Obesity‐related genetic polymorphisms are associated with the risk of early puberty in Han Chinese girls

2021 ◽  
Author(s):  
Di Li ◽  
Boxian Zhang ◽  
Jinquan Cheng ◽  
Dingyan Chen ◽  
Yu Wu ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Han Chinese ◽  
Early Puberty ◽  
Chinese Girls

scholarly journals Distributive characteristics of the CYP2C9 and AGTR1 genetic polymorphisms in Han Chinese hypertensive patients: a retrospective study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Keping Chen ◽  
Peng Xiao ◽  
Guochun Li ◽  
Chunling Wang ◽  
Chuankun Yang
Keyword(s):  
Genetic Polymorphisms ◽  
Venous Blood ◽  
Gene Chip ◽  
Han Chinese ◽  
Genotype Frequency ◽  
Wild Type ◽  
Angiotensin Ii Receptor ◽  
Hypertensive Patients ◽  
Genotype Frequencies ◽  
Combined Genotypes

Abstract Background There is an individual variation in response to antihypertensive effect of the angiotensin II receptor antagonist. This study aimed to determine the allele and genotype frequencies of CYP2C9 and AGTR1 genetic polymorphisms and explore the potential role of these polymorphisms in guiding the selection of angiotensinIIreceptor antagonist in Han Chinese hypertensive patients. Methods Totally 2419 Han Chinese hypertensive patients and 126 normotensive controls were recruited in this study. Venous blood samples were collected from each patient, and the genetic polymorphisms of CYP2C9 and AGTR1 were assessed using a gene chip platform. The allele and genotype frequency of each gene and the combined genotypes in this study were analyzed respectively. Results The gene chip analysis identified an allelic frequency of 96.51% for CYP2C9*1 and 3.49% for CYP2C9*3 in the cohort of Han Chinese hypertensive patients. Statistical analysis showed that the frequency of wild-type homozygous for CYP2C9*1/*1 was 93.30%, while the frequency of heterozygous for *1/*3 or mutant homozygous for *3/*3 was 6.41% or 0.29%. Meanwhile, we detected allelic frequencies of 95.06% and 4.94% for the A and C allele of AGTR1, respectively. While the genotype frequency of wild-type homozygous for AA was 90.41%, the frequency of heterozygous for AC or mutant homozygous for CC was 9.30% or 0.29%. Notably, we observed that 84.66% (2048/2419) of the subjects exhibited a combined genotype of CYP2C9 and AGTR1 as *1/*1 + AA, while the combined genotypes *3/*3 + AC or *3/*3 + CC were not detected in hypertension patients. Besides, no significant association was found between normotensive controls and hypertensive patients, or among the three grades of hypertensive patients. Conclusions These data revealed the polymorphisms characteristics of CYP2C9 and AGTR1 in Han Chinese hypertensive patients, providing valuable information for genotype-based antihypertension therapy in prospective clinical studies in the future.

scholarly journals Influence of 144 candidate genetic polymorphisms on statin treatment in Han Chinese

Heart ◽  
2011 ◽  
Vol 97 (Suppl 3) ◽  
pp. A69-A70 ◽  
Author(s):  
Y. Qi ◽  
J. Liu ◽  
C.-s. Ma ◽  
X.-h. Liu ◽  
Q. Lv ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Statin Treatment ◽  
Han Chinese

No association between genetic polymorphisms of the NDUFS7 gene and schizophrenia in Han Chinese

2013 ◽  
Vol 23 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Liang Ma ◽  
Wen Zhang ◽  
Jinsong Tang ◽  
Liwen Tan ◽  
Yong-Gang Yao ◽  
...  
Keyword(s):  
Genetic Polymorphisms ◽  
Han Chinese

Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese

2006 ◽  
Vol 29 (1) ◽  
pp. 14-21 ◽  
Author(s):  
Su Guan ◽  
Min Huang ◽  
Eli Chan ◽  
Xiao Chen ◽  
Wei Duan ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Genetic Polymorphisms ◽  
Han Chinese ◽  
Cytochrome P450 2B6

Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population

2012 ◽  
Vol 19 (12) ◽  
pp. 1641-1645 ◽  
Author(s):  
Mei Yuan ◽  
Xiaohui Wang ◽  
Qiong Zhan ◽  
Xiaomei Duan ◽  
Qidong Yang ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

Association of ACYP2 and TSPYL6 Genetic Polymorphisms with Risk of Ischemic Stroke in Han Chinese Population

2016 ◽  
Vol 54 (8) ◽  
pp. 5988-5995 ◽  
Author(s):  
Yiqian Liang ◽  
Rui Zhang ◽  
Shuo Zhang ◽  
Guofa Ji ◽  
Puyu Shi ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

scholarly journals Relationship between genetic polymorphisms in the DRD5 gene and paranoid schizophrenia in northern Han Chinese

2014 ◽  
Vol 13 (1) ◽  
pp. 1609-1618 ◽  
Author(s):  
Y. Zhao ◽  
M. Ding ◽  
H. Pang ◽  
X.M. Xu ◽  
B.J. Wang
Keyword(s):  
Genetic Polymorphisms ◽  
Paranoid Schizophrenia ◽  
Han Chinese

scholarly journals Association of genetic polymorphisms in IL-1R1 and IL-1R2 genes with IgA nephropathy in the Han Chinese population

Oncotarget ◽  
2017 ◽  
Vol 8 (31) ◽  
pp. 50673-50679 ◽  
Author(s):  
Maowei Xie ◽  
Daofa Zhang ◽  
Yin Zhang ◽  
Xiaohong Yang ◽  
Yan Su ◽  
...  
Keyword(s):  
Iga Nephropathy ◽  
Genetic Polymorphisms ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population
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