Different clinicopathologic features predispose to different patterns of distant metastasis with heterogeneous short‐term prognosis in patients with differentiated thyroid cancer

2021 ◽  
Author(s):  
Li‐Cheng Tan ◽  
Nai‐Si Huang ◽  
Peng‐Cheng Yu ◽  
Pei‐Zhen Han ◽  
Wan‐Lin Liu ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Distant Metastasis ◽  
Differentiated Thyroid Cancer ◽  
Clinicopathologic Features ◽  
Short Term

Management of Distant Metastasis in Differentiated Thyroid Cancer

2018 ◽  
pp. 121-140
Author(s):  
David A. Pattison ◽  
Julie A. Miller ◽  
Bhadrakant Khavar ◽  
Jeanne Tie
Keyword(s):  
Thyroid Cancer ◽  
Distant Metastasis ◽  
Differentiated Thyroid Cancer

Short-Term Outcomes after Unilateral versus Complete Thyroidectomy for Malignancy: A National Perspective

2009 ◽  
Vol 75 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Marc Zerey ◽  
Ajita S. Prabhu ◽  
William L. Newcomb ◽  
Amy E. Lincourt ◽  
Kent W. Kercher ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Length Of Stay ◽  
Differentiated Thyroid Cancer ◽  
Operative Management ◽  
National Inpatient Sample ◽  
Short Term ◽  
Thyroid Lobectomy ◽  
Well Differentiated ◽  
National Perspective ◽  
Total Charges

The extent of thyroidectomy for well-differentiated thyroid cancer (WDTC) remains controversial. We compared outcomes of patients undergoing unilateral thyroid lobectomy (UTL) versus complete thyroidectomy (CT) to determine the best operative management of WDTC. We compared outcomes of patients who underwent UTL or CT for malignancy using the 1999 to 2003 editions of the National Inpatient Sample database. A total of 13,854 patients underwent UTL (n = 4,238) and CT (n = 9,616). The CT group was more likely to have complications than the UTL group (15% vs 6%, P < 0.0001). Mean total charges were higher in the CT group ($11,432) versus the UTL group ($9,739), as was LOS (2 days versus 1 day); P < 0.0001. Complete thyroidectomy is associated with increased morbidity, total charges, and length of stay. The higher risk of short-term complications should be considered when considering performing a complete thyroidectomy for WDTC.

scholarly journals Clinical management and outcome of papillary and follicular (differentiated) thyroid cancer presenting with distant metastasis at diagnosis

Cancer ◽  
2007 ◽  
Vol 110 (7) ◽  
pp. 1451-1456 ◽  
Author(s):  
Elliot Sampson ◽  
James D. Brierley ◽  
Lisa W. Le ◽  
Lorne Rotstein ◽  
Richard W. Tsang
Keyword(s):  
Thyroid Cancer ◽  
Distant Metastasis ◽  
Clinical Management ◽  
Differentiated Thyroid Cancer

scholarly journals Impact of body mass index on short-term outcomes after differentiated thyroid cancer surgery: a nationwide inpatient database study in Japan

2022 ◽  
Vol 11 (1) ◽  
Author(s):  
Takaaki Konishi ◽  
Michimasa Fujiogi ◽  
Nobuaki Michihata ◽  
Takayoshi Niwa ◽  
Kojiro Morita ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Thyroid Cancer ◽  
Length Of Stay ◽  
Differentiated Thyroid Cancer ◽  
Cancer Surgery ◽  
Obese Patients ◽  
Regression Analyses ◽  
Short Term ◽  
Local Complications ◽  
Inpatient Database

Introduction Recent studies have shown worse post-operative outcomes following several surgeries in underweight or obese patients. However, the association between body mass index (BMI) and short-term outcomes following thyroid cancer surgery remains unclear because of the small number of patients, deficits in background data known as risk factors (e.g. cancer stage, operative procedure, intraoperative device use and hospital volume) and categorisation of BMI. Methods We identified patients who underwent thyroidectomy for differentiated thyroid cancer from July 2010 to March 2017 using a Japanese nationwide inpatient database. We used restricted cubic spline (RCS) analyses to investigate potential non-linear associations between BMI (without categorisation) and outcomes: post-operative complications (local and general), duration of anaesthesia, post-operative length of hospital stay and hospitalisation costs. The analyses were adjusted for demographic and clinical backgrounds including the above-stated factors. We also performed multivariable regression analyses for the outcomes with categorisation of BMI. Results Among 59,671 eligible patients, the median BMI was 22.9 kg/m2 (interquartile range (IQR), 20.7–25.6 kg/m2). In total, 3860 patients (6.5%) had local complications and 787 patients (1.3%) had general complications. Although there were no significant associations with local complications, such as bleeding, recurrent laryngeal nerve paralysis and surgical site infection, the occurrence of general complications was significantly associated with higher BMI. BMI showed a linear association with the duration of anaesthesia and U-shaped associations with post-operative length of stay and hospitalisation costs. The lowest points of the U-shaped curves occurred at a BMI of approximately 24 kg/m2. The multivariate regression analyses showed consistent results with the RCS analyses. Discussion/conclusion Whereas RCS analyses revealed no significant associations between BMI and post-operative local complications, obesity was significantly associated with the occurrence of general complications. The linear association between BMI and duration of anaesthesia corresponds to previous studies. Although post-operative length of stay and total hospitalisation costs demonstrated U-shaped associations, the slight differences would not be clinically important. Even if surgeons must pay attention to general complications in obese patients undergoing thyroid cancer surgery as well as other surgeries, underweight and overweight patients can undergo thyroidectomy as safely as patients with normal BMI.

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