Sociodemographic, lifestyle and medical influences on serum testosterone and sex hormone–binding globulin in men from UK Biobank

2020 ◽  
Author(s):  
Bu B. Yeap ◽  
Ross J. Marriott ◽  
Leen Antonio ◽  
Shalender Bhasin ◽  
Adrian S. Dobs ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Uk Biobank ◽  
Hormone Binding

Longitudinal changes in serum testosterone and sex hormone‐binding globulin in men aged 40–69 years from the UK Biobank

2021 ◽  
Author(s):  
Ross J. Marriott ◽  
Kevin Murray ◽  
Graeme J. Hankey ◽  
Laurens Manning ◽  
Girish Dwivedi ◽  
...  
Keyword(s):  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Uk Biobank ◽  
Hormone Binding ◽  
Longitudinal Changes ◽  
The Uk

Salivary Free Testosterone in Hirsutism

1989 ◽  
Vol 26 (6) ◽  
pp. 522-526 ◽  
Author(s):  
Joško Osredkar ◽  
Ivan Vrhovec ◽  
Niko Jesenovec ◽  
Andreja Kocijančič ◽  
Janez Preželj
Keyword(s):  
Serum Testosterone ◽  
Free Testosterone ◽  
Human Saliva ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Dehydroepiandrosterone Sulphate ◽  
Hormone Binding ◽  
Salivary Testosterone ◽  
Diagnostic Use

A sensitive, specific and accurate direct radioimmunoassay of testosterone in human saliva is described. A single salivary testosterone result is shown to be of greater diagnostic use in hirsutism than any of the currently used serum androgen assays. Thus, of 50 hirsute patients, salivary testosterone (Sa-T) was elevated in 34 patients, sex hormone-binding globulin (SHBG) was decreased in 30 women, serum testosterone (S-T) elevated in 13, dehydroepiandrosterone sulphate (DHEA-S) was elevated in 14, and androstenedione in three of the investigated group.

scholarly journals Serum Testosterone is Inversely and Sex Hormone-binding Globulin is Directly Associated with All-cause Mortality in Men

2020 ◽  
Author(s):  
Bu B Yeap ◽  
Ross J Marriott ◽  
Leen Antonio ◽  
Yi X Chan ◽  
Suchitra Raj ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Serum Testosterone ◽  
Cox Proportional Hazards ◽  
Community Dwelling ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Atherosclerotic Cardiovascular Disease ◽  
Hormone Binding ◽  
Baseline Serum ◽  
Related Mortality

Abstract Context Serum testosterone concentrations decline with age, while serum sex hormone-binding globulin (SHBG) concentrations increase. Objective To analyze associations of baseline serum testosterone and SHBG concentrations, and calculated free testosterone (cFT) values, with all-cause and cause-specific mortality in men. Design, Setting, and Participants The UK Biobank prospective cohort study of community-dwelling men aged 40–69 years old, followed for 11 years. Main Outcome Measures All-cause, atherosclerotic cardiovascular disease (CVD) and cancer-related mortality. Cox proportional hazards regression was performed, adjusting for age, waist circumference, medical conditions, and other covariates. Models for testosterone included SHBG and vice versa. Results In a complete case analysis of 149 436 men with 10 053 deaths (1925 CVD and 4927 cancer-related), men with lower testosterone had a higher mortality rate from any cause (lowest vs highest quintile, Q1 vs Q5, fully-adjusted hazard ratio [HR] = 1.14, 95% confidence interval [CI] = 1.06–1.22, overall trend P < 0.001), and cancer (HR = 1.20, CI = 1.09–1.33, P < 0.001), with no association for CVD deaths. Similar results were seen for cFT. Men with lower SHBG had a lower mortality rate from any cause (Q1 vs Q5, HR = 0.68, CI = 0.63–0.73, P < 0.001), CVD (HR = 0.70, CI = 0.59–0.83, P < 0.001), and cancer (HR = 0.80, CI = 0.72–0.89, P < 0.001). A multiply imputed dataset (N = 208 425, 15 914 deaths, 3128 CVD-related and 7468 cancer-related) and analysis excluding deaths within the first 2 years (9261, 1734, and 4534 events) yielded similar results. Conclusions Lower serum testosterone is independently associated with higher all-cause and cancer-related, but not CVD-related, mortality in middle-aged to older men. Lower SHBG is independently associated with lower all-cause, CVD-related, and cancer-related mortality. Confirmation and determination of causality requires mechanistic studies and prospective trials.

scholarly journals Relation between Serum Testosterone, Serum Estradiol, Sex Hormone-Binding Globulin, and Geometrical Measures of Adult Male Proximal Femur Strength

2009 ◽  
Vol 94 (3) ◽  
pp. 853-860 ◽  
Author(s):  
Thomas G. Travison ◽  
Andre B. Araujo ◽  
Thomas J. Beck ◽  
Rachel E. Williams ◽  
Richard V. Clark ◽  
...  
Keyword(s):  
Adult Male ◽  
Proximal Femur ◽  
Serum Testosterone ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Serum Estradiol ◽  
Hormone Binding
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