Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers

2020 ◽  
Author(s):  
Antoine Mairesse ◽  
Loris Wauthier ◽  
Louisiane Courcelles ◽  
Urszula Luyten ◽  
Maria‐Cristina Burlacu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Biological Variation ◽  
Analytical Goals

Biological variation and analytical goals of four thyroid function biomarkers in healthy European volunteers

2020 ◽  
Author(s):  
Mairesse Antoine ◽  
Wauthier Loris ◽  
Courcelles Louisiane ◽  
Luyten Urszula ◽  
Burlacu Maria-Cristina ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Biological Variation ◽  
Analytical Goals

Laboratory evaluation of the Du Pont "Dimension Clinical Chemistry System".

1988 ◽  
Vol 34 (9) ◽  
pp. 1899-1903 ◽  
Author(s):  
D Knight ◽  
R Singer ◽  
J M White ◽  
C G Fraser
Keyword(s):  
High Risk ◽  
State Of The Art ◽  
Clinical Chemistry ◽  
Biological Variation ◽  
Analytical Performance ◽  
Laboratory Evaluation ◽  
Laboratory Staff ◽  
Safety Requirements ◽  
Analytical Goals

Abstract We evaluated the analytical performance of the Du Pont Dimension Clinical Chemistry System to assess its suitability as a replacement for the Du Pont aca III, currently routinely used for analysis of pediatric, high-risk, and emergency specimens. Twenty-six analyses were studied. These generally fulfilled pre-set analytical goals for precision based on biological variation or "state of the art." Significant economies were achieved and we found the Dimension to be reliable, easy to operate, and simple to maintain. It also fulfilled safety requirements for analysis of specimens of high risk to laboratory staff.

Biological Variation of thyroid function biomarkers over 24 hours

2021 ◽  
Author(s):  
Yan Zhang ◽  
Da-Hai He ◽  
Shun-Ning Jiang ◽  
Hua-Li Wang ◽  
Xiao-Hua Xu ◽  
...  
Keyword(s):  
Thyroid Function ◽  
Biological Variation

Determination of the biological variation of S100β and lactate dehydrogenase in disease-free patients with malignant melanoma

2012 ◽  
Vol 50 (5) ◽  
Author(s):  
Jaume Trapé ◽  
Jesús Montesinos ◽  
Josefina Franquesa ◽  
Maria Sala ◽  
Cristina Fígols ◽  
...  
Keyword(s):  
Lactate Dehydrogenase ◽  
Malignant Melanoma ◽  
Tumor Resection ◽  
Disease Recurrence ◽  
Sampling Interval ◽  
Biological Variation ◽  
Analytical Goals ◽  
Analytical Variation

AbstractBiological variation is important for determining analytical goals and for establishing the magnitude of change between two consecutive measurements. The aim of this study was to determine the biological variation for S100β and lactate dehydrogenase in patients diagnosed with malignant melanoma but without evidence of disease recurrence.The biological variation of S100β and lactate dehydrogenase was estimated from a mean of four consecutive measurements in 32 patients diagnosed with malignant melanoma but without evidence of disease recurrence, 3 months after tumor resection or 4 months after finishing adjuvant treatment. The mean sampling interval was 3 months.Mean concentrations of S100β and lactate dehydrogenase were 0.0557 μg/L and 6.3 μkat/L, respectively. Between-run analytical variation was 3.5% at 0.181 μg/L for S100β and 3.5% at 2.83 μkat/L for lactate dehydrogenase. Biological variations obtained for S100β and lactate dehydrogenase were 14.2% and 8.2%, respectively. The analytical goals (defined as 50% of biological variation) were 7.1% for S100β and 4.1% for lactate dehydrogenase.The estimation of biological variation allows us to calculate analytical goals and reference change values. These are necessary tools for the correct interpretation of serial measurements in patient follow-up.

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