Starting age of oestrogen‐progestin therapy is negatively associated with bone mineral density in young adults with Turner syndrome independent of age and body mass index

2021 ◽  
Author(s):  
Satsuki Nishigaki ◽  
Tomoyo Itonaga ◽  
Yukihiro Hasegawa ◽  
Masanobu Kawai
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Young Adults ◽  
Turner Syndrome ◽  
Body Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Negatively Associated ◽  
Progestin Therapy

scholarly journals Blood lead and cadmium levels are negatively associated with bone mineral density in young female adults

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jianfeng Lu ◽  
Ji Lan ◽  
Xiao’e Li ◽  
Zhongxin Zhu
Keyword(s):  
Bone Mineral Density ◽  
Young Adults ◽  
Bone Mineral ◽  
Subgroup Analysis ◽  
Blood Lead ◽  
Negative Association ◽  
Skewed Distribution ◽  
Mineral Density ◽  
Negatively Associated ◽  
Lead And Cadmium

Abstract Background The organ toxicities of lead and cadmium have been extensively studied; however, studies of their toxic effects on bone remain limited, especially in young adults. The objective of this study was to examine the associations of blood lead levels (BLL) and blood cadmium levels (BCL) with bone mineral density (BMD) among young adults. Methods We performed a cross-sectional study using the National Health and Nutrition Examination Survey 2011–2018 database. Because of the skewed distribution, BLL and BCL were Ln-transformed for analysis. Weighted multivariate regressions were performed to evaluate the associations between LnBLL and LnBCL and lumbar BMD. Subgroup analyses were further performed. Results A total of 3234 participants aged 20–35 years were included in this study. No significant association between LnBLL and lumbar BMD was found (β = − 5.6, 95%CI: − 13.5–2.3). However, in the subgroup analysis stratified by sex, this association became negative in women (β = − 18.2, 95%CI: − 29.9– − 6.4). Moreover, this negative association was more prominent in female blacks (β = − 35.5, 95%CI: − 63.4– − 7.6). On the other hand, a negative association between LnBCL and lumbar BMD was found (β = − 7.4, 95%CI: − 14.0– − 0.8). In the subgroup analysis stratified by sex, this negative association only existed in women (β = − 18.7, 95%CI: − 28.0– − 9.5). Moreover, this negative association was more prominent in female whites (β = − 31.1, 95%CI: − 46.2– − 16.1). Conclusions Our finding showed that both BLL and BCL were independently and negatively associated with lumbar BMD among young females, but not among young males.

Effect Of Body Mass Index On Bone Mineral Density Is Age-specific

2021 ◽  
Author(s):  
Lavanya Cherukuri ◽  
April Kinninger ◽  
Divya Birudaraju ◽  
Suvasini Lakshmanan ◽  
Dong Li ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Mineral Density

Decreased Bone Density in Adolescent Girls With Anorexia Nervosa

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 440-447 ◽  
Author(s):  
Laura K. Bachrach ◽  
David Guido ◽  
Debra Katzman ◽  
Iris F. Litt ◽  
Robert Marcus
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Anorexia Nervosa ◽  
Bone Density ◽  
Bone Mass ◽  
Body Mass ◽  
Bone Mineral ◽  
Whole Body ◽  
Mineral Density ◽  
Control Subjects

Osteoporosis develops in women with chronic anorexia nervosa. To determine whether bone mass is reduced in younger patients as well, bone density was studied in a group of adolescent patients with anorexia nervosa. With single- and dual-photon absorptiometry, a comparison was made of bone mineral density of midradius, lumbar spine, and whole body in 18 girls (12 to 20 years of age) with anorexia nervosa and 25 healthy control subjects of comparable age. Patients had significantly lower lumbar vertebral bone density than did control subjects (0.830 ± 0.140 vs 1.054 ± 0.139 g/cm2) and significantly lower whole body bone mass (0.700 ± 0.130 vs 0.955 ± 0.130 g/cm2). Midradius bone density was not significantly reduced. Of 18 patients, 12 had bone density greater than 2 standard deviations less than normal values for age. The diagnosis of anorexia nervosa had been made less than 1 year earlier for half of these girls. Body mass index correlated significantly with bone mass in girls who were not anorexic (P < .05, .005, and .0001 for lumbar, radius, and whole body, respectively). Bone mineral correlated significantly with body mass index in patients with anorexia nervosa as well. In addition, age at onset and duration of anorexia nervosa, but not calcium intake, activity level, or duration of amenorrhea correlated significantly with bone mineral density. It was concluded that important deficits of bone mass occur as a frequent and often early complication of anorexia nervosa in adolescence. Whole body is considerably more sensitive than midradius bone density as a measure of cortical bone loss in this illness. Low body mass index is an important predictor of this reduction in bone mass.

scholarly journals Clinical and subclinical cardiovascular disease in female SLE patients: Interplay between body mass index and bone mineral density

2019 ◽  
Vol 29 (2) ◽  
pp. 135-143 ◽  
Author(s):  
J. Rodríguez-Carrio ◽  
A. Martínez-Zapico ◽  
I. Cabezas-Rodríguez ◽  
L. Benavente ◽  
Á.I. Pérez-Álvarez ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cardiovascular Disease ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Mineral Density ◽  
Subclinical Cardiovascular Disease

scholarly journals Relationship between Bone Mineral Density and Maturity Index in Cervical Smears, Serum Estradiol Levels and Body Mass Index

2013 ◽  
Vol 5 (6) ◽  
Author(s):  
Homayoun Sheikholeslami ◽  
Majid Sotodeh ◽  
Amir Javadi ◽  
Neda Nasirian ◽  
Amir Mohammad Kazemifar ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Body Mass ◽  
Bone Mineral ◽  
Maturity Index ◽  
Serum Estradiol ◽  
Mineral Density ◽  
Cervical Smears ◽  
Estradiol Levels

scholarly journals Relationship between Body Mass Index and T-Scores of Bone Mineral Density in the Hip and Spine Regions among Older Adults with Diabetes: A Retrospective Review

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Abdulaziz F. Hariri ◽  
Mohammad N. Almatrafi ◽  
Aws B. Zamka ◽  
Abdullah S. Babaker ◽  
Tariq M. Fallatah ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Body Mass Index ◽  
Femoral Neck ◽  
Body Mass ◽  
Bone Mineral ◽  
University Hospital ◽  
Lumbar Region ◽  
Mineral Density ◽  
Patients With Diabetes ◽  
Low Bmi

Diabetes mellitus (DM) cases are increasing worldwide, especially in Saudi Arabia. Previous studies suggested a positive relationship between body mass index (BMI) and bone mineral density (BMD) levels. Generally, patients with low BMI (<18.5 kg/m2) have reduced BMD levels and, thus, low T-scores; hence, they are categorized as osteopenic or osteoporotic. In this study, we aimed to determine whether a relationship between BMI and BMD T-scores in the hip and spine regions of patients with diabetes exists. This retrospective record review investigated older adult patients with diabetes in King Abdulaziz University Hospital (n=198; age 50–90 years) who underwent BMD scan between January 1, 2016, and June 25, 2018, regardless of their sex but limited to type 2 DM. The height and weight of all subjects were recorded, and BMI was calculated and categorized. We used SPSS version 21 for data analysis; measures of central tendencies, Pearson’s correlations, chi-square tests, and independent t-tests were employed. We found positive relationships between BMI and BMD T-scores in the hip and spine regions (right femoral neck: R=+0.214, P≤0.002; total right hip: R=+0.912, P≤0.001; left femoral neck: R=+0.939, P≤0.001; total left hip: R=+0.885, P≤0.001; and total lumbar region: R=+0.607, P≤0.001). Low BMI (<18.5 kg/m2) could be a risk factor for osteoporosis, whereas normal/high BMI could be protective against osteoporosis among adults with diabetes.

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