scholarly journals Antithyroid drug therapy in pregnancy and risk of congenital anomalies: Systematic review and meta‐analysis

2021 ◽  
Author(s):  
Medha Agrawal ◽  
Steffan Lewis ◽  
Lakdasa Premawardhana ◽  
Colin M. Dayan ◽  
Peter N. Taylor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Therapy ◽  
Congenital Anomalies ◽  
Meta Analysis ◽  
Antithyroid Drug ◽  
Antithyroid Drug Therapy ◽  
In Pregnancy

Successful Treatment of Graves Disease in Pregnancy with Lugol's Iodine

2000 ◽  
Vol 45 (1) ◽  
pp. 20-21 ◽  
Author(s):  
A. Jamieson ◽  
C.G. Semple
Keyword(s):  
Drug Therapy ◽  
Successful Treatment ◽  
Surgical Intervention ◽  
Antithyroid Drug ◽  
Primary Treatment ◽  
Graves Disease ◽  
Lugol’S Iodine ◽  
Organic Iodine ◽  
Antithyroid Drug Therapy ◽  
In Pregnancy

We report a case of Grave's disease in pregnancy complicated by intolerance of standard antithyroid drug therapy. We describe the success of prolonged use of organic iodine as a primary treatment prior to surgical intervention.

The impact of thyroid function in women at the reproductive age: infertility, pregnancy and the postpartum period

2013 ◽  
Vol 154 (51) ◽  
pp. 2017-2023 ◽  
Author(s):  
Gábor Speer
Keyword(s):  
Clinical Practice ◽  
Drug Therapy ◽  
Practice Guidelines ◽  
Thyroid Dysfunction ◽  
Antithyroid Drug ◽  
Reproductive Age ◽  
Antithyroid Drug Therapy ◽  
Pregnancy And Postpartum ◽  
The Impact ◽  
In Pregnancy

This article reviews the management and diagnosis of thyroid dysfunction during pregnancy and postpartum, which was published by any of the endocrine societies in 2012. The author presents human data based on these clinical practice guidelines, however, there are also many unresolved questions. Especially, there are inconsistencies about screening using plasma TSH measurement. In pregnancy the main causes of hyperthyroidism are Graves’s disease and gestational transient thyrotoxicosis. Generally, gestational transient thyrotoxicosis does not require medication, whereas Graves’s disease needs antithyroid drug therapy. Postpartum thyroiditis occurs more frequently in antithyroid peroxidase-positive women, who should be screened using serum thyrotropin measurements at 6 to 12 gestation weeks and at 3 and 6 months postpartum. Because overt maternal hypothyroidism, due to autoimmune pathophysioloical mechanisms, negatively affects the fetus, timely recognition and treatment are important. The subclinical form of maternal hypothyroidism should also be treated. A link between thyroid dysfunction and infertility has been warranted. Orv. Hetil., 2013, 154(51), 2017–2023.

scholarly journals Management of Graves' hyperthyroidism in pregnancy: focus on both maternal and foetal thyroid function, and caution against surgical thyroidectomy in pregnancy

2009 ◽  
Vol 160 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Peter Laurberg ◽  
Claire Bournaud ◽  
Jesper Karmisholt ◽  
Jacques Orgiazzi
Keyword(s):  
Drug Therapy ◽  
Thyroid Function ◽  
Antithyroid Drug ◽  
Autoimmune Disorder ◽  
Antithyroid Drugs ◽  
Graves Disease ◽  
Limited Effect ◽  
Antithyroid Drug Therapy ◽  
Maternal Thyroid ◽  
In Pregnancy

Graves' disease is a common autoimmune disorder in women in fertile ages. The hyperthyroidism is causedby generation of TSH-receptor activating antibodies. In pregnancy both the antibodies and the antithyroid medication given to the mother pass the placenta and affect the foetal thyroid gland. Thyroid function should be controlled not only in the mother with Graves' hyperthyroidism but also in her foetus.The review includes two cases illustrating some of the problems in managing Graves' disease in pregnancy.Major threats to optimal foetal thyroid function are inadequate or over aggressive antithyroid drug therapy of the mother. It should be taken into account that antithyroid drugs tend to block the foetal thyroid function more effectively than the maternal thyroid function, and that levothyroxin (l-T4) given to the mother will have only a limited effect in the foetus.Surgical thyroidectomy of patients with Graves' hyperthyroidism does not lead to immediate remission of the autoimmune abnormality, and the combination thyroidectomy+withdrawal of antithyroid medication+l-T4 replacement of the mother involves a high risk of foetal hyperthyroidism.ConclusionAntithyroid drug therapy of pregnant women with Graves' hyperthyroidism should be balanced to control both maternal and foetal thyroid function. Surgical thyroidectomy of a pregnant woman with active disease may lead to isolated foetal hyperthyroidism.

A second course of antithyroid drug therapy is effective in patients with relapsed Graves' disease

2018 ◽  
Author(s):  
Khyatisha Seejore ◽  
Fozia Nawaz ◽  
Katherine Kelleher ◽  
Julie Kyaw-Tun ◽  
Julie Lynch ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Antithyroid Drug ◽  
Graves Disease ◽  
Antithyroid Drug Therapy
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