoma (PTC) cases comprise classic papillary (C-PTC) and follicular variant (FV-PTC) histologic sub-types. Historically, clinical equivalency was assumed, but recent data suggest C-PTC may have poorer outcomes. However, large single-institution series with long-term outcomes of C-PTC and FV-PTC, using modern pathologic criteria for FV-PTC, are needed. Our objective was to compare prevalence and impact of clinicopathologic factors, including BRAF mutation status, on long-term outcomes of C-PTC and FV-PTC. We hypothesized that patients with C-PTC would have higher risk disease features and worse survival outcomes. This retrospective study included 1293 patients treated at a single, US academic institution between 1943 and 2009 with mean follow-up of 8.6 years. All patients underwent either partial or total thyroidectomy and had invasive C-PTC or FV-PTC per modern pathology criteria. Primary study measurements included differences in recurrence-free survival (RFS), disease-specific survival (DSS) and associations with clinicopathologic factors including the BRAF mutation. Compared to FV-PTC, C-PTC was associated with multiple features of high-risk disease (P < 0.05) and significantly reduced RFS and DSS. Survival differences were consistent across univariate, multivariate and Kaplan–Meier analyses. BRAF mutations were more common in C-PTC (P = 0.002). However, on Kaplan–Meier analysis, mutational status did not significantly impact RFS or DSS for patients with either histologic sub-type. C-PTC therefore indicates higher-risk disease and predicts for significantly poorer long-term outcomes when compared to FV-PTC. The nature of this difference in outcome is not explained by traditional histopathologic findings or by the BRAF mutation.

Long-term outcomes of central neck dissection for cN0 papillary thyroid carcinoma

2017 ◽  
Vol 38 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Davide Giordano ◽  
Andrea Frasoldati ◽  
Enrico Gabrielli ◽  
Carmine Pernice ◽  
Michele Zini ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Neck Dissection ◽  
Central Neck Dissection ◽  
Central Neck ◽  
Papillary Thyroid ◽  
Long Term Outcomes

scholarly journals Papillary Thyroid Carcinoma as a Lateral Neck Cyst: A Cystic Metastatic Node versus an Ectopic Thyroid Tissue

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Frhana Rahmat ◽  
Ananth Kumar Marutha Muthu ◽  
Navarasi S Raja Gopal ◽  
Soh Jo Han ◽  
Azura Sharena Yahaya
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Total Thyroidectomy ◽  
Primary Tumour ◽  
Thyroid Tissue ◽  
Ectopic Thyroid ◽  
Lateral Neck ◽  
Papillary Thyroid ◽  
Histopathological Results

Papillary thyroid carcinoma is the most common thyroid malignancy and frequently metastasizes to regional lymph nodes. Occasionally, metastatic lymph nodes are palpable without the evidence of primary tumour. Papillary thyroid carcinoma of lateral neck cyst is a rare condition. It may arise from thyroid primary which underwent cystic degeneration or true malignant transformation of ectopic thyroid tissue. Herein, we reported two cases with preoperative diagnosis of benign lateral neck cyst but postoperative histopathological results showed primary papillary thyroid carcinoma. Ultrasonography and computed tomography of the neck in both cases showed no significant thyroid lesion. However, the patient in Case  2 was subjected for total thyroidectomy and histopathological results showed the origin of primary tumour. In conclusion, thorough investigations including total thyroidectomy are indicated in cases of papillary thyroid carcinoma of lateral neck cyst. This practice is to ensure that this type of thyroid cancer can be detected earlier because it has a very good prognosis if treated earlier.

Primary tumour characteristics predict the invasiveness of lymph node metastases in papillary thyroid carcinoma patients

2015 ◽  
Vol 130 (3) ◽  
pp. 302-308 ◽  
Author(s):  
H S Lee ◽  
C Park ◽  
S W Kim ◽  
J W Song ◽  
B K Chun ◽  
...  
Keyword(s):  
Lymph Node ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Node Metastases ◽  
Tumour Size ◽  
Primary Tumour ◽  
Hazard Ratio ◽  
Papillary Thyroid ◽  
Node Metastases ◽  
Male Sex

AbstractObjective:This study evaluated whether primary tumour characteristics are associated with specific features of metastatic lymph nodes in papillary thyroid carcinoma patients.Method:A retrospective review of 411 patients with pathologically diagnosed cervical lymph node metastasis was conducted.Results:A metastatic lymph node focus size of at least 2 mm was independently associated with a primary tumour size of at least 1 cm (hazard ratio 1.962) and with male sex (hazard ratio 1.947). A number of at least five lymph node metastases was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.863), extrathyroidal extension (hazard ratio 1.737) and male sex (hazard ratio 1.689). Extranodal extension was independently associated with a primary tumour size of at least 1 cm (hazard ratio 2.288), extrathyroidal extension (2.201) and male sex (hazard ratio 1.733).Conclusion:Primary papillary thyroid carcinoma characteristics are related to the pathological features of lymph node metastases.

Long-term outcomes of observation for clinically negative central compartment lymph nodes in papillary thyroid carcinoma

2014 ◽  
Vol 272 (12) ◽  
pp. 3801-3804 ◽  
Author(s):  
Jie Liu ◽  
Zhengang Xu ◽  
Zhengjiang Li ◽  
Zongmin Zhang ◽  
Pingzhang Tang ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Central Compartment ◽  
Papillary Thyroid ◽  
Long Term Outcomes

scholarly journals Predictors of thyroglobulin in the lymph nodes recurrence of papillary thyroid carcinoma undergoing total thyroidectomy

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhichao Xing ◽  
Yuxuan Qiu ◽  
Zhe Li ◽  
Lingyun Zhang ◽  
Yuan Fei ◽  
...  
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Total Thyroidectomy ◽  
Radioactive Iodine ◽  
Independent Predictor ◽  
Central Neck Dissection ◽  
American Thyroid Association ◽  
Papillary Thyroid ◽  
Serum Thyroglobulin

Abstract Background To investigate the association between postoperative lymph nodes (LNs) recurrence and distinct serum thyroglobulin (Tg) levels in patients with papillary thyroid carcinoma (PTC). Methods This study included PTC patients who underwent total thyroidectomy (TT) with at least central neck dissection and then re-operated due to recurrence of LNs between January 2013 and June 2018. These patients were grouped by negative or positive serum Tg levels according to the American Thyroid Association guidelines. Results Of the 60 included patients, 49 underwent radioactive iodine (RAI) treatment. Maximum unstimulated Tg (uTg) ≥ 0.2 ng/mL were associated with larger diameter of recurrent LNs (P = 0.027), and higher rate of metastatic LNs (P < 0.001). Serum-stimulated Tg (off-Tg) ≥ 1 ng/mL (P = 0.047) and unstimulated Tg (on-Tg) ≥ 0.2 ng/Ml (P = 0.013) were associated with larger diameter of recurrent LNs. Number of metastatic LNs ≥ 8 was an independent predictor for postoperative maximum uTg ≥ 0.2 ng/mL (OR = 8.767; 95% CI = 1.392–55.216; P = 0.021). Ratio of metastatic LNs ≥ 25% was an independent predictor for off-Tg ≥ 1 ng/mL (OR = 20.997; 95% CI = 1.649–267.384; P = 0.019). Conclusion Postoperative Tg-positive status was associated with larger size of recurrent LNs. Number of metastatic LNs ≥ 8 and ratio of metastatic LNs ≥ 25% were independent predicators for uTg-positive and off-Tg-positive status, respectively.

scholarly journals Long-term survival in a patient with brain metastases of papillary thyroid carcinoma

2016 ◽  
pp. bcr2015213824
Author(s):  
Daniela Guelho ◽  
Cristina Ribeiro ◽  
Miguel Melo ◽  
Francisco Carrilho
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Brain Metastases ◽  
Papillary Thyroid ◽  
Term Survival ◽  
Long Term Survival

P-204 Case report of cutaneous papillary thyroid carcinoma 16 years post total thyroidectomy for benign goiter

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 4-5
Author(s):  
Kefalogianni Thiresia ◽  
Klonaris Dionysios ◽  
Oikonomou Dimitris ◽  
Psomadaki Lydia ◽  
Mastorakis Georgios ◽  
...  
Keyword(s):  
Case Report ◽  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Papillary Thyroid ◽  
Benign Goiter
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